Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice

Meiotic arrest is a common cause of human male infertility, but the causes of this arrest are poorly understood. Transactive response DNA-binding protein of 43 kDa (TDP-43) is highly expressed in spermatocytes in the preleptotene and pachytene stages of meiosis. TDP-43 is linked to several human neu...

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Veröffentlicht in:	The Journal of biological chemistry 2021-11, Vol.297 (5), p.101231-101231, Article 101231
Hauptverfasser:	Campbell, Kaitlyn M., Xu, Yiding, Patel, Chintan, Rayl, Jeremy M., Zomer, Helena D., Osuru, Hari Prasad, Pratt, Michael, Pramoonjago, Patcharin, Timken, Madeline, Miller, Lyndzi M., Ralph, Abigail, Storey, Kathryn M., Peng, Yiheng, Drnevich, Jenny, Lagier-Tourenne, Clotilde, Wong, Philip C., Qiao, Huanyu, Reddi, Prabhakara P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA-Binding Proteins - deficiency DNA-Binding Proteins - metabolism Female Gene Expression Regulation Infertility, Male - genetics Infertility, Male - metabolism Male male infertility meiosis Meiotic Prophase I Mice Mice, Knockout Seminiferous Epithelium - metabolism Spermatocytes - metabolism Spermatogenesis TAR DNA-binding protein of 43 kDa testis
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