Remodelling of oxygen-transporting tracheoles drives intestinal regeneration and tumorigenesis in Drosophila

The Drosophila trachea, as the functional equivalent of mammalian blood vessels, senses hypoxia and oxygenates the body. Here, we show that the adult intestinal tracheae are dynamic and respond to enteric infection, oxidative agents and tumours with increased terminal branching. Increased tracheatio...

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Veröffentlicht in:	Nature cell biology 2021-05, Vol.23 (5), p.497-510
Hauptverfasser:	Tamamouna, Vasilia, Rahman, M. Mahidur, Petersson, Monika, Charalambous, Irini, Kux, Kristina, Mainor, Hannah, Bolender, Verena, Isbilir, Buse, Edgar, Bruce A., Pitsouli, Chrysoula
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/51 14/19 14/34 14/35 14/63 38/1 38/89 631/136/16 631/532/2437 631/80/304 64 64/24 82 96 96/2 Animals Animals, Genetically Modified - metabolism Biomedical and Life Sciences Blood vessels Branching Cancer Cancer Research Carcinogenesis Cell Biology Cell Transformation, Neoplastic - metabolism Damage Developmental Biology DNA-Binding Proteins - metabolism Drosophila Drosophila - metabolism Drosophila Proteins - metabolism Epithelium Fibroblast growth factor receptors Fruit flies Gene Expression Regulation, Developmental - physiology Genetic aspects Health aspects Hypoxia Hypoxia - metabolism Hypoxia-inducible factor 1a Insects Intestine Intestines Life Sciences Mammals Midgut Oncology, Experimental Oxidative stress Oxygen Oxygen - metabolism Oxygenation Physiological transport Reactive oxygen species Receptors, Fibroblast Growth Factor - genetics Regeneration Regeneration (Biology) Regeneration - physiology Signaling Stem Cells Trachea Tumorigenesis Tumors
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