A Direct C11 Alkylation Strategy on the Saxitoxin Core: A Synthesis of (+)-11-Saxitoxinethanoic Acid

The bis-guanidinium ion family of natural products are revered for their utility in the study of ion channel physiology. While many congeners have been isolated with various oxidation and sulfation patterns, only two members of this family have been isolated bearing a carbon–carbon bond at C11, name...

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Veröffentlicht in:Organic letters 2019-10, Vol.21 (19), p.7999-8002
Hauptverfasser: Paladugu, Srinivas R, James, Chintelle K, Looper, Ryan E
Format: Artikel
Sprache:eng
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