PSMA radioligand therapy for solid tumors other than prostate cancer: background, opportunities, challenges, and first clinical reports

In the past decade, a growing body of literature has reported promising results for prostate-specific membrane antigen (PSMA)-targeted radionuclide imaging and therapy in prostate cancer. First clinical studies evaluating the efficacy of [ 177 Lu]Lu-PSMA radioligand therapy (PSMA-RLT) demonstrated f...

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Veröffentlicht in:European journal of nuclear medicine and molecular imaging 2021-12, Vol.48 (13), p.4350-4368
Hauptverfasser: Uijen, M. J. M., Derks, Y. H. W., Merkx, R. I. J., Schilham, M. G. M., Roosen, J., Privé, B. M., van Lith, S. A. M., van Herpen, C. M. L., Gotthardt, M., Heskamp, S., van Gemert, W. A. M., Nagarajah, J.
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container_issue 13
container_start_page 4350
container_title European journal of nuclear medicine and molecular imaging
container_volume 48
creator Uijen, M. J. M.
Derks, Y. H. W.
Merkx, R. I. J.
Schilham, M. G. M.
Roosen, J.
Privé, B. M.
van Lith, S. A. M.
van Herpen, C. M. L.
Gotthardt, M.
Heskamp, S.
van Gemert, W. A. M.
Nagarajah, J.
description In the past decade, a growing body of literature has reported promising results for prostate-specific membrane antigen (PSMA)-targeted radionuclide imaging and therapy in prostate cancer. First clinical studies evaluating the efficacy of [ 177 Lu]Lu-PSMA radioligand therapy (PSMA-RLT) demonstrated favorable results in prostate cancer patients. [ 177 Lu]Lu-PSMA is generally well tolerated due to its limited side effects. While PSMA is highly overexpressed in prostate cancer cells, varying degrees of PSMA expression have been reported in other malignancies as well, particularly in the tumor-associated neovasculature. Hence, it is anticipated that PSMA-RLT could be explored for other solid cancers. Here, we describe the current knowledge of PSMA expression in other solid cancers and define a perspective towards broader clinical implementation of PSMA-RLT. This review focuses specifically on salivary gland cancer, glioblastoma, thyroid cancer, renal cell carcinoma, hepatocellular carcinoma, lung cancer, and breast cancer. An overview of the (pre)clinical data on PSMA immunohistochemistry and PSMA PET/CT imaging is provided and summarized. Furthermore, the first clinical reports of non-prostate cancer patients treated with PSMA-RLT are described.
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J. M. ; Derks, Y. H. W. ; Merkx, R. I. J. ; Schilham, M. G. M. ; Roosen, J. ; Privé, B. M. ; van Lith, S. A. M. ; van Herpen, C. M. L. ; Gotthardt, M. ; Heskamp, S. ; van Gemert, W. A. M. ; Nagarajah, J.</creator><creatorcontrib>Uijen, M. J. M. ; Derks, Y. H. W. ; Merkx, R. I. J. ; Schilham, M. G. M. ; Roosen, J. ; Privé, B. M. ; van Lith, S. A. M. ; van Herpen, C. M. L. ; Gotthardt, M. ; Heskamp, S. ; van Gemert, W. A. M. ; Nagarajah, J.</creatorcontrib><description>In the past decade, a growing body of literature has reported promising results for prostate-specific membrane antigen (PSMA)-targeted radionuclide imaging and therapy in prostate cancer. First clinical studies evaluating the efficacy of [ 177 Lu]Lu-PSMA radioligand therapy (PSMA-RLT) demonstrated favorable results in prostate cancer patients. [ 177 Lu]Lu-PSMA is generally well tolerated due to its limited side effects. While PSMA is highly overexpressed in prostate cancer cells, varying degrees of PSMA expression have been reported in other malignancies as well, particularly in the tumor-associated neovasculature. Hence, it is anticipated that PSMA-RLT could be explored for other solid cancers. Here, we describe the current knowledge of PSMA expression in other solid cancers and define a perspective towards broader clinical implementation of PSMA-RLT. This review focuses specifically on salivary gland cancer, glioblastoma, thyroid cancer, renal cell carcinoma, hepatocellular carcinoma, lung cancer, and breast cancer. An overview of the (pre)clinical data on PSMA immunohistochemistry and PSMA PET/CT imaging is provided and summarized. 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subjects Antigens
Brain cancer
Breast cancer
Cardiology
Computed tomography
Dipeptides
Glioblastoma
Hepatocellular carcinoma
Heterocyclic Compounds, 1-Ring
Humans
Imaging
Immunohistochemistry
Kidney cancer
Lung cancer
Lung carcinoma
Lutetium isotopes
Male
Medical imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Oncology – General
Oral cancer
Orthopedics
Patients
Positron emission
Positron Emission Tomography Computed Tomography
Prostate cancer
Prostatic Neoplasms - diagnostic imaging
Prostatic Neoplasms - radiotherapy
Prostatic Neoplasms, Castration-Resistant
Radioisotopes
Radiology
Renal cell carcinoma
Review
Review Article
Salivary gland
Salivary glands
Side effects
Solid tumors
Therapy
Thyroid cancer
Tomography
Tumors
title PSMA radioligand therapy for solid tumors other than prostate cancer: background, opportunities, challenges, and first clinical reports
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