Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

Adjuvants are critical for improving the quality and magnitude of adaptive immune responses to vaccination. Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines have shown great efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but the mechanism of act...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2021-12, Vol.54 (12), p.2877-2892.e7
Hauptverfasser:	Alameh, Mohamad-Gabriel, Tombácz, István, Bettini, Emily, Lederer, Katlyn, Ndeupen, Sonia, Sittplangkoon, Chutamath, Wilmore, Joel R., Gaudette, Brian T., Soliman, Ousamah Y., Pine, Matthew, Hicks, Philip, Manzoni, Tomaz B., Knox, James J., Johnson, John L., Laczkó, Dorottya, Muramatsu, Hiromi, Davis, Benjamin, Meng, Wenzhao, Rosenfeld, Aaron M., Strohmeier, Shirin, Lin, Paulo J.C., Mui, Barbara L., Tam, Ying K., Karikó, Katalin, Jacquet, Alain, Krammer, Florian, Bates, Paul, Cancro, Michael P., Weissman, Drew, Luning Prak, Eline T., Allman, David, Igyártó, Botond Z., Locci, Michela, Pardi, Norbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism adjuvant Adjuvants, Immunologic Animals B-Lymphocytes - immunology COVID-19 - immunology COVID-19 Vaccines - immunology Germinal Center - immunology germinal centers HEK293 Cells Humans IL-6 Immunity, Humoral influenza virus Interleukin-6 - genetics Interleukin-6 - metabolism lipid nanoparticle Liposomes - administration & dosage Mice Mice, Inbred BALB C mRNA Vaccines - genetics mRNA Vaccines - immunology Nanoparticles - administration & dosage Protein Subunits - genetics SARS-CoV-2 SARS-CoV-2 - physiology T-Lymphocytes, Helper-Inducer - immunology Tfh cell vaccine
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