Ouabain and chloroquine trigger senolysis of BRAF‐V600E‐induced senescent cells by targeting autophagy

The expression of BRAF‐V600E triggers oncogene‐induced senescence in normal cells and is implicated in the development of several cancers including melanoma. Here, we report that cardioglycosides such as ouabain are potent senolytics in BRAF senescence. Sensitization by ATP1A1 knockdown and protecti...

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Veröffentlicht in:	Aging cell 2021-09, Vol.20 (9), p.e13447-n/a
Hauptverfasser:	L’Hôte, Valentin, Courbeyrette, Régis, Pinna, Guillaume, Cintrat, Jean‐Christophe, Le Pavec, Gwenaëlle, Delaunay‐Moisan, Agnès, Mann, Carl, Thuret, Jean‐Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Aging AKT protein Alzheimer's disease Apoptosis Autophagy Autophagy - drug effects Cardiac glycosides cardioglycosides Cardiotonic agents Cell death cellular senescence Cellular Senescence - drug effects Cellular signal transduction Chemical Sciences Chloroquine Chloroquine - pharmacology DNA damage Dose-Response Relationship, Drug Drug dosages Endoplasmic reticulum endoplasmic reticulum stress Fibroblasts Heart failure Humans Kinases Melanoma Na+/K+-exchanging ATPase Na,K‐ATPase Original Original Papers Ouabain Ouabain - pharmacology Phagocytosis Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Senescence senolytic Signal transduction Src
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