Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile

Aims/hypothesis Higher maternal BMI during pregnancy is associated with higher offspring birthweight, but it is not known whether this is solely the result of adverse metabolic consequences of higher maternal adiposity, such as maternal insulin resistance and fetal exposure to higher glucose levels,...

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Veröffentlicht in:	Diabetologia 2021-12, Vol.64 (12), p.2790-2802
Hauptverfasser:	Thompson, William D., Beaumont, Robin N., Kuang, Alan, Warrington, Nicole M., Ji, Yingjie, Tyrrell, Jessica, Wood, Andrew R., Scholtens, Denise M., Knight, Bridget A., Evans, David M., Lowe, William L., Santorelli, Gillian, Azad, Rafaq, Mason, Dan, Hattersley, Andrew T., Frayling, Timothy M., Yaghootkar, Hanieh, Borges, Maria Carolina, Lawlor, Deborah A., Freathy, Rachel M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adiposity - genetics Birth Weight Body fat Body Mass Index Cord blood Female Fetuses Genetic diversity Genome-Wide Association Study Genomes Genotypes Glucose Human Physiology Humans Infant, Newborn Insulin Insulin resistance Internal Medicine Leptin Maternal & child health Mechanical properties Medicine Medicine & Public Health Metabolic Diseases Metabolism Neonates Pregnancy Prenatal exposure Reproducibility of Results Sensitivity analysis Single-nucleotide polymorphism
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