COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction
ObjectiveThe initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as...
Gespeichert in:
| Veröffentlicht in: | Heart (British Cardiac Society) 2022-03, Vol.108 (6), p.458-466 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 466 |
|---|---|
| container_issue | 6 |
| container_start_page | 458 |
| container_title | Heart (British Cardiac Society) |
| container_volume | 108 |
| creator | Algowhary, Magdy Uguz, Berat Oliveira, Dinaldo C Zimbakov, Zan Cercek, Miha Loh, Poay Huan Calmac, Lucian Roura-Ferrer, Gerard Quadros, Alexandre Scotto di Uccio, Fortunato von Birgelen, Clemens Versaci, Francesco Ten Berg, Jurriën Casella, Gianni Wong, Aaron Sung Lung Kala, Petr Carrillo, Xavier Dirksen, Maurits Theodoor Becerra-Muñoz, Víctor Manuel Kang-yin Lee, Michael Juzar, Dafsah A de Moura Joaquim, Rodrigo Bakraceski, Nikola Zilio, Filippo Kraaijeveld, Adriaan O Galasso, Gennaro Lux, Arpad Marinucci, Lucia Guiducci, Vincenzo Scoccia, Alessandra Ugur Mert, Kadir Flores Rios, Xacobe Kovarnik, Tomas Kidawa, Michal Moreu, Jose Flavien, Vincent Fabris, Enrico Lozano Martìnez-Luengas, Iñigo Boccalatte, Marco Bosa Ojeda, Francisco Arellano-Serrano, Carlos Caiazzo, Gianluca Cirrincione, Giuseppe Kao, Hsien-Li Sanchis Fores, Juan Vignali, Luigi Pereira, Helder Manzo-Silberman, Stéphane Özkan, Alev Arat Scheller, Bruno Lehtola, Heidi Teles, Rui Mantis, Christos Ylitalo, Antti Brum Silveira, Joao Antonio Zoni, Rodrigo Bessonov, Ivan Savonitto, Stefano Kochiadakis, George Alexopoulos, Dimitrios Uribe, Carlos Kanakakis, John Faurie, Benjamin Gabrielli, Gabriele Gutiérrez, Alejandro Bachini, Juan Pablo Tam, Franckie CC Rodriguez, Alfredo Lukito, Antonia Saint-Joy, Veauthyelau Pessah, Gustavo Tuccillo, Bernardino Cortese, Giuliana Parodi, Guido Bouraghda, Mohamed Abed Kedhi, Elvin Lamelas, Pablo Nardin, Matteo Verdoia, Monica Kinnaird, Tim Cottin, Yves Ijsselmuiden, Alexander Royaards, Kees-Jan Siviglia, Massimo Amoroso, Giovanni Banning, Adrian Santucci, Andrea Spedicato, Leonardo Mehilli, Julinda Levesque, Sébastien Ludman, Peter Deharo, Pierre Benit, Edouard Agostoni, Pierfrancesco Camacho-Freiere, Santiago Brouwer, Marc Wilbert, Bor Smits, Pieter Laine, Mike Moreno, Raul |
| description | ObjectiveThe initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days).MethodsThis is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, South-East Asia and North Africa, enrolling 16 674 patients with ST segment elevation myocardial infarction (STEMI) undergoing PPPCI in March/June 2019 and 2020. The main study outcomes were the incidence of PPCI, delayed treatment (ischaemia time >12 hours and door-to-balloon >30 min), in-hospital and 30-day mortality.ResultsIn 2020, during the pandemic, there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio 0.843, 95% CI 0.825 to 0.861, p75 years) (p=0.015), and was not related to the peak of cases or deaths due to COVID-19. The heterogeneity among centres was high (p |
| doi_str_mv | 10.1136/heartjnl-2021-319750 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8561823</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2633130003</sourcerecordid><originalsourceid>FETCH-LOGICAL-b543t-e460ee5499d17691627354a211a791c97c63df8973fe056af7507717e57b7c393</originalsourceid><addsrcrecordid>eNp9kU1v1DAQhiMEoqXwDxCyxIUDoZ74K74gVctXpUo9tCBulteZsF4l9mInlfbf19G2pXDgZGvmmXf8-q2q10A_ADB5ukGbpm0Y6oY2UDPQStAn1TFw2ZYS_Hxa7kyIWlKmjqoXOW8ppVy38nl1xLgCkBKOq251-eP8Uw2a7GzocPTuPRnRbWzwzg4k4Q5TP2cfAyl9wmjd2T0ZY5rs4Kc98YFcXRMc8MZOCzTuo7Op82XWh94mt1RfVs96O2R8dXeeVN-_fL5efasvLr-er84u6rXgbKqRS4oouNYdKKlBNooJbhsAqzQ4rZxkXd9qxXqkQtq-OFYKFAq1Vo5pdlJ9POju5vWIncMwJTuYXfKjTXsTrTd_d4LfmF_xxrRCQtuwIvDuTiDF3zPmyYw-OxwGGzDO2TRCU2jKJl7Qt_-g2zinUOyZRjIGrPz2IsgPlEsx54T9w2OAmiVGcx-jWWI0hxjL2JvHRh6G7nMrAD0A63H7Z_F_NW8Bo9aprA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2633130003</pqid></control><display><type>article</type><title>COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction</title><source>MEDLINE</source><source>PubMed Central</source><creator>Algowhary, Magdy ; Uguz, Berat ; Oliveira, Dinaldo C ; Zimbakov, Zan ; Cercek, Miha ; Loh, Poay Huan ; Calmac, Lucian ; Roura-Ferrer, Gerard ; Quadros, Alexandre ; Scotto di Uccio, Fortunato ; von Birgelen, Clemens ; Versaci, Francesco ; Ten Berg, Jurriën ; Casella, Gianni ; Wong, Aaron Sung Lung ; Kala, Petr ; Carrillo, Xavier ; Dirksen, Maurits Theodoor ; Becerra-Muñoz, Víctor Manuel ; Kang-yin Lee, Michael ; Juzar, Dafsah A ; de Moura Joaquim, Rodrigo ; Bakraceski, Nikola ; Zilio, Filippo ; Kraaijeveld, Adriaan O ; Galasso, Gennaro ; Lux, Arpad ; Marinucci, Lucia ; Guiducci, Vincenzo ; Scoccia, Alessandra ; Ugur Mert, Kadir ; Flores Rios, Xacobe ; Kovarnik, Tomas ; Kidawa, Michal ; Moreu, Jose ; Flavien, Vincent ; Fabris, Enrico ; Lozano Martìnez-Luengas, Iñigo ; Boccalatte, Marco ; Bosa Ojeda, Francisco ; Arellano-Serrano, Carlos ; Caiazzo, Gianluca ; Cirrincione, Giuseppe ; Kao, Hsien-Li ; Sanchis Fores, Juan ; Vignali, Luigi ; Pereira, Helder ; Manzo-Silberman, Stéphane ; Özkan, Alev Arat ; Scheller, Bruno ; Lehtola, Heidi ; Teles, Rui ; Mantis, Christos ; Ylitalo, Antti ; Brum Silveira, Joao Antonio ; Zoni, Rodrigo ; Bessonov, Ivan ; Savonitto, Stefano ; Kochiadakis, George ; Alexopoulos, Dimitrios ; Uribe, Carlos ; Kanakakis, John ; Faurie, Benjamin ; Gabrielli, Gabriele ; Gutiérrez, Alejandro ; Bachini, Juan Pablo ; Tam, Franckie CC ; Rodriguez, Alfredo ; Lukito, Antonia ; Saint-Joy, Veauthyelau ; Pessah, Gustavo ; Tuccillo, Bernardino ; Cortese, Giuliana ; Parodi, Guido ; Bouraghda, Mohamed Abed ; Kedhi, Elvin ; Lamelas, Pablo ; Nardin, Matteo ; Verdoia, Monica ; Kinnaird, Tim ; Cottin, Yves ; Ijsselmuiden, Alexander ; Royaards, Kees-Jan ; Siviglia, Massimo ; Amoroso, Giovanni ; Banning, Adrian ; Santucci, Andrea ; Spedicato, Leonardo ; Mehilli, Julinda ; Levesque, Sébastien ; Ludman, Peter ; Deharo, Pierre ; Benit, Edouard ; Agostoni, Pierfrancesco ; Camacho-Freiere, Santiago ; Brouwer, Marc ; Wilbert, Bor ; Smits, Pieter ; Laine, Mike ; Moreno, Raul</creator><creatorcontrib>Algowhary, Magdy ; Uguz, Berat ; Oliveira, Dinaldo C ; Zimbakov, Zan ; Cercek, Miha ; Loh, Poay Huan ; Calmac, Lucian ; Roura-Ferrer, Gerard ; Quadros, Alexandre ; Scotto di Uccio, Fortunato ; von Birgelen, Clemens ; Versaci, Francesco ; Ten Berg, Jurriën ; Casella, Gianni ; Wong, Aaron Sung Lung ; Kala, Petr ; Carrillo, Xavier ; Dirksen, Maurits Theodoor ; Becerra-Muñoz, Víctor Manuel ; Kang-yin Lee, Michael ; Juzar, Dafsah A ; de Moura Joaquim, Rodrigo ; Bakraceski, Nikola ; Zilio, Filippo ; Kraaijeveld, Adriaan O ; Galasso, Gennaro ; Lux, Arpad ; Marinucci, Lucia ; Guiducci, Vincenzo ; Scoccia, Alessandra ; Ugur Mert, Kadir ; Flores Rios, Xacobe ; Kovarnik, Tomas ; Kidawa, Michal ; Moreu, Jose ; Flavien, Vincent ; Fabris, Enrico ; Lozano Martìnez-Luengas, Iñigo ; Boccalatte, Marco ; Bosa Ojeda, Francisco ; Arellano-Serrano, Carlos ; Caiazzo, Gianluca ; Cirrincione, Giuseppe ; Kao, Hsien-Li ; Sanchis Fores, Juan ; Vignali, Luigi ; Pereira, Helder ; Manzo-Silberman, Stéphane ; Özkan, Alev Arat ; Scheller, Bruno ; Lehtola, Heidi ; Teles, Rui ; Mantis, Christos ; Ylitalo, Antti ; Brum Silveira, Joao Antonio ; Zoni, Rodrigo ; Bessonov, Ivan ; Savonitto, Stefano ; Kochiadakis, George ; Alexopoulos, Dimitrios ; Uribe, Carlos ; Kanakakis, John ; Faurie, Benjamin ; Gabrielli, Gabriele ; Gutiérrez, Alejandro ; Bachini, Juan Pablo ; Tam, Franckie CC ; Rodriguez, Alfredo ; Lukito, Antonia ; Saint-Joy, Veauthyelau ; Pessah, Gustavo ; Tuccillo, Bernardino ; Cortese, Giuliana ; Parodi, Guido ; Bouraghda, Mohamed Abed ; Kedhi, Elvin ; Lamelas, Pablo ; Nardin, Matteo ; Verdoia, Monica ; Kinnaird, Tim ; Cottin, Yves ; Ijsselmuiden, Alexander ; Royaards, Kees-Jan ; Siviglia, Massimo ; Amoroso, Giovanni ; Banning, Adrian ; Santucci, Andrea ; Spedicato, Leonardo ; Mehilli, Julinda ; Levesque, Sébastien ; Ludman, Peter ; Deharo, Pierre ; Benit, Edouard ; Agostoni, Pierfrancesco ; Camacho-Freiere, Santiago ; Brouwer, Marc ; Wilbert, Bor ; Smits, Pieter ; Laine, Mike ; Moreno, Raul ; ISACS-STEMI COVID-19 ; Collaborators</creatorcontrib><description>ObjectiveThe initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days).MethodsThis is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, South-East Asia and North Africa, enrolling 16 674 patients with ST segment elevation myocardial infarction (STEMI) undergoing PPPCI in March/June 2019 and 2020. The main study outcomes were the incidence of PPCI, delayed treatment (ischaemia time >12 hours and door-to-balloon >30 min), in-hospital and 30-day mortality.ResultsIn 2020, during the pandemic, there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio 0.843, 95% CI 0.825 to 0.861, p<0.0001). This reduction was significantly associated with age, being higher in older adults (>75 years) (p=0.015), and was not related to the peak of cases or deaths due to COVID-19. The heterogeneity among centres was high (p<0.001). Furthermore, the pandemic was associated with a significant increase in door-to-balloon time (40 (25–70) min vs 40 (25–64) min, p=0.01) and total ischaemia time (225 (135–410) min vs 196 (120–355) min, p<0.001), which may have contributed to the higher in-hospital (6.5% vs 5.3%, p<0.001) and 30-day (8% vs 6.5%, p=0.001) mortality observed during the pandemic.ConclusionPercutaneous revascularisation for STEMI was significantly affected by the COVID-19 pandemic, with a 16% reduction in PPCI procedures, especially among older patients (about 20%), and longer delays to treatment, which may have contributed to the increased in-hospital and 30-day mortality during the pandemic.Trial registration number NCT04412655.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2021-319750</identifier><identifier>PMID: 34711661</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Acute coronary syndromes ; Age ; Aged ; Angioplasty ; Cardiologists - trends ; Cardiovascular disease ; Coronary Artery Disease ; Coronaviruses ; COVID-19 ; Diabetes ; Female ; Gender ; Heart attacks ; Hospital Mortality - trends ; Humans ; Hypertension ; Incidence ; Ischemia ; Male ; Middle Aged ; Mortality ; myocardial infarction ; Pandemics ; Patients ; percutaneous coronary intervention ; Percutaneous Coronary Intervention - adverse effects ; Percutaneous Coronary Intervention - mortality ; Percutaneous Coronary Intervention - trends ; Practice Patterns, Physicians' - trends ; Registries ; Regression analysis ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Software ; ST Elevation Myocardial Infarction - diagnosis ; ST Elevation Myocardial Infarction - mortality ; ST Elevation Myocardial Infarction - therapy ; Time Factors ; Time-to-Treatment - trends ; Treatment Outcome ; Variance analysis</subject><ispartof>Heart (British Cardiac Society), 2022-03, Vol.108 (6), p.458-466</ispartof><rights>Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>This article is made freely available for personal use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained. https://bmj.com/coronavirus/usage</rights><rights>Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b543t-e460ee5499d17691627354a211a791c97c63df8973fe056af7507717e57b7c393</citedby><cites>FETCH-LOGICAL-b543t-e460ee5499d17691627354a211a791c97c63df8973fe056af7507717e57b7c393</cites><orcidid>0000-0002-5128-2832 ; 0000-0002-9718-9107 ; 0000-0002-0826-1155 ; 0000-0003-0797-8709 ; 0000-0001-6506-8397 ; 0000-0001-9458-0736 ; 0000-0002-3263-4054 ; 0000-0001-6691-8859 ; 0000-0003-2008-3870 ; 0000-0001-6031-2899 ; 0000-0001-9921-8023</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561823/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561823/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34711661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Algowhary, Magdy</creatorcontrib><creatorcontrib>Uguz, Berat</creatorcontrib><creatorcontrib>Oliveira, Dinaldo C</creatorcontrib><creatorcontrib>Zimbakov, Zan</creatorcontrib><creatorcontrib>Cercek, Miha</creatorcontrib><creatorcontrib>Loh, Poay Huan</creatorcontrib><creatorcontrib>Calmac, Lucian</creatorcontrib><creatorcontrib>Roura-Ferrer, Gerard</creatorcontrib><creatorcontrib>Quadros, Alexandre</creatorcontrib><creatorcontrib>Scotto di Uccio, Fortunato</creatorcontrib><creatorcontrib>von Birgelen, Clemens</creatorcontrib><creatorcontrib>Versaci, Francesco</creatorcontrib><creatorcontrib>Ten Berg, Jurriën</creatorcontrib><creatorcontrib>Casella, Gianni</creatorcontrib><creatorcontrib>Wong, Aaron Sung Lung</creatorcontrib><creatorcontrib>Kala, Petr</creatorcontrib><creatorcontrib>Carrillo, Xavier</creatorcontrib><creatorcontrib>Dirksen, Maurits Theodoor</creatorcontrib><creatorcontrib>Becerra-Muñoz, Víctor Manuel</creatorcontrib><creatorcontrib>Kang-yin Lee, Michael</creatorcontrib><creatorcontrib>Juzar, Dafsah A</creatorcontrib><creatorcontrib>de Moura Joaquim, Rodrigo</creatorcontrib><creatorcontrib>Bakraceski, Nikola</creatorcontrib><creatorcontrib>Zilio, Filippo</creatorcontrib><creatorcontrib>Kraaijeveld, Adriaan O</creatorcontrib><creatorcontrib>Galasso, Gennaro</creatorcontrib><creatorcontrib>Lux, Arpad</creatorcontrib><creatorcontrib>Marinucci, Lucia</creatorcontrib><creatorcontrib>Guiducci, Vincenzo</creatorcontrib><creatorcontrib>Scoccia, Alessandra</creatorcontrib><creatorcontrib>Ugur Mert, Kadir</creatorcontrib><creatorcontrib>Flores Rios, Xacobe</creatorcontrib><creatorcontrib>Kovarnik, Tomas</creatorcontrib><creatorcontrib>Kidawa, Michal</creatorcontrib><creatorcontrib>Moreu, Jose</creatorcontrib><creatorcontrib>Flavien, Vincent</creatorcontrib><creatorcontrib>Fabris, Enrico</creatorcontrib><creatorcontrib>Lozano Martìnez-Luengas, Iñigo</creatorcontrib><creatorcontrib>Boccalatte, Marco</creatorcontrib><creatorcontrib>Bosa Ojeda, Francisco</creatorcontrib><creatorcontrib>Arellano-Serrano, Carlos</creatorcontrib><creatorcontrib>Caiazzo, Gianluca</creatorcontrib><creatorcontrib>Cirrincione, Giuseppe</creatorcontrib><creatorcontrib>Kao, Hsien-Li</creatorcontrib><creatorcontrib>Sanchis Fores, Juan</creatorcontrib><creatorcontrib>Vignali, Luigi</creatorcontrib><creatorcontrib>Pereira, Helder</creatorcontrib><creatorcontrib>Manzo-Silberman, Stéphane</creatorcontrib><creatorcontrib>Özkan, Alev Arat</creatorcontrib><creatorcontrib>Scheller, Bruno</creatorcontrib><creatorcontrib>Lehtola, Heidi</creatorcontrib><creatorcontrib>Teles, Rui</creatorcontrib><creatorcontrib>Mantis, Christos</creatorcontrib><creatorcontrib>Ylitalo, Antti</creatorcontrib><creatorcontrib>Brum Silveira, Joao Antonio</creatorcontrib><creatorcontrib>Zoni, Rodrigo</creatorcontrib><creatorcontrib>Bessonov, Ivan</creatorcontrib><creatorcontrib>Savonitto, Stefano</creatorcontrib><creatorcontrib>Kochiadakis, George</creatorcontrib><creatorcontrib>Alexopoulos, Dimitrios</creatorcontrib><creatorcontrib>Uribe, Carlos</creatorcontrib><creatorcontrib>Kanakakis, John</creatorcontrib><creatorcontrib>Faurie, Benjamin</creatorcontrib><creatorcontrib>Gabrielli, Gabriele</creatorcontrib><creatorcontrib>Gutiérrez, Alejandro</creatorcontrib><creatorcontrib>Bachini, Juan Pablo</creatorcontrib><creatorcontrib>Tam, Franckie CC</creatorcontrib><creatorcontrib>Rodriguez, Alfredo</creatorcontrib><creatorcontrib>Lukito, Antonia</creatorcontrib><creatorcontrib>Saint-Joy, Veauthyelau</creatorcontrib><creatorcontrib>Pessah, Gustavo</creatorcontrib><creatorcontrib>Tuccillo, Bernardino</creatorcontrib><creatorcontrib>Cortese, Giuliana</creatorcontrib><creatorcontrib>Parodi, Guido</creatorcontrib><creatorcontrib>Bouraghda, Mohamed Abed</creatorcontrib><creatorcontrib>Kedhi, Elvin</creatorcontrib><creatorcontrib>Lamelas, Pablo</creatorcontrib><creatorcontrib>Nardin, Matteo</creatorcontrib><creatorcontrib>Verdoia, Monica</creatorcontrib><creatorcontrib>Kinnaird, Tim</creatorcontrib><creatorcontrib>Cottin, Yves</creatorcontrib><creatorcontrib>Ijsselmuiden, Alexander</creatorcontrib><creatorcontrib>Royaards, Kees-Jan</creatorcontrib><creatorcontrib>Siviglia, Massimo</creatorcontrib><creatorcontrib>Amoroso, Giovanni</creatorcontrib><creatorcontrib>Banning, Adrian</creatorcontrib><creatorcontrib>Santucci, Andrea</creatorcontrib><creatorcontrib>Spedicato, Leonardo</creatorcontrib><creatorcontrib>Mehilli, Julinda</creatorcontrib><creatorcontrib>Levesque, Sébastien</creatorcontrib><creatorcontrib>Ludman, Peter</creatorcontrib><creatorcontrib>Deharo, Pierre</creatorcontrib><creatorcontrib>Benit, Edouard</creatorcontrib><creatorcontrib>Agostoni, Pierfrancesco</creatorcontrib><creatorcontrib>Camacho-Freiere, Santiago</creatorcontrib><creatorcontrib>Brouwer, Marc</creatorcontrib><creatorcontrib>Wilbert, Bor</creatorcontrib><creatorcontrib>Smits, Pieter</creatorcontrib><creatorcontrib>Laine, Mike</creatorcontrib><creatorcontrib>Moreno, Raul</creatorcontrib><creatorcontrib>ISACS-STEMI COVID-19</creatorcontrib><creatorcontrib>Collaborators</creatorcontrib><title>COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><addtitle>Heart</addtitle><description>ObjectiveThe initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days).MethodsThis is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, South-East Asia and North Africa, enrolling 16 674 patients with ST segment elevation myocardial infarction (STEMI) undergoing PPPCI in March/June 2019 and 2020. The main study outcomes were the incidence of PPCI, delayed treatment (ischaemia time >12 hours and door-to-balloon >30 min), in-hospital and 30-day mortality.ResultsIn 2020, during the pandemic, there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio 0.843, 95% CI 0.825 to 0.861, p<0.0001). This reduction was significantly associated with age, being higher in older adults (>75 years) (p=0.015), and was not related to the peak of cases or deaths due to COVID-19. The heterogeneity among centres was high (p<0.001). Furthermore, the pandemic was associated with a significant increase in door-to-balloon time (40 (25–70) min vs 40 (25–64) min, p=0.01) and total ischaemia time (225 (135–410) min vs 196 (120–355) min, p<0.001), which may have contributed to the higher in-hospital (6.5% vs 5.3%, p<0.001) and 30-day (8% vs 6.5%, p=0.001) mortality observed during the pandemic.ConclusionPercutaneous revascularisation for STEMI was significantly affected by the COVID-19 pandemic, with a 16% reduction in PPCI procedures, especially among older patients (about 20%), and longer delays to treatment, which may have contributed to the increased in-hospital and 30-day mortality during the pandemic.Trial registration number NCT04412655.</description><subject>Acute coronary syndromes</subject><subject>Age</subject><subject>Aged</subject><subject>Angioplasty</subject><subject>Cardiologists - trends</subject><subject>Cardiovascular disease</subject><subject>Coronary Artery Disease</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>Diabetes</subject><subject>Female</subject><subject>Gender</subject><subject>Heart attacks</subject><subject>Hospital Mortality - trends</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Incidence</subject><subject>Ischemia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>myocardial infarction</subject><subject>Pandemics</subject><subject>Patients</subject><subject>percutaneous coronary intervention</subject><subject>Percutaneous Coronary Intervention - adverse effects</subject><subject>Percutaneous Coronary Intervention - mortality</subject><subject>Percutaneous Coronary Intervention - trends</subject><subject>Practice Patterns, Physicians' - trends</subject><subject>Registries</subject><subject>Regression analysis</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Software</subject><subject>ST Elevation Myocardial Infarction - diagnosis</subject><subject>ST Elevation Myocardial Infarction - mortality</subject><subject>ST Elevation Myocardial Infarction - therapy</subject><subject>Time Factors</subject><subject>Time-to-Treatment - trends</subject><subject>Treatment Outcome</subject><subject>Variance analysis</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1v1DAQhiMEoqXwDxCyxIUDoZ74K74gVctXpUo9tCBulteZsF4l9mInlfbf19G2pXDgZGvmmXf8-q2q10A_ADB5ukGbpm0Y6oY2UDPQStAn1TFw2ZYS_Hxa7kyIWlKmjqoXOW8ppVy38nl1xLgCkBKOq251-eP8Uw2a7GzocPTuPRnRbWzwzg4k4Q5TP2cfAyl9wmjd2T0ZY5rs4Kc98YFcXRMc8MZOCzTuo7Op82XWh94mt1RfVs96O2R8dXeeVN-_fL5efasvLr-er84u6rXgbKqRS4oouNYdKKlBNooJbhsAqzQ4rZxkXd9qxXqkQtq-OFYKFAq1Vo5pdlJ9POju5vWIncMwJTuYXfKjTXsTrTd_d4LfmF_xxrRCQtuwIvDuTiDF3zPmyYw-OxwGGzDO2TRCU2jKJl7Qt_-g2zinUOyZRjIGrPz2IsgPlEsx54T9w2OAmiVGcx-jWWI0hxjL2JvHRh6G7nMrAD0A63H7Z_F_NW8Bo9aprA</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Algowhary, Magdy</creator><creator>Uguz, Berat</creator><creator>Oliveira, Dinaldo C</creator><creator>Zimbakov, Zan</creator><creator>Cercek, Miha</creator><creator>Loh, Poay Huan</creator><creator>Calmac, Lucian</creator><creator>Roura-Ferrer, Gerard</creator><creator>Quadros, Alexandre</creator><creator>Scotto di Uccio, Fortunato</creator><creator>von Birgelen, Clemens</creator><creator>Versaci, Francesco</creator><creator>Ten Berg, Jurriën</creator><creator>Casella, Gianni</creator><creator>Wong, Aaron Sung Lung</creator><creator>Kala, Petr</creator><creator>Carrillo, Xavier</creator><creator>Dirksen, Maurits Theodoor</creator><creator>Becerra-Muñoz, Víctor Manuel</creator><creator>Kang-yin Lee, Michael</creator><creator>Juzar, Dafsah A</creator><creator>de Moura Joaquim, Rodrigo</creator><creator>Bakraceski, Nikola</creator><creator>Zilio, Filippo</creator><creator>Kraaijeveld, Adriaan O</creator><creator>Galasso, Gennaro</creator><creator>Lux, Arpad</creator><creator>Marinucci, Lucia</creator><creator>Guiducci, Vincenzo</creator><creator>Scoccia, Alessandra</creator><creator>Ugur Mert, Kadir</creator><creator>Flores Rios, Xacobe</creator><creator>Kovarnik, Tomas</creator><creator>Kidawa, Michal</creator><creator>Moreu, Jose</creator><creator>Flavien, Vincent</creator><creator>Fabris, Enrico</creator><creator>Lozano Martìnez-Luengas, Iñigo</creator><creator>Boccalatte, Marco</creator><creator>Bosa Ojeda, Francisco</creator><creator>Arellano-Serrano, Carlos</creator><creator>Caiazzo, Gianluca</creator><creator>Cirrincione, Giuseppe</creator><creator>Kao, Hsien-Li</creator><creator>Sanchis Fores, Juan</creator><creator>Vignali, Luigi</creator><creator>Pereira, Helder</creator><creator>Manzo-Silberman, Stéphane</creator><creator>Özkan, Alev Arat</creator><creator>Scheller, Bruno</creator><creator>Lehtola, Heidi</creator><creator>Teles, Rui</creator><creator>Mantis, Christos</creator><creator>Ylitalo, Antti</creator><creator>Brum Silveira, Joao Antonio</creator><creator>Zoni, Rodrigo</creator><creator>Bessonov, Ivan</creator><creator>Savonitto, Stefano</creator><creator>Kochiadakis, George</creator><creator>Alexopoulos, Dimitrios</creator><creator>Uribe, Carlos</creator><creator>Kanakakis, John</creator><creator>Faurie, Benjamin</creator><creator>Gabrielli, Gabriele</creator><creator>Gutiérrez, Alejandro</creator><creator>Bachini, Juan Pablo</creator><creator>Tam, Franckie CC</creator><creator>Rodriguez, Alfredo</creator><creator>Lukito, Antonia</creator><creator>Saint-Joy, Veauthyelau</creator><creator>Pessah, Gustavo</creator><creator>Tuccillo, Bernardino</creator><creator>Cortese, Giuliana</creator><creator>Parodi, Guido</creator><creator>Bouraghda, Mohamed Abed</creator><creator>Kedhi, Elvin</creator><creator>Lamelas, Pablo</creator><creator>Nardin, Matteo</creator><creator>Verdoia, Monica</creator><creator>Kinnaird, Tim</creator><creator>Cottin, Yves</creator><creator>Ijsselmuiden, Alexander</creator><creator>Royaards, Kees-Jan</creator><creator>Siviglia, Massimo</creator><creator>Amoroso, Giovanni</creator><creator>Banning, Adrian</creator><creator>Santucci, Andrea</creator><creator>Spedicato, Leonardo</creator><creator>Mehilli, Julinda</creator><creator>Levesque, Sébastien</creator><creator>Ludman, Peter</creator><creator>Deharo, Pierre</creator><creator>Benit, Edouard</creator><creator>Agostoni, Pierfrancesco</creator><creator>Camacho-Freiere, Santiago</creator><creator>Brouwer, Marc</creator><creator>Wilbert, Bor</creator><creator>Smits, Pieter</creator><creator>Laine, Mike</creator><creator>Moreno, Raul</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5128-2832</orcidid><orcidid>https://orcid.org/0000-0002-9718-9107</orcidid><orcidid>https://orcid.org/0000-0002-0826-1155</orcidid><orcidid>https://orcid.org/0000-0003-0797-8709</orcidid><orcidid>https://orcid.org/0000-0001-6506-8397</orcidid><orcidid>https://orcid.org/0000-0001-9458-0736</orcidid><orcidid>https://orcid.org/0000-0002-3263-4054</orcidid><orcidid>https://orcid.org/0000-0001-6691-8859</orcidid><orcidid>https://orcid.org/0000-0003-2008-3870</orcidid><orcidid>https://orcid.org/0000-0001-6031-2899</orcidid><orcidid>https://orcid.org/0000-0001-9921-8023</orcidid></search><sort><creationdate>20220301</creationdate><title>COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction</title><author>Algowhary, Magdy ; Uguz, Berat ; Oliveira, Dinaldo C ; Zimbakov, Zan ; Cercek, Miha ; Loh, Poay Huan ; Calmac, Lucian ; Roura-Ferrer, Gerard ; Quadros, Alexandre ; Scotto di Uccio, Fortunato ; von Birgelen, Clemens ; Versaci, Francesco ; Ten Berg, Jurriën ; Casella, Gianni ; Wong, Aaron Sung Lung ; Kala, Petr ; Carrillo, Xavier ; Dirksen, Maurits Theodoor ; Becerra-Muñoz, Víctor Manuel ; Kang-yin Lee, Michael ; Juzar, Dafsah A ; de Moura Joaquim, Rodrigo ; Bakraceski, Nikola ; Zilio, Filippo ; Kraaijeveld, Adriaan O ; Galasso, Gennaro ; Lux, Arpad ; Marinucci, Lucia ; Guiducci, Vincenzo ; Scoccia, Alessandra ; Ugur Mert, Kadir ; Flores Rios, Xacobe ; Kovarnik, Tomas ; Kidawa, Michal ; Moreu, Jose ; Flavien, Vincent ; Fabris, Enrico ; Lozano Martìnez-Luengas, Iñigo ; Boccalatte, Marco ; Bosa Ojeda, Francisco ; Arellano-Serrano, Carlos ; Caiazzo, Gianluca ; Cirrincione, Giuseppe ; Kao, Hsien-Li ; Sanchis Fores, Juan ; Vignali, Luigi ; Pereira, Helder ; Manzo-Silberman, Stéphane ; Özkan, Alev Arat ; Scheller, Bruno ; Lehtola, Heidi ; Teles, Rui ; Mantis, Christos ; Ylitalo, Antti ; Brum Silveira, Joao Antonio ; Zoni, Rodrigo ; Bessonov, Ivan ; Savonitto, Stefano ; Kochiadakis, George ; Alexopoulos, Dimitrios ; Uribe, Carlos ; Kanakakis, John ; Faurie, Benjamin ; Gabrielli, Gabriele ; Gutiérrez, Alejandro ; Bachini, Juan Pablo ; Tam, Franckie CC ; Rodriguez, Alfredo ; Lukito, Antonia ; Saint-Joy, Veauthyelau ; Pessah, Gustavo ; Tuccillo, Bernardino ; Cortese, Giuliana ; Parodi, Guido ; Bouraghda, Mohamed Abed ; Kedhi, Elvin ; Lamelas, Pablo ; Nardin, Matteo ; Verdoia, Monica ; Kinnaird, Tim ; Cottin, Yves ; Ijsselmuiden, Alexander ; Royaards, Kees-Jan ; Siviglia, Massimo ; Amoroso, Giovanni ; Banning, Adrian ; Santucci, Andrea ; Spedicato, Leonardo ; Mehilli, Julinda ; Levesque, Sébastien ; Ludman, Peter ; Deharo, Pierre ; Benit, Edouard ; Agostoni, Pierfrancesco ; Camacho-Freiere, Santiago ; Brouwer, Marc ; Wilbert, Bor ; Smits, Pieter ; Laine, Mike ; Moreno, Raul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b543t-e460ee5499d17691627354a211a791c97c63df8973fe056af7507717e57b7c393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acute coronary syndromes</topic><topic>Age</topic><topic>Aged</topic><topic>Angioplasty</topic><topic>Cardiologists - trends</topic><topic>Cardiovascular disease</topic><topic>Coronary Artery Disease</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>Diabetes</topic><topic>Female</topic><topic>Gender</topic><topic>Heart attacks</topic><topic>Hospital Mortality - trends</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Incidence</topic><topic>Ischemia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>myocardial infarction</topic><topic>Pandemics</topic><topic>Patients</topic><topic>percutaneous coronary intervention</topic><topic>Percutaneous Coronary Intervention - adverse effects</topic><topic>Percutaneous Coronary Intervention - mortality</topic><topic>Percutaneous Coronary Intervention - trends</topic><topic>Practice Patterns, Physicians' - trends</topic><topic>Registries</topic><topic>Regression analysis</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Software</topic><topic>ST Elevation Myocardial Infarction - diagnosis</topic><topic>ST Elevation Myocardial Infarction - mortality</topic><topic>ST Elevation Myocardial Infarction - therapy</topic><topic>Time Factors</topic><topic>Time-to-Treatment - trends</topic><topic>Treatment Outcome</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Algowhary, Magdy</creatorcontrib><creatorcontrib>Uguz, Berat</creatorcontrib><creatorcontrib>Oliveira, Dinaldo C</creatorcontrib><creatorcontrib>Zimbakov, Zan</creatorcontrib><creatorcontrib>Cercek, Miha</creatorcontrib><creatorcontrib>Loh, Poay Huan</creatorcontrib><creatorcontrib>Calmac, Lucian</creatorcontrib><creatorcontrib>Roura-Ferrer, Gerard</creatorcontrib><creatorcontrib>Quadros, Alexandre</creatorcontrib><creatorcontrib>Scotto di Uccio, Fortunato</creatorcontrib><creatorcontrib>von Birgelen, Clemens</creatorcontrib><creatorcontrib>Versaci, Francesco</creatorcontrib><creatorcontrib>Ten Berg, Jurriën</creatorcontrib><creatorcontrib>Casella, Gianni</creatorcontrib><creatorcontrib>Wong, Aaron Sung Lung</creatorcontrib><creatorcontrib>Kala, Petr</creatorcontrib><creatorcontrib>Carrillo, Xavier</creatorcontrib><creatorcontrib>Dirksen, Maurits Theodoor</creatorcontrib><creatorcontrib>Becerra-Muñoz, Víctor Manuel</creatorcontrib><creatorcontrib>Kang-yin Lee, Michael</creatorcontrib><creatorcontrib>Juzar, Dafsah A</creatorcontrib><creatorcontrib>de Moura Joaquim, Rodrigo</creatorcontrib><creatorcontrib>Bakraceski, Nikola</creatorcontrib><creatorcontrib>Zilio, Filippo</creatorcontrib><creatorcontrib>Kraaijeveld, Adriaan O</creatorcontrib><creatorcontrib>Galasso, Gennaro</creatorcontrib><creatorcontrib>Lux, Arpad</creatorcontrib><creatorcontrib>Marinucci, Lucia</creatorcontrib><creatorcontrib>Guiducci, Vincenzo</creatorcontrib><creatorcontrib>Scoccia, Alessandra</creatorcontrib><creatorcontrib>Ugur Mert, Kadir</creatorcontrib><creatorcontrib>Flores Rios, Xacobe</creatorcontrib><creatorcontrib>Kovarnik, Tomas</creatorcontrib><creatorcontrib>Kidawa, Michal</creatorcontrib><creatorcontrib>Moreu, Jose</creatorcontrib><creatorcontrib>Flavien, Vincent</creatorcontrib><creatorcontrib>Fabris, Enrico</creatorcontrib><creatorcontrib>Lozano Martìnez-Luengas, Iñigo</creatorcontrib><creatorcontrib>Boccalatte, Marco</creatorcontrib><creatorcontrib>Bosa Ojeda, Francisco</creatorcontrib><creatorcontrib>Arellano-Serrano, Carlos</creatorcontrib><creatorcontrib>Caiazzo, Gianluca</creatorcontrib><creatorcontrib>Cirrincione, Giuseppe</creatorcontrib><creatorcontrib>Kao, Hsien-Li</creatorcontrib><creatorcontrib>Sanchis Fores, Juan</creatorcontrib><creatorcontrib>Vignali, Luigi</creatorcontrib><creatorcontrib>Pereira, Helder</creatorcontrib><creatorcontrib>Manzo-Silberman, Stéphane</creatorcontrib><creatorcontrib>Özkan, Alev Arat</creatorcontrib><creatorcontrib>Scheller, Bruno</creatorcontrib><creatorcontrib>Lehtola, Heidi</creatorcontrib><creatorcontrib>Teles, Rui</creatorcontrib><creatorcontrib>Mantis, Christos</creatorcontrib><creatorcontrib>Ylitalo, Antti</creatorcontrib><creatorcontrib>Brum Silveira, Joao Antonio</creatorcontrib><creatorcontrib>Zoni, Rodrigo</creatorcontrib><creatorcontrib>Bessonov, Ivan</creatorcontrib><creatorcontrib>Savonitto, Stefano</creatorcontrib><creatorcontrib>Kochiadakis, George</creatorcontrib><creatorcontrib>Alexopoulos, Dimitrios</creatorcontrib><creatorcontrib>Uribe, Carlos</creatorcontrib><creatorcontrib>Kanakakis, John</creatorcontrib><creatorcontrib>Faurie, Benjamin</creatorcontrib><creatorcontrib>Gabrielli, Gabriele</creatorcontrib><creatorcontrib>Gutiérrez, Alejandro</creatorcontrib><creatorcontrib>Bachini, Juan Pablo</creatorcontrib><creatorcontrib>Tam, Franckie CC</creatorcontrib><creatorcontrib>Rodriguez, Alfredo</creatorcontrib><creatorcontrib>Lukito, Antonia</creatorcontrib><creatorcontrib>Saint-Joy, Veauthyelau</creatorcontrib><creatorcontrib>Pessah, Gustavo</creatorcontrib><creatorcontrib>Tuccillo, Bernardino</creatorcontrib><creatorcontrib>Cortese, Giuliana</creatorcontrib><creatorcontrib>Parodi, Guido</creatorcontrib><creatorcontrib>Bouraghda, Mohamed Abed</creatorcontrib><creatorcontrib>Kedhi, Elvin</creatorcontrib><creatorcontrib>Lamelas, Pablo</creatorcontrib><creatorcontrib>Nardin, Matteo</creatorcontrib><creatorcontrib>Verdoia, Monica</creatorcontrib><creatorcontrib>Kinnaird, Tim</creatorcontrib><creatorcontrib>Cottin, Yves</creatorcontrib><creatorcontrib>Ijsselmuiden, Alexander</creatorcontrib><creatorcontrib>Royaards, Kees-Jan</creatorcontrib><creatorcontrib>Siviglia, Massimo</creatorcontrib><creatorcontrib>Amoroso, Giovanni</creatorcontrib><creatorcontrib>Banning, Adrian</creatorcontrib><creatorcontrib>Santucci, Andrea</creatorcontrib><creatorcontrib>Spedicato, Leonardo</creatorcontrib><creatorcontrib>Mehilli, Julinda</creatorcontrib><creatorcontrib>Levesque, Sébastien</creatorcontrib><creatorcontrib>Ludman, Peter</creatorcontrib><creatorcontrib>Deharo, Pierre</creatorcontrib><creatorcontrib>Benit, Edouard</creatorcontrib><creatorcontrib>Agostoni, Pierfrancesco</creatorcontrib><creatorcontrib>Camacho-Freiere, Santiago</creatorcontrib><creatorcontrib>Brouwer, Marc</creatorcontrib><creatorcontrib>Wilbert, Bor</creatorcontrib><creatorcontrib>Smits, Pieter</creatorcontrib><creatorcontrib>Laine, Mike</creatorcontrib><creatorcontrib>Moreno, Raul</creatorcontrib><creatorcontrib>ISACS-STEMI COVID-19</creatorcontrib><creatorcontrib>Collaborators</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Algowhary, Magdy</au><au>Uguz, Berat</au><au>Oliveira, Dinaldo C</au><au>Zimbakov, Zan</au><au>Cercek, Miha</au><au>Loh, Poay Huan</au><au>Calmac, Lucian</au><au>Roura-Ferrer, Gerard</au><au>Quadros, Alexandre</au><au>Scotto di Uccio, Fortunato</au><au>von Birgelen, Clemens</au><au>Versaci, Francesco</au><au>Ten Berg, Jurriën</au><au>Casella, Gianni</au><au>Wong, Aaron Sung Lung</au><au>Kala, Petr</au><au>Carrillo, Xavier</au><au>Dirksen, Maurits Theodoor</au><au>Becerra-Muñoz, Víctor Manuel</au><au>Kang-yin Lee, Michael</au><au>Juzar, Dafsah A</au><au>de Moura Joaquim, Rodrigo</au><au>Bakraceski, Nikola</au><au>Zilio, Filippo</au><au>Kraaijeveld, Adriaan O</au><au>Galasso, Gennaro</au><au>Lux, Arpad</au><au>Marinucci, Lucia</au><au>Guiducci, Vincenzo</au><au>Scoccia, Alessandra</au><au>Ugur Mert, Kadir</au><au>Flores Rios, Xacobe</au><au>Kovarnik, Tomas</au><au>Kidawa, Michal</au><au>Moreu, Jose</au><au>Flavien, Vincent</au><au>Fabris, Enrico</au><au>Lozano Martìnez-Luengas, Iñigo</au><au>Boccalatte, Marco</au><au>Bosa Ojeda, Francisco</au><au>Arellano-Serrano, Carlos</au><au>Caiazzo, Gianluca</au><au>Cirrincione, Giuseppe</au><au>Kao, Hsien-Li</au><au>Sanchis Fores, Juan</au><au>Vignali, Luigi</au><au>Pereira, Helder</au><au>Manzo-Silberman, Stéphane</au><au>Özkan, Alev Arat</au><au>Scheller, Bruno</au><au>Lehtola, Heidi</au><au>Teles, Rui</au><au>Mantis, Christos</au><au>Ylitalo, Antti</au><au>Brum Silveira, Joao Antonio</au><au>Zoni, Rodrigo</au><au>Bessonov, Ivan</au><au>Savonitto, Stefano</au><au>Kochiadakis, George</au><au>Alexopoulos, Dimitrios</au><au>Uribe, Carlos</au><au>Kanakakis, John</au><au>Faurie, Benjamin</au><au>Gabrielli, Gabriele</au><au>Gutiérrez, Alejandro</au><au>Bachini, Juan Pablo</au><au>Tam, Franckie CC</au><au>Rodriguez, Alfredo</au><au>Lukito, Antonia</au><au>Saint-Joy, Veauthyelau</au><au>Pessah, Gustavo</au><au>Tuccillo, Bernardino</au><au>Cortese, Giuliana</au><au>Parodi, Guido</au><au>Bouraghda, Mohamed Abed</au><au>Kedhi, Elvin</au><au>Lamelas, Pablo</au><au>Nardin, Matteo</au><au>Verdoia, Monica</au><au>Kinnaird, Tim</au><au>Cottin, Yves</au><au>Ijsselmuiden, Alexander</au><au>Royaards, Kees-Jan</au><au>Siviglia, Massimo</au><au>Amoroso, Giovanni</au><au>Banning, Adrian</au><au>Santucci, Andrea</au><au>Spedicato, Leonardo</au><au>Mehilli, Julinda</au><au>Levesque, Sébastien</au><au>Ludman, Peter</au><au>Deharo, Pierre</au><au>Benit, Edouard</au><au>Agostoni, Pierfrancesco</au><au>Camacho-Freiere, Santiago</au><au>Brouwer, Marc</au><au>Wilbert, Bor</au><au>Smits, Pieter</au><au>Laine, Mike</au><au>Moreno, Raul</au><aucorp>ISACS-STEMI COVID-19</aucorp><aucorp>Collaborators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction</atitle><jtitle>Heart (British Cardiac Society)</jtitle><stitle>Heart</stitle><addtitle>Heart</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>108</volume><issue>6</issue><spage>458</spage><epage>466</epage><pages>458-466</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>ObjectiveThe initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days).MethodsThis is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, South-East Asia and North Africa, enrolling 16 674 patients with ST segment elevation myocardial infarction (STEMI) undergoing PPPCI in March/June 2019 and 2020. The main study outcomes were the incidence of PPCI, delayed treatment (ischaemia time >12 hours and door-to-balloon >30 min), in-hospital and 30-day mortality.ResultsIn 2020, during the pandemic, there was a significant reduction in PPCI as compared with 2019 (incidence rate ratio 0.843, 95% CI 0.825 to 0.861, p<0.0001). This reduction was significantly associated with age, being higher in older adults (>75 years) (p=0.015), and was not related to the peak of cases or deaths due to COVID-19. The heterogeneity among centres was high (p<0.001). Furthermore, the pandemic was associated with a significant increase in door-to-balloon time (40 (25–70) min vs 40 (25–64) min, p=0.01) and total ischaemia time (225 (135–410) min vs 196 (120–355) min, p<0.001), which may have contributed to the higher in-hospital (6.5% vs 5.3%, p<0.001) and 30-day (8% vs 6.5%, p=0.001) mortality observed during the pandemic.ConclusionPercutaneous revascularisation for STEMI was significantly affected by the COVID-19 pandemic, with a 16% reduction in PPCI procedures, especially among older patients (about 20%), and longer delays to treatment, which may have contributed to the increased in-hospital and 30-day mortality during the pandemic.Trial registration number NCT04412655.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><pmid>34711661</pmid><doi>10.1136/heartjnl-2021-319750</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5128-2832</orcidid><orcidid>https://orcid.org/0000-0002-9718-9107</orcidid><orcidid>https://orcid.org/0000-0002-0826-1155</orcidid><orcidid>https://orcid.org/0000-0003-0797-8709</orcidid><orcidid>https://orcid.org/0000-0001-6506-8397</orcidid><orcidid>https://orcid.org/0000-0001-9458-0736</orcidid><orcidid>https://orcid.org/0000-0002-3263-4054</orcidid><orcidid>https://orcid.org/0000-0001-6691-8859</orcidid><orcidid>https://orcid.org/0000-0003-2008-3870</orcidid><orcidid>https://orcid.org/0000-0001-6031-2899</orcidid><orcidid>https://orcid.org/0000-0001-9921-8023</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-6037 |
| ispartof | Heart (British Cardiac Society), 2022-03, Vol.108 (6), p.458-466 |
| issn | 1355-6037 1468-201X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8561823 |
| source | MEDLINE; PubMed Central |
| subjects | Acute coronary syndromes Age Aged Angioplasty Cardiologists - trends Cardiovascular disease Coronary Artery Disease Coronaviruses COVID-19 Diabetes Female Gender Heart attacks Hospital Mortality - trends Humans Hypertension Incidence Ischemia Male Middle Aged Mortality myocardial infarction Pandemics Patients percutaneous coronary intervention Percutaneous Coronary Intervention - adverse effects Percutaneous Coronary Intervention - mortality Percutaneous Coronary Intervention - trends Practice Patterns, Physicians' - trends Registries Regression analysis Retrospective Studies Risk Assessment Risk Factors Software ST Elevation Myocardial Infarction - diagnosis ST Elevation Myocardial Infarction - mortality ST Elevation Myocardial Infarction - therapy Time Factors Time-to-Treatment - trends Treatment Outcome Variance analysis |
| title | COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T06%3A06%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=COVID-19%20pandemic,%20mechanical%20reperfusion%20and%2030-day%20mortality%20in%20ST%20elevation%20myocardial%20infarction&rft.jtitle=Heart%20(British%20Cardiac%20Society)&rft.au=Algowhary,%20Magdy&rft.aucorp=ISACS-STEMI%20COVID-19&rft.date=2022-03-01&rft.volume=108&rft.issue=6&rft.spage=458&rft.epage=466&rft.pages=458-466&rft.issn=1355-6037&rft.eissn=1468-201X&rft_id=info:doi/10.1136/heartjnl-2021-319750&rft_dat=%3Cproquest_pubme%3E2633130003%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2633130003&rft_id=info:pmid/34711661&rfr_iscdi=true |