IL‐20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation

IL‐20 is a proinflammatory cytokine of the IL‐10 family and involved in several diseases. However, the regulatory role of IL‐20 in obesity is not well understood. We explored the function of IL‐20 in the pathogenesis of obesity‐induced insulin resistance by ELISA, Western blotting and flow cytometry...

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Veröffentlicht in:	Immunology 2021-12, Vol.164 (4), p.817-833
Hauptverfasser:	Hsu, Yu‐Hsiang, Wu, Chih‐Hsing, Chiu, Chiao‐Juno, Chen, Wei‐Ting, Chang, Yi‐Chieh, Wabitsch, Martin, Chang, Ming‐Shi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - metabolism Adipogenesis Adipogenesis - genetics Adipose tissue Adult Aged Aged, 80 and over Animal models Animals Biomarkers Body weight Bone marrow Chemotaxis, Leukocyte Cytokines Cytokines - metabolism Diet Disease Models, Animal Disease Susceptibility Female Flow cytometry Gene Expression Glucose Glucose - metabolism Glucose tolerance High fat diet Humans Immunological tolerance Inflammation Insulin Insulin - metabolism Insulin resistance interleukin 20 Interleukins - genetics Interleukins - metabolism Leptin Macrophages Macrophages - immunology Macrophages - metabolism Male Metabolic disorders Mice Middle Aged Monoclonal antibodies Monocyte chemoattractant protein 1 Monocytes Obesity Obesity - etiology Obesity - metabolism Obesity - pathology Original Pathogenesis Patients Signal Transduction Tumor necrosis factor Weight reduction Western blotting
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