CBX8 interacts with chromatin PTEN and is involved in regulating mitotic progression

Objectives Besides its role in regulating phosphatidylinositol‐3 kinase (PI3K) signalling in the cytosol, PTEN also has a nuclear function. In this study, we attempted to understand the mechanism of chromatin PTEN in suppressing chromosomal instability during cell division. Materials and methods Imm...

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Veröffentlicht in:	Cell proliferation 2021-11, Vol.54 (11), p.e13110-n/a
Hauptverfasser:	Choi, Byeong Hyeok, Colon, Tania Marlyn, Lee, Eunji, Kou, Ziyue, Dai, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Antibodies BUBR1 protein CBX8 Cell culture Cell cycle Cell Cycle - physiology Cell division Cell growth Cell proliferation Cell Proliferation - physiology Chromatin Chromatin - metabolism chromatin modifications Chromosomes Cytosol Ectopic expression Epigenetics Gene expression Genomic instability H3K27Me3 Histones Histones - metabolism Homology Humans Immunoblotting Kinases Laboratories Markers MCC Microscopy Mitosis Mitosis - physiology Original Phosphatase Phosphorylation Plasmids Polycomb group proteins Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Polycomb-Group Proteins - genetics Polycomb-Group Proteins - metabolism PRC1 Proteins PTEN PTEN Phosphohydrolase - metabolism PTEN protein siRNA Synchronism Synchronization
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