Gastroesophageal reflux disease: recent innovations in endoscopic assessment and treatment
Abstract Innovations in endoscopy have brought about some impressive improvements in diagnosing and treating gastroesophageal reflux disease (GERD). GERD, as one of the most prevalent gastrointestinal disorders in the world, has always been on the cutting edge of endoscopic interventions. A primary...
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| Veröffentlicht in: | Gastroenterology Report 2021-10, Vol.9 (5), p.383-391 |
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| creator | Chen, Sheng Du, Feng Zhong, Changqing Liu, Caifang Wang, Xiaoying Chen, Yan Wang, Gang Gao, Xiaopei Zhang, Lu Li, Lianyong Wu, Wei |
| description | Abstract
Innovations in endoscopy have brought about some impressive improvements in diagnosing and treating gastroesophageal reflux disease (GERD). GERD, as one of the most prevalent gastrointestinal disorders in the world, has always been on the cutting edge of endoscopic interventions. A primary diagnosis of GERD is based on symptoms and an initial trial of proton-pump inhibitor (PPI) therapy, which is devoid of adequately instructive value for therapeutic strategies. Endoscopy and optional biopsies can be used to directly observe and determine the abnormal structural and pathophysiological damage in the esophagus. The emergence of minimally invasive endoscopic therapy fills the gap between patients who are reluctant or insensitive to PPIs and candidates who are not indicated for surgical anti-reflux fundoplication. In this review, we discuss the utility of endoscopy and biopsy in patients with persistent GERD-related manifestations after proper medical anti-reflux treatment. Moreover, we portray a landscape of four current endoscopic GERD therapies and clarify the merits and disadvantages of each technique. Future research needs to concentrate on stratifying GERD patients based on personal conditions and elucidating the primary pathophysiology of GERD. |
| doi_str_mv | 10.1093/gastro/goab029 |
| format | Article |
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Innovations in endoscopy have brought about some impressive improvements in diagnosing and treating gastroesophageal reflux disease (GERD). GERD, as one of the most prevalent gastrointestinal disorders in the world, has always been on the cutting edge of endoscopic interventions. A primary diagnosis of GERD is based on symptoms and an initial trial of proton-pump inhibitor (PPI) therapy, which is devoid of adequately instructive value for therapeutic strategies. Endoscopy and optional biopsies can be used to directly observe and determine the abnormal structural and pathophysiological damage in the esophagus. The emergence of minimally invasive endoscopic therapy fills the gap between patients who are reluctant or insensitive to PPIs and candidates who are not indicated for surgical anti-reflux fundoplication. In this review, we discuss the utility of endoscopy and biopsy in patients with persistent GERD-related manifestations after proper medical anti-reflux treatment. Moreover, we portray a landscape of four current endoscopic GERD therapies and clarify the merits and disadvantages of each technique. Future research needs to concentrate on stratifying GERD patients based on personal conditions and elucidating the primary pathophysiology of GERD.</description><identifier>ISSN: 2052-0034</identifier><identifier>EISSN: 2052-0034</identifier><identifier>DOI: 10.1093/gastro/goab029</identifier><identifier>PMID: 34733523</identifier><language>eng</language><publisher>OXFORD: Oxford University Press</publisher><subject>Care and treatment ; Diagnosis ; Endoscopy ; Gastroenterology & Hepatology ; Gastroesophageal reflux ; Gastrointestinal agents ; Gastrointestinal diseases ; Health aspects ; Life Sciences & Biomedicine ; Review ; Science & Technology</subject><ispartof>Gastroenterology Report, 2021-10, Vol.9 (5), p.383-391</ispartof><rights>The Author(s) 2021. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University.</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>6</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000717511400002</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c491t-467683eb4cd36ac1bfbfd88c17837a0eccefaab12a08a61b03331e9bec7dda753</citedby><cites>FETCH-LOGICAL-c491t-467683eb4cd36ac1bfbfd88c17837a0eccefaab12a08a61b03331e9bec7dda753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560030/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560030/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,1605,2115,27929,27930,39263,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34733523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Sheng</creatorcontrib><creatorcontrib>Du, Feng</creatorcontrib><creatorcontrib>Zhong, Changqing</creatorcontrib><creatorcontrib>Liu, Caifang</creatorcontrib><creatorcontrib>Wang, Xiaoying</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Wang, Gang</creatorcontrib><creatorcontrib>Gao, Xiaopei</creatorcontrib><creatorcontrib>Zhang, Lu</creatorcontrib><creatorcontrib>Li, Lianyong</creatorcontrib><creatorcontrib>Wu, Wei</creatorcontrib><title>Gastroesophageal reflux disease: recent innovations in endoscopic assessment and treatment</title><title>Gastroenterology Report</title><addtitle>GASTROENTEROL REP</addtitle><addtitle>Gastroenterol Rep (Oxf)</addtitle><description>Abstract
Innovations in endoscopy have brought about some impressive improvements in diagnosing and treating gastroesophageal reflux disease (GERD). GERD, as one of the most prevalent gastrointestinal disorders in the world, has always been on the cutting edge of endoscopic interventions. A primary diagnosis of GERD is based on symptoms and an initial trial of proton-pump inhibitor (PPI) therapy, which is devoid of adequately instructive value for therapeutic strategies. Endoscopy and optional biopsies can be used to directly observe and determine the abnormal structural and pathophysiological damage in the esophagus. The emergence of minimally invasive endoscopic therapy fills the gap between patients who are reluctant or insensitive to PPIs and candidates who are not indicated for surgical anti-reflux fundoplication. In this review, we discuss the utility of endoscopy and biopsy in patients with persistent GERD-related manifestations after proper medical anti-reflux treatment. Moreover, we portray a landscape of four current endoscopic GERD therapies and clarify the merits and disadvantages of each technique. Future research needs to concentrate on stratifying GERD patients based on personal conditions and elucidating the primary pathophysiology of GERD.</description><subject>Care and treatment</subject><subject>Diagnosis</subject><subject>Endoscopy</subject><subject>Gastroenterology & Hepatology</subject><subject>Gastroesophageal reflux</subject><subject>Gastrointestinal agents</subject><subject>Gastrointestinal diseases</subject><subject>Health aspects</subject><subject>Life Sciences & Biomedicine</subject><subject>Review</subject><subject>Science & Technology</subject><issn>2052-0034</issn><issn>2052-0034</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>HGBXW</sourceid><recordid>eNqNUU1LxDAQDaKo6F49Sq8iu5s0bdP1IMjiFwhe9OIlTJJpjXST0nT9-Pdmra56UnLITPLem8c8Qg4YnTA649MaQt_5ae1B0XS2QXZTmqdjSnm2-aPeIaMQniiljIo0Z_k22eGZ4DxP-S55uPzQwODbR6gRmqTDqlm-JsYGhIAnsdfo-sQ655-ht96FWCfojA_at1YnEAKGsFiBwJmk7xD6VbdPtipoAo4-7z1yf3F-N78a39xeXs_PbsY6m7F-nBWiKDmqTBtegGaqUpUpS81EyQVQ1BorAMVSoCUUTFHOOcOZQi2MAZHzPXI66LZLtUCzcttBI9vOLqB7kx6s_P3j7KOs_bMs8yLuh0aBySBQQ4PSuspHmI7H4MJq77Cy8f1MRKNZzpj4JujOhxAXth7GqFwlI4dk5GcykXD40-Ia_pVDBJQD4AWVr4K26DSuYTE7wUQcncWKpnPbfwQx90vXR-rx_6kRfTSg_bL9y_U71EO_LQ</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Chen, Sheng</creator><creator>Du, Feng</creator><creator>Zhong, Changqing</creator><creator>Liu, Caifang</creator><creator>Wang, Xiaoying</creator><creator>Chen, Yan</creator><creator>Wang, Gang</creator><creator>Gao, Xiaopei</creator><creator>Zhang, Lu</creator><creator>Li, Lianyong</creator><creator>Wu, Wei</creator><general>Oxford University Press</general><general>Oxford Univ Press</general><scope>TOX</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>5PM</scope></search><sort><creationdate>20211001</creationdate><title>Gastroesophageal reflux disease: recent innovations in endoscopic assessment and treatment</title><author>Chen, Sheng ; Du, Feng ; Zhong, Changqing ; Liu, Caifang ; Wang, Xiaoying ; Chen, Yan ; Wang, Gang ; Gao, Xiaopei ; Zhang, Lu ; Li, Lianyong ; Wu, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-467683eb4cd36ac1bfbfd88c17837a0eccefaab12a08a61b03331e9bec7dda753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Care and treatment</topic><topic>Diagnosis</topic><topic>Endoscopy</topic><topic>Gastroenterology & Hepatology</topic><topic>Gastroesophageal reflux</topic><topic>Gastrointestinal agents</topic><topic>Gastrointestinal diseases</topic><topic>Health aspects</topic><topic>Life Sciences & Biomedicine</topic><topic>Review</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Sheng</creatorcontrib><creatorcontrib>Du, Feng</creatorcontrib><creatorcontrib>Zhong, Changqing</creatorcontrib><creatorcontrib>Liu, Caifang</creatorcontrib><creatorcontrib>Wang, Xiaoying</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Wang, Gang</creatorcontrib><creatorcontrib>Gao, Xiaopei</creatorcontrib><creatorcontrib>Zhang, Lu</creatorcontrib><creatorcontrib>Li, Lianyong</creatorcontrib><creatorcontrib>Wu, Wei</creatorcontrib><collection>Access via Oxford University Press (Open Access Collection)</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gastroenterology Report</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Sheng</au><au>Du, Feng</au><au>Zhong, Changqing</au><au>Liu, Caifang</au><au>Wang, Xiaoying</au><au>Chen, Yan</au><au>Wang, Gang</au><au>Gao, Xiaopei</au><au>Zhang, Lu</au><au>Li, Lianyong</au><au>Wu, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastroesophageal reflux disease: recent innovations in endoscopic assessment and treatment</atitle><jtitle>Gastroenterology Report</jtitle><stitle>GASTROENTEROL REP</stitle><addtitle>Gastroenterol Rep (Oxf)</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>9</volume><issue>5</issue><spage>383</spage><epage>391</epage><pages>383-391</pages><issn>2052-0034</issn><eissn>2052-0034</eissn><abstract>Abstract
Innovations in endoscopy have brought about some impressive improvements in diagnosing and treating gastroesophageal reflux disease (GERD). GERD, as one of the most prevalent gastrointestinal disorders in the world, has always been on the cutting edge of endoscopic interventions. A primary diagnosis of GERD is based on symptoms and an initial trial of proton-pump inhibitor (PPI) therapy, which is devoid of adequately instructive value for therapeutic strategies. Endoscopy and optional biopsies can be used to directly observe and determine the abnormal structural and pathophysiological damage in the esophagus. The emergence of minimally invasive endoscopic therapy fills the gap between patients who are reluctant or insensitive to PPIs and candidates who are not indicated for surgical anti-reflux fundoplication. In this review, we discuss the utility of endoscopy and biopsy in patients with persistent GERD-related manifestations after proper medical anti-reflux treatment. Moreover, we portray a landscape of four current endoscopic GERD therapies and clarify the merits and disadvantages of each technique. Future research needs to concentrate on stratifying GERD patients based on personal conditions and elucidating the primary pathophysiology of GERD.</abstract><cop>OXFORD</cop><pub>Oxford University Press</pub><pmid>34733523</pmid><doi>10.1093/gastro/goab029</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Care and treatment Diagnosis Endoscopy Gastroenterology & Hepatology Gastroesophageal reflux Gastrointestinal agents Gastrointestinal diseases Health aspects Life Sciences & Biomedicine Review Science & Technology |
| title | Gastroesophageal reflux disease: recent innovations in endoscopic assessment and treatment |
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