Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis

Bumped kinase inhibitors (BKIs) that target Cryptosporidium parvum calcium-dependent protein kinase 1 have been well established as potential drug candidates against cryptosporidiosis. Recently, BKI-1649, with a 7H-pyrrolo­[2,3-d]­pyrimidin-4-amine, or “pyrrolopyrimidine”, central scaffold, has show...

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Veröffentlicht in:	ACS infectious diseases 2021-05, Vol.7 (5), p.1200-1207
Hauptverfasser:	Hulverson, Matthew A, Choi, Ryan, Vidadala, Rama S. R, Whitman, Grant R, Vidadala, Venkata Narayana, Ojo, Kayode K, Barrett, Lynn K, Lynch, James J, Marsh, Kennan, Kempf, Dale J, Maly, Dustin J, Van Voorhis, Wesley C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiprotozoal Agents Cryptosporidiosis - drug therapy Cryptosporidium Mice Protein Kinase Inhibitors - pharmacology Pyrimidines Pyrroles
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