T-Cell Receptor Profiling and Prognosis After Stereotactic Body Radiation Therapy For Stage I Non-Small-Cell Lung Cancer

Radiotherapy is known to influence immune function, including T cell receptor (TCR) repertoire. We evaluated the TCR repertoire before and after stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer (NSCLC) and explored correlations between TCR indexes and distant failure afte...

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Veröffentlicht in:	Frontiers in immunology 2021-10, Vol.12, p.719285-719285, Article 719285
Hauptverfasser:	Wu, Lirong, Zhu, Jun, Rudqvist, Nils-Petter, Welsh, James, Lee, Percy, Liao, Zhongxing, Xu, Ting, Jiang, Ming, Zhu, Xiangzhi, Pan, Xuan, Li, Pansong, Zhou, Zhipeng, He, Xia, Yin, Rong, Feng, Jifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biomarkers Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - radiotherapy disease progression Female Gene Expression Profiling High-Throughput Nucleotide Sequencing Humans Immunology Life Sciences & Biomedicine Lung Neoplasms - diagnosis Lung Neoplasms - genetics Lung Neoplasms - mortality Lung Neoplasms - radiotherapy Male Middle Aged Neoplasm Staging non-small-cell lung cancer Positron Emission Tomography Computed Tomography Prognosis Radiosurgery Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - metabolism ROC Curve Science & Technology stereotactic body radiation therapy T-cell receptor sequencing Tomography, X-Ray Computed treatment failure V(D)J Recombination
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