Mitochondrial disease, mitophagy, and cellular distress in methylmalonic acidemia

Mitochondria—the intracellular powerhouse in which nutrients are converted into energy in the form of ATP or heat—are highly dynamic, double-membraned organelles that harness a plethora of cellular functions that sustain energy metabolism and homeostasis. Exciting new discoveries now indicate that t...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2021-11, Vol.78 (21-22), p.6851-6867
Hauptverfasser:	Luciani, Alessandro, Denley, Matthew C. S., Govers, Larissa P., Sorrentino, Vincenzo, Froese, D. Sean
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Metabolism, Inborn Errors - metabolism Animal models Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cell differentiation Cellular communication Disease Energy metabolism Energy Metabolism - physiology Hereditary diseases Homeostasis Homeostasis - physiology Humans Life Sciences Metabolism Mitochondria Mitochondria - metabolism Mitochondrial Diseases - metabolism Mitophagy Mitophagy - physiology Molecular modelling Nutrients Organelles Organelles - metabolism Oxidative stress Pathophysiology Physiology Review Signal Transduction - physiology
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