Rapid tumor‐labeling kinetics with a site‐specific near‐infrared anti‐CEA nanobody in a patient‐derived orthotopic xenograft mouse model of colon cancer

Background/Objectives Nanobodies are the smallest biologic antigen‐binding fragments derived from camelid‐derived antibodies. Nanobodies effect a peak tumor signal within minutes of injection and present a novel opportunity for fluorescence‐guided surgery (FGS). The present study demonstrates the ef...

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Veröffentlicht in:	Journal of surgical oncology 2021-12, Vol.124 (7), p.1121-1127
Hauptverfasser:	Lwin, Thinzar M., Turner, Michael A., Amirfakhri, Siamak, Nishino, Hiroto, Debie, Pieterjan, Cosman, Bard C., Hoffman, Robert M., Hernot, Sophie, Bouvet, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti‐CEA nanobody Carcinoembryonic Antigen - immunology Colonic Neoplasms - diagnostic imaging Colorectal cancer Disease Models, Animal fluorescence‐guided surgery fluorescent anti‐CEA nanobody Fluorescent Dyes Heterografts Humans Mice Mice, Nude Neoplasms, Experimental Optical Imaging patient‐derived orthotopic xenograft models Single-Domain Antibodies tumor‐specific fluorescence
Online-Zugang:	Volltext
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