Post-stroke cognitive impairment on the Mini-Mental State Examination primarily relates to left middle cerebral artery infarcts

Post-stroke cognitive impairment on the Mini-Mental State Examination primarily relates to left middle cerebral artery infarcts

Background Post-stroke cognitive impairment can occur after damage to various brain regions, and cognitive deficits depend on infarct location. The Mini-Mental State Examination (MMSE) is still widely used to assess post-stroke cognition, but it has been criticized for capturing only certain cogniti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of stroke 2021-10, Vol.16 (8), p.981-989
Hauptverfasser: Weaver, Nick A, Kancheva, Angelina K, Lim, Jae-Sung, Biesbroek, J Matthijs, Wajer, Irene MC Huenges, Kang, Yeonwook, Kim, Beom J, Kuijf, Hugo J, Lee, Byung-Chul, Lee, Keon-Joo, Yu, Kyung-Ho, Biessels, Geert Jan, Bae, Hee-Joon
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 989
container_issue 8
container_start_page 981
container_title International journal of stroke
container_volume 16
creator Weaver, Nick A
Kancheva, Angelina K
Lim, Jae-Sung
Biesbroek, J Matthijs
Wajer, Irene MC Huenges
Kang, Yeonwook
Kim, Beom J
Kuijf, Hugo J
Lee, Byung-Chul
Lee, Keon-Joo
Yu, Kyung-Ho
Biessels, Geert Jan
Bae, Hee-Joon
description Background Post-stroke cognitive impairment can occur after damage to various brain regions, and cognitive deficits depend on infarct location. The Mini-Mental State Examination (MMSE) is still widely used to assess post-stroke cognition, but it has been criticized for capturing only certain cognitive deficits. Along these lines, it might be hypothesized that cognitive deficits as measured with the MMSE primarily involve certain infarct locations. Aims This comprehensive lesion-symptom mapping study aimed to determine which acute infarct locations are associated with post-stroke cognitive impairment on the MMSE. Methods We examined associations between impairment on the MMSE (
doi_str_mv 10.1177/1747493020984552
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8554493</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1747493020984552</sage_id><sourcerecordid>2479747783</sourcerecordid><originalsourceid>FETCH-LOGICAL-c434t-27c182a5384dd96310b53928486a5368ae20f967d80d02ccbc46dd1d1b4282af3</originalsourceid><addsrcrecordid>eNp1UU1P3DAUtKpWhdLee6p85JLir8TOBQkh-iGBqAQ9W479spgm9mJ7EXvqX8erhVVB6snWezPj8QxCnyn5SqmUR1QKKXpOGOmVaFv2Bu1vRo3oRf92d-dkD33I-ZYQ0UrevUd7nAvJWin20d9fMZcmlxT_ALZxEXzx94D9vDQ-zRAKjgGXG8AXPvjmog7MhK-KKYDPHszsgym-IpbJzyb5aY0TTHWZcYl4grHg2Ts3VWlIMKTKNalAWmMfRpNsyR_Ru9FMGT49nQfo97ez69Mfzfnl95-nJ-eNFVyUhklLFTMtV8K5vuOUDC3vmRKqq8NOGWBk7DvpFHGEWTtY0TlHHR0Eq7yRH6Djre5yNczgbP1IdaO3vtc6Gq9fboK_0Yt4r1XbihphFTh8EkjxbgW56NlnC9NkAsRV1kzIvsYt1QZKtlCbYs4Jxt0zlOhNb_p1b5Xy5V97O8JzURXQbAHZLEDfxlUKNa7_Cz4CugCjIg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2479747783</pqid></control><display><type>article</type><title>Post-stroke cognitive impairment on the Mini-Mental State Examination primarily relates to left middle cerebral artery infarcts</title><source>SAGE Complete</source><creator>Weaver, Nick A ; Kancheva, Angelina K ; Lim, Jae-Sung ; Biesbroek, J Matthijs ; Wajer, Irene MC Huenges ; Kang, Yeonwook ; Kim, Beom J ; Kuijf, Hugo J ; Lee, Byung-Chul ; Lee, Keon-Joo ; Yu, Kyung-Ho ; Biessels, Geert Jan ; Bae, Hee-Joon</creator><creatorcontrib>Weaver, Nick A ; Kancheva, Angelina K ; Lim, Jae-Sung ; Biesbroek, J Matthijs ; Wajer, Irene MC Huenges ; Kang, Yeonwook ; Kim, Beom J ; Kuijf, Hugo J ; Lee, Byung-Chul ; Lee, Keon-Joo ; Yu, Kyung-Ho ; Biessels, Geert Jan ; Bae, Hee-Joon</creatorcontrib><description>Background Post-stroke cognitive impairment can occur after damage to various brain regions, and cognitive deficits depend on infarct location. The Mini-Mental State Examination (MMSE) is still widely used to assess post-stroke cognition, but it has been criticized for capturing only certain cognitive deficits. Along these lines, it might be hypothesized that cognitive deficits as measured with the MMSE primarily involve certain infarct locations. Aims This comprehensive lesion-symptom mapping study aimed to determine which acute infarct locations are associated with post-stroke cognitive impairment on the MMSE. Methods We examined associations between impairment on the MMSE (&lt;5th percentile; normative data) and infarct location in 1198 patients (age 67 ± 12 years, 43% female) with acute ischemic stroke using voxel-based lesion-symptom mapping. As a frame of reference, infarct patterns associated with impairments in individual cognitive domains were determined, based on a more detailed neuropsychological assessment. Results Impairment on the MMSE was present in 420 patients (35%). Large voxel clusters in the left middle cerebral artery territory and thalamus were significantly (p &lt; 0.01) associated with cognitive impairment on the MMSE, with highest odds ratios (&gt;15) in the thalamus and superior temporal gyrus. In comparison, domain-specific impairments were related to various infarct patterns across both hemispheres including the left medial temporal lobe (verbal memory) and right parietal lobe (visuospatial functioning). Conclusions Our findings indicate that post-stroke cognitive impairment on the MMSE primarily relates to infarct locations in the left middle cerebral artery territory. The MMSE is apparently less sensitive to cognitive deficits that specifically relate to other locations.</description><identifier>ISSN: 1747-4930</identifier><identifier>EISSN: 1747-4949</identifier><identifier>DOI: 10.1177/1747493020984552</identifier><identifier>PMID: 33472574</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><ispartof>International journal of stroke, 2021-10, Vol.16 (8), p.981-989</ispartof><rights>2021 World Stroke Organization</rights><rights>2021 World Stroke Organization 2021 World Stroke Organization</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-27c182a5384dd96310b53928486a5368ae20f967d80d02ccbc46dd1d1b4282af3</citedby><cites>FETCH-LOGICAL-c434t-27c182a5384dd96310b53928486a5368ae20f967d80d02ccbc46dd1d1b4282af3</cites><orcidid>0000-0001-8425-8436 ; 0000-0001-7017-2148</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1747493020984552$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1747493020984552$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33472574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weaver, Nick A</creatorcontrib><creatorcontrib>Kancheva, Angelina K</creatorcontrib><creatorcontrib>Lim, Jae-Sung</creatorcontrib><creatorcontrib>Biesbroek, J Matthijs</creatorcontrib><creatorcontrib>Wajer, Irene MC Huenges</creatorcontrib><creatorcontrib>Kang, Yeonwook</creatorcontrib><creatorcontrib>Kim, Beom J</creatorcontrib><creatorcontrib>Kuijf, Hugo J</creatorcontrib><creatorcontrib>Lee, Byung-Chul</creatorcontrib><creatorcontrib>Lee, Keon-Joo</creatorcontrib><creatorcontrib>Yu, Kyung-Ho</creatorcontrib><creatorcontrib>Biessels, Geert Jan</creatorcontrib><creatorcontrib>Bae, Hee-Joon</creatorcontrib><title>Post-stroke cognitive impairment on the Mini-Mental State Examination primarily relates to left middle cerebral artery infarcts</title><title>International journal of stroke</title><addtitle>Int J Stroke</addtitle><description>Background Post-stroke cognitive impairment can occur after damage to various brain regions, and cognitive deficits depend on infarct location. The Mini-Mental State Examination (MMSE) is still widely used to assess post-stroke cognition, but it has been criticized for capturing only certain cognitive deficits. Along these lines, it might be hypothesized that cognitive deficits as measured with the MMSE primarily involve certain infarct locations. Aims This comprehensive lesion-symptom mapping study aimed to determine which acute infarct locations are associated with post-stroke cognitive impairment on the MMSE. Methods We examined associations between impairment on the MMSE (&lt;5th percentile; normative data) and infarct location in 1198 patients (age 67 ± 12 years, 43% female) with acute ischemic stroke using voxel-based lesion-symptom mapping. As a frame of reference, infarct patterns associated with impairments in individual cognitive domains were determined, based on a more detailed neuropsychological assessment. Results Impairment on the MMSE was present in 420 patients (35%). Large voxel clusters in the left middle cerebral artery territory and thalamus were significantly (p &lt; 0.01) associated with cognitive impairment on the MMSE, with highest odds ratios (&gt;15) in the thalamus and superior temporal gyrus. In comparison, domain-specific impairments were related to various infarct patterns across both hemispheres including the left medial temporal lobe (verbal memory) and right parietal lobe (visuospatial functioning). Conclusions Our findings indicate that post-stroke cognitive impairment on the MMSE primarily relates to infarct locations in the left middle cerebral artery territory. The MMSE is apparently less sensitive to cognitive deficits that specifically relate to other locations.</description><issn>1747-4930</issn><issn>1747-4949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><recordid>eNp1UU1P3DAUtKpWhdLee6p85JLir8TOBQkh-iGBqAQ9W479spgm9mJ7EXvqX8erhVVB6snWezPj8QxCnyn5SqmUR1QKKXpOGOmVaFv2Bu1vRo3oRf92d-dkD33I-ZYQ0UrevUd7nAvJWin20d9fMZcmlxT_ALZxEXzx94D9vDQ-zRAKjgGXG8AXPvjmog7MhK-KKYDPHszsgym-IpbJzyb5aY0TTHWZcYl4grHg2Ts3VWlIMKTKNalAWmMfRpNsyR_Ru9FMGT49nQfo97ez69Mfzfnl95-nJ-eNFVyUhklLFTMtV8K5vuOUDC3vmRKqq8NOGWBk7DvpFHGEWTtY0TlHHR0Eq7yRH6Djre5yNczgbP1IdaO3vtc6Gq9fboK_0Yt4r1XbihphFTh8EkjxbgW56NlnC9NkAsRV1kzIvsYt1QZKtlCbYs4Jxt0zlOhNb_p1b5Xy5V97O8JzURXQbAHZLEDfxlUKNa7_Cz4CugCjIg</recordid><startdate>20211001</startdate><enddate>20211001</enddate><creator>Weaver, Nick A</creator><creator>Kancheva, Angelina K</creator><creator>Lim, Jae-Sung</creator><creator>Biesbroek, J Matthijs</creator><creator>Wajer, Irene MC Huenges</creator><creator>Kang, Yeonwook</creator><creator>Kim, Beom J</creator><creator>Kuijf, Hugo J</creator><creator>Lee, Byung-Chul</creator><creator>Lee, Keon-Joo</creator><creator>Yu, Kyung-Ho</creator><creator>Biessels, Geert Jan</creator><creator>Bae, Hee-Joon</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8425-8436</orcidid><orcidid>https://orcid.org/0000-0001-7017-2148</orcidid></search><sort><creationdate>20211001</creationdate><title>Post-stroke cognitive impairment on the Mini-Mental State Examination primarily relates to left middle cerebral artery infarcts</title><author>Weaver, Nick A ; Kancheva, Angelina K ; Lim, Jae-Sung ; Biesbroek, J Matthijs ; Wajer, Irene MC Huenges ; Kang, Yeonwook ; Kim, Beom J ; Kuijf, Hugo J ; Lee, Byung-Chul ; Lee, Keon-Joo ; Yu, Kyung-Ho ; Biessels, Geert Jan ; Bae, Hee-Joon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-27c182a5384dd96310b53928486a5368ae20f967d80d02ccbc46dd1d1b4282af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weaver, Nick A</creatorcontrib><creatorcontrib>Kancheva, Angelina K</creatorcontrib><creatorcontrib>Lim, Jae-Sung</creatorcontrib><creatorcontrib>Biesbroek, J Matthijs</creatorcontrib><creatorcontrib>Wajer, Irene MC Huenges</creatorcontrib><creatorcontrib>Kang, Yeonwook</creatorcontrib><creatorcontrib>Kim, Beom J</creatorcontrib><creatorcontrib>Kuijf, Hugo J</creatorcontrib><creatorcontrib>Lee, Byung-Chul</creatorcontrib><creatorcontrib>Lee, Keon-Joo</creatorcontrib><creatorcontrib>Yu, Kyung-Ho</creatorcontrib><creatorcontrib>Biessels, Geert Jan</creatorcontrib><creatorcontrib>Bae, Hee-Joon</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of stroke</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weaver, Nick A</au><au>Kancheva, Angelina K</au><au>Lim, Jae-Sung</au><au>Biesbroek, J Matthijs</au><au>Wajer, Irene MC Huenges</au><au>Kang, Yeonwook</au><au>Kim, Beom J</au><au>Kuijf, Hugo J</au><au>Lee, Byung-Chul</au><au>Lee, Keon-Joo</au><au>Yu, Kyung-Ho</au><au>Biessels, Geert Jan</au><au>Bae, Hee-Joon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post-stroke cognitive impairment on the Mini-Mental State Examination primarily relates to left middle cerebral artery infarcts</atitle><jtitle>International journal of stroke</jtitle><addtitle>Int J Stroke</addtitle><date>2021-10-01</date><risdate>2021</risdate><volume>16</volume><issue>8</issue><spage>981</spage><epage>989</epage><pages>981-989</pages><issn>1747-4930</issn><eissn>1747-4949</eissn><abstract>Background Post-stroke cognitive impairment can occur after damage to various brain regions, and cognitive deficits depend on infarct location. The Mini-Mental State Examination (MMSE) is still widely used to assess post-stroke cognition, but it has been criticized for capturing only certain cognitive deficits. Along these lines, it might be hypothesized that cognitive deficits as measured with the MMSE primarily involve certain infarct locations. Aims This comprehensive lesion-symptom mapping study aimed to determine which acute infarct locations are associated with post-stroke cognitive impairment on the MMSE. Methods We examined associations between impairment on the MMSE (&lt;5th percentile; normative data) and infarct location in 1198 patients (age 67 ± 12 years, 43% female) with acute ischemic stroke using voxel-based lesion-symptom mapping. As a frame of reference, infarct patterns associated with impairments in individual cognitive domains were determined, based on a more detailed neuropsychological assessment. Results Impairment on the MMSE was present in 420 patients (35%). Large voxel clusters in the left middle cerebral artery territory and thalamus were significantly (p &lt; 0.01) associated with cognitive impairment on the MMSE, with highest odds ratios (&gt;15) in the thalamus and superior temporal gyrus. In comparison, domain-specific impairments were related to various infarct patterns across both hemispheres including the left medial temporal lobe (verbal memory) and right parietal lobe (visuospatial functioning). Conclusions Our findings indicate that post-stroke cognitive impairment on the MMSE primarily relates to infarct locations in the left middle cerebral artery territory. The MMSE is apparently less sensitive to cognitive deficits that specifically relate to other locations.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>33472574</pmid><doi>10.1177/1747493020984552</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8425-8436</orcidid><orcidid>https://orcid.org/0000-0001-7017-2148</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1747-4930
ispartof International journal of stroke, 2021-10, Vol.16 (8), p.981-989
issn 1747-4930
1747-4949
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8554493
source SAGE Complete
title Post-stroke cognitive impairment on the Mini-Mental State Examination primarily relates to left middle cerebral artery infarcts
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T12%3A34%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Post-stroke%20cognitive%20impairment%20on%20the%20Mini-Mental%20State%20Examination%20primarily%20relates%20to%20left%20middle%20cerebral%20artery%20infarcts&rft.jtitle=International%20journal%20of%20stroke&rft.au=Weaver,%20Nick%20A&rft.date=2021-10-01&rft.volume=16&rft.issue=8&rft.spage=981&rft.epage=989&rft.pages=981-989&rft.issn=1747-4930&rft.eissn=1747-4949&rft_id=info:doi/10.1177/1747493020984552&rft_dat=%3Cproquest_pubme%3E2479747783%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2479747783&rft_id=info:pmid/33472574&rft_sage_id=10.1177_1747493020984552&rfr_iscdi=true