Seasonal coronavirus-specific B cells with limited SARS-CoV-2 cross-reactivity dominate the IgG response in severe COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19). Little is known about the interplay between preexisting immunity to endemic seasonal coronaviruses and the development of a SARS-CoV-2-specific IgG response. We investigated the kinetics...

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Veröffentlicht in:The Journal of clinical investigation 2021-11, Vol.131 (21), p.1-13
Hauptverfasser: Aguilar-Bretones, Muriel, Westerhuis, Brenda M, Raadsen, Matthijs P, de Bruin, Erwin, Chandler, Felicity D, Okba, Nisreen Ma, Haagmans, Bart L, Langerak, Thomas, Endeman, Henrik, van den Akker, Johannes Pc, Gommers, Diederik Ampj, van Gorp, Eric Cm, GeurtsvanKessel, Corine H, de Vries, Rory D, Fouchier, Ron Am, Rockx, Barry Hg, Koopmans, Marion Pg, van Nierop, Gijsbert P
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Sprache:eng
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