FGFR1 Signaling Stimulates Proliferation of Human Mesenchymal Stem Cells by Inhibiting the Cyclin‐Dependent Kinase Inhibitors p21Waf1 and p27Kip1

Signaling through fibroblast growth factor receptor one (FGFR1) is a known inducer of proliferation in both embryonic and human adult mesenchymal stem cells (hMSCs) and positively regulates maintenance of stem cell viability. Leveraging the mitogenic potential of FGF2/FGFR1 signaling in stem cells f...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2013-12, Vol.31 (12), p.2724-2736
Hauptverfasser:	Dombrowski, Christian, Helledie, Torben, Ling, Ling, Grünert, Martin, Canning, Claire A., Jones, C. Michael, Hui, James H., Nurcombe, Victor, van Wijnen, Andre J., Cool, Simon M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult stem cells Bone marrow Cell cycle Cell expansion Cyclin-dependent kinases Fibroblast growth factor Heparin‐binding Kinases Stem cells
Online-Zugang:	Volltext
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