A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome

Older patients with severe physical trauma are at high risk of developing neuropsychiatric syndromes with global impairment of cognition, attention, and consciousness. We employed a thoracic trauma (TxT) mouse model and thoroughly analyzed age-dependent spatial and temporal posttraumatic alterations...

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Veröffentlicht in:	Molecular psychiatry 2021-08, Vol.26 (8), p.3778-3794
Hauptverfasser:	Cursano, Silvia, Battaglia, Chiara R., Urrutia-Ruiz, Carolina, Grabrucker, Stefanie, Schön, Michael, Bockmann, Jürgen, Braumüller, Sonja, Radermacher, Peter, Roselli, Francesco, Huber-Lang, Markus, Boeckers, Tobias M.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/105 13/51 14/28 631/378 631/477 64/60 692/699/476/1414 82/79 Age Animals Antipsychotic drugs Autophagy Behavioral Sciences Biological Psychology Brain-derived neurotrophic factor Central nervous system Clinical trials Cognition Complications and side effects Corticotropin releasing hormone Delirium Development and progression Dosage and administration Drug therapy Health aspects Hippocampus Hippocampus (Brain) Hormone receptors Humans Lysosomes Medicine Medicine & Public Health Memory Memory Disorders - drug therapy Memory Disorders - etiology Memory, Disorders of Mice Motor activity Neurons Neurosciences NF-κB protein Phagocytosis Pharmacotherapy Physiological aspects Prevention Psychiatry Pyramidal cells Receptors, Corticotropin-Releasing Hormone Risk factors Synapses Syndrome Thorax Trauma Wounds and injuries
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