Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population
Alcohol use and smoking are leading causes of death and disability worldwide. Both genetic and environmental factors have been shown to influence individual differences in the use of these substances. In the present study we tested whether genetic factors, modelled alongside common family environmen...
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| Veröffentlicht in: | Molecular psychiatry 2021-08, Vol.26 (8), p.4344-4354 |
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| creator | Clarke, Toni-Kim Adams, Mark J. Howard, David M. Xia, Charley Davies, Gail Hayward, Caroline Campbell, Archie Padmanabhan, Sandosh Smith, Blair H. Murray, Alison Porteous, David Deary, Ian J. McIntosh, Andrew M. |
| description | Alcohol use and smoking are leading causes of death and disability worldwide. Both genetic and environmental factors have been shown to influence individual differences in the use of these substances. In the present study we tested whether genetic factors, modelled alongside common family environment, explained phenotypic variance in alcohol use and smoking behaviour in the Generation Scotland (GS) family sample of up to 19,377 individuals. SNP and pedigree-associated effects combined explained between 18 and 41% of the variance in substance use. Shared couple effects explained a significant amount of variance across all substance use traits, particularly alcohol intake, for which 38% of the phenotypic variance was explained. We tested whether the within-couple substance use associations were due to assortative mating by testing the association between partner polygenic risk scores in 34,987 couple pairs from the UK Biobank (UKB). No significant association between partner polygenic risk scores were observed. Associations between an individual's alcohol PRS (
b
= 0.05, S.E. = 0.006,
p
|
| doi_str_mv | 10.1038/s41380-019-0607-x |
| format | Article |
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b
= 0.05, S.E. = 0.006,
p
< 2 × 10
−16
) and smoking status PRS (
b
= 0.05, S.E. = 0.005,
p
< 2 × 10
−16
) were found with their partner’s phenotype. In support of this, G carriers of a functional
ADH1B
polymorphism (rs1229984), known to be associated with greater alcohol intake, were found to consume less alcohol if they had a partner who carried an A allele at this SNP. Together these results show that the shared couple environment contributes significantly to patterns of substance use. It is unclear whether this is due to shared environmental factors, assortative mating, or indirect genetic effects. Future studies would benefit from longitudinal data and larger sample sizes to assess this further.</description><identifier>ISSN: 1359-4184</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/s41380-019-0607-x</identifier><identifier>PMID: 31767999</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>45/43 ; 631/208 ; 692/699/476/5 ; Alcohol dehydrogenase ; Alcohol Dehydrogenase - genetics ; Alcohol Drinking - genetics ; Alcohol use ; Assortative mating ; Behavior ; Behavioral Sciences ; Biological Psychology ; Couples ; Drinking of alcoholic beverages ; Drug use ; Environmental factors ; Family ; Genetic aspects ; Genetic factors ; Humans ; Medicine ; Medicine & Public Health ; Neurosciences ; Pedigree ; Pharmacotherapy ; Phenotypes ; Phenotypic variations ; Polygenic inheritance ; Psychiatry ; Scotland ; Single-nucleotide polymorphism ; Smoking ; Smoking - genetics ; Social aspects ; Substance use ; Tobacco Smoking</subject><ispartof>Molecular psychiatry, 2021-08, Vol.26 (8), p.4344-4354</ispartof><rights>The Author(s) 2019</rights><rights>2019. The Author(s).</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-661295dd99a6227faade3f2c48605e11b2e1e7a07126732196569d3e337a2c423</citedby><cites>FETCH-LOGICAL-c537t-661295dd99a6227faade3f2c48605e11b2e1e7a07126732196569d3e337a2c423</cites><orcidid>0000-0002-6005-1972 ; 0000-0002-5362-9430 ; 0000-0002-0198-4588 ; 0000-0002-9405-9550 ; 0000-0002-3599-6018 ; 0000-0003-1249-6106</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41380-019-0607-x$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41380-019-0607-x$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31767999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Clarke, Toni-Kim</creatorcontrib><creatorcontrib>Adams, Mark J.</creatorcontrib><creatorcontrib>Howard, David M.</creatorcontrib><creatorcontrib>Xia, Charley</creatorcontrib><creatorcontrib>Davies, Gail</creatorcontrib><creatorcontrib>Hayward, Caroline</creatorcontrib><creatorcontrib>Campbell, Archie</creatorcontrib><creatorcontrib>Padmanabhan, Sandosh</creatorcontrib><creatorcontrib>Smith, Blair H.</creatorcontrib><creatorcontrib>Murray, Alison</creatorcontrib><creatorcontrib>Porteous, David</creatorcontrib><creatorcontrib>Deary, Ian J.</creatorcontrib><creatorcontrib>McIntosh, Andrew M.</creatorcontrib><title>Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Alcohol use and smoking are leading causes of death and disability worldwide. Both genetic and environmental factors have been shown to influence individual differences in the use of these substances. In the present study we tested whether genetic factors, modelled alongside common family environment, explained phenotypic variance in alcohol use and smoking behaviour in the Generation Scotland (GS) family sample of up to 19,377 individuals. SNP and pedigree-associated effects combined explained between 18 and 41% of the variance in substance use. Shared couple effects explained a significant amount of variance across all substance use traits, particularly alcohol intake, for which 38% of the phenotypic variance was explained. We tested whether the within-couple substance use associations were due to assortative mating by testing the association between partner polygenic risk scores in 34,987 couple pairs from the UK Biobank (UKB). No significant association between partner polygenic risk scores were observed. Associations between an individual's alcohol PRS (
b
= 0.05, S.E. = 0.006,
p
< 2 × 10
−16
) and smoking status PRS (
b
= 0.05, S.E. = 0.005,
p
< 2 × 10
−16
) were found with their partner’s phenotype. In support of this, G carriers of a functional
ADH1B
polymorphism (rs1229984), known to be associated with greater alcohol intake, were found to consume less alcohol if they had a partner who carried an A allele at this SNP. Together these results show that the shared couple environment contributes significantly to patterns of substance use. It is unclear whether this is due to shared environmental factors, assortative mating, or indirect genetic effects. Future studies would benefit from longitudinal data and larger sample sizes to assess this further.</description><subject>45/43</subject><subject>631/208</subject><subject>692/699/476/5</subject><subject>Alcohol dehydrogenase</subject><subject>Alcohol Dehydrogenase - genetics</subject><subject>Alcohol Drinking - genetics</subject><subject>Alcohol use</subject><subject>Assortative mating</subject><subject>Behavior</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Couples</subject><subject>Drinking of alcoholic beverages</subject><subject>Drug use</subject><subject>Environmental factors</subject><subject>Family</subject><subject>Genetic aspects</subject><subject>Genetic factors</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosciences</subject><subject>Pedigree</subject><subject>Pharmacotherapy</subject><subject>Phenotypes</subject><subject>Phenotypic variations</subject><subject>Polygenic inheritance</subject><subject>Psychiatry</subject><subject>Scotland</subject><subject>Single-nucleotide polymorphism</subject><subject>Smoking</subject><subject>Smoking - 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Both genetic and environmental factors have been shown to influence individual differences in the use of these substances. In the present study we tested whether genetic factors, modelled alongside common family environment, explained phenotypic variance in alcohol use and smoking behaviour in the Generation Scotland (GS) family sample of up to 19,377 individuals. SNP and pedigree-associated effects combined explained between 18 and 41% of the variance in substance use. Shared couple effects explained a significant amount of variance across all substance use traits, particularly alcohol intake, for which 38% of the phenotypic variance was explained. We tested whether the within-couple substance use associations were due to assortative mating by testing the association between partner polygenic risk scores in 34,987 couple pairs from the UK Biobank (UKB). No significant association between partner polygenic risk scores were observed. Associations between an individual's alcohol PRS (
b
= 0.05, S.E. = 0.006,
p
< 2 × 10
−16
) and smoking status PRS (
b
= 0.05, S.E. = 0.005,
p
< 2 × 10
−16
) were found with their partner’s phenotype. In support of this, G carriers of a functional
ADH1B
polymorphism (rs1229984), known to be associated with greater alcohol intake, were found to consume less alcohol if they had a partner who carried an A allele at this SNP. Together these results show that the shared couple environment contributes significantly to patterns of substance use. It is unclear whether this is due to shared environmental factors, assortative mating, or indirect genetic effects. Future studies would benefit from longitudinal data and larger sample sizes to assess this further.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31767999</pmid><doi>10.1038/s41380-019-0607-x</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6005-1972</orcidid><orcidid>https://orcid.org/0000-0002-5362-9430</orcidid><orcidid>https://orcid.org/0000-0002-0198-4588</orcidid><orcidid>https://orcid.org/0000-0002-9405-9550</orcidid><orcidid>https://orcid.org/0000-0002-3599-6018</orcidid><orcidid>https://orcid.org/0000-0003-1249-6106</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1359-4184 |
| ispartof | Molecular psychiatry, 2021-08, Vol.26 (8), p.4344-4354 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8550945 |
| source | MEDLINE; Springer Journals |
| subjects | 45/43 631/208 692/699/476/5 Alcohol dehydrogenase Alcohol Dehydrogenase - genetics Alcohol Drinking - genetics Alcohol use Assortative mating Behavior Behavioral Sciences Biological Psychology Couples Drinking of alcoholic beverages Drug use Environmental factors Family Genetic aspects Genetic factors Humans Medicine Medicine & Public Health Neurosciences Pedigree Pharmacotherapy Phenotypes Phenotypic variations Polygenic inheritance Psychiatry Scotland Single-nucleotide polymorphism Smoking Smoking - genetics Social aspects Substance use Tobacco Smoking |
| title | Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population |
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