Excessive daytime sleepiness in sleep apnea: any role of testosterone or vitamin D?
Recent studies reported association of sleep-disordered breathing (SDB) with testosterone and vitamin D deficiency. Low testosterone and vitamin D levels have been linked to fatigue and excessive daytime sleepiness (EDS). However, the impact of testosterone and vitamin D deficiency on EDS in subject...
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| Veröffentlicht in: | Physiological research 2020-11, Vol.69 (5), p.907-917 |
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| description | Recent studies reported association of sleep-disordered breathing (SDB) with testosterone and vitamin D deficiency. Low testosterone and vitamin D levels have been linked to fatigue and excessive daytime sleepiness (EDS). However, the impact of testosterone and vitamin D deficiency on EDS in subjects with SDB remains unknown. The aim of this study was to explore the predictors of EDS in habitual snorers. Role of testosterone, and vitamin D was studied in detail. We also looked for associations between testosterone, vitamin D, and sleep-related indices. We prospectively enrolled 291 consecutive male patients with habitual snoring. Baseline clinical characteristics were recorded on admission. Standard overnight polysomnography was performed to detect SDB, and Epworth Sleepiness Scale (ESS) was used to assess EDS. Blood samples were obtained in a fasting condition in the morning after polysomnography to determine levels of testosterone and vitamin D. Respiratory disturbance index (RDI) (95 % CI: 1.004-1.024, p=0.005) and the use of antihistamines (95 % CI: 1.083-11.901, p=0.037) were the only independent variables significantly associated with EDS in binary logistic regression analysis. In linear multiple regression analysis, body mass index (BMI) (Beta=-0.282, p |
| doi_str_mv | 10.33549/physiolres.934507 |
| format | Article |
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Low testosterone and vitamin D levels have been linked to fatigue and excessive daytime sleepiness (EDS). However, the impact of testosterone and vitamin D deficiency on EDS in subjects with SDB remains unknown. The aim of this study was to explore the predictors of EDS in habitual snorers. Role of testosterone, and vitamin D was studied in detail. We also looked for associations between testosterone, vitamin D, and sleep-related indices. We prospectively enrolled 291 consecutive male patients with habitual snoring. Baseline clinical characteristics were recorded on admission. Standard overnight polysomnography was performed to detect SDB, and Epworth Sleepiness Scale (ESS) was used to assess EDS. Blood samples were obtained in a fasting condition in the morning after polysomnography to determine levels of testosterone and vitamin D. Respiratory disturbance index (RDI) (95 % CI: 1.004-1.024, p=0.005) and the use of antihistamines (95 % CI: 1.083-11.901, p=0.037) were the only independent variables significantly associated with EDS in binary logistic regression analysis. In linear multiple regression analysis, body mass index (BMI) (Beta=-0.282, p<0.001) and oxygen desaturation index (Beta=-0.150, p=0.043) were the only independent variables significantly associated with testosterone levels, and BMI (Beta=-0.142, p=0.016) was the only independent variable significantly associated with vitamin D. We failed to find any independent association of testosterone and vitamin D with subjectively rated EDS among habitual snorers. Our results suggest an independent association between the magnitude of nocturnal desaturation and testosterone levels.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.934507</identifier><identifier>PMID: 32901503</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Antihistamines ; Apnea ; Body Mass Index ; Cardiovascular disease ; Comorbidity ; Daytime ; Disorders of Excessive Somnolence - blood ; Disorders of Excessive Somnolence - pathology ; Fatigue ; Histamine ; Humans ; Immunoassay ; Laboratories ; Male ; Males ; Middle Aged ; Multiple regression analysis ; Polysomnography - methods ; Prospective Studies ; Regression analysis ; Restless legs syndrome ; Sleep ; Sleep and wakefulness ; Sleep apnea ; Sleep Apnea, Obstructive - blood ; Sleep Apnea, Obstructive - pathology ; Sleep deprivation ; Sleep disorders ; Testosterone ; Testosterone - blood ; United Kingdom - epidemiology ; Variables ; Vitamin D ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - pathology ; Vitamin deficiency ; Vitamins - blood</subject><ispartof>Physiological research, 2020-11, Vol.69 (5), p.907-917</ispartof><rights>Copyright Institute of Physiology 2020</rights><rights>2020 Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-8fc5961538dc4abe13fdfee2b9de3af32479cadf1fd518f6467692f0ff79c6403</citedby><cites>FETCH-LOGICAL-c397t-8fc5961538dc4abe13fdfee2b9de3af32479cadf1fd518f6467692f0ff79c6403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549906/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8549906/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32901503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Šiarnik, P</creatorcontrib><creatorcontrib>Jurík, M</creatorcontrib><creatorcontrib>Hardoňová, M</creatorcontrib><creatorcontrib>Klobučníková, K</creatorcontrib><creatorcontrib>Veverka, J</creatorcontrib><creatorcontrib>Šurda, P</creatorcontrib><creatorcontrib>Turčáni, P</creatorcontrib><creatorcontrib>Kollár, B</creatorcontrib><title>Excessive daytime sleepiness in sleep apnea: any role of testosterone or vitamin D?</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>Recent studies reported association of sleep-disordered breathing (SDB) with testosterone and vitamin D deficiency. Low testosterone and vitamin D levels have been linked to fatigue and excessive daytime sleepiness (EDS). However, the impact of testosterone and vitamin D deficiency on EDS in subjects with SDB remains unknown. The aim of this study was to explore the predictors of EDS in habitual snorers. Role of testosterone, and vitamin D was studied in detail. We also looked for associations between testosterone, vitamin D, and sleep-related indices. We prospectively enrolled 291 consecutive male patients with habitual snoring. Baseline clinical characteristics were recorded on admission. Standard overnight polysomnography was performed to detect SDB, and Epworth Sleepiness Scale (ESS) was used to assess EDS. Blood samples were obtained in a fasting condition in the morning after polysomnography to determine levels of testosterone and vitamin D. Respiratory disturbance index (RDI) (95 % CI: 1.004-1.024, p=0.005) and the use of antihistamines (95 % CI: 1.083-11.901, p=0.037) were the only independent variables significantly associated with EDS in binary logistic regression analysis. In linear multiple regression analysis, body mass index (BMI) (Beta=-0.282, p<0.001) and oxygen desaturation index (Beta=-0.150, p=0.043) were the only independent variables significantly associated with testosterone levels, and BMI (Beta=-0.142, p=0.016) was the only independent variable significantly associated with vitamin D. We failed to find any independent association of testosterone and vitamin D with subjectively rated EDS among habitual snorers. Our results suggest an independent association between the magnitude of nocturnal desaturation and testosterone levels.</description><subject>Antihistamines</subject><subject>Apnea</subject><subject>Body Mass Index</subject><subject>Cardiovascular disease</subject><subject>Comorbidity</subject><subject>Daytime</subject><subject>Disorders of Excessive Somnolence - blood</subject><subject>Disorders of Excessive Somnolence - pathology</subject><subject>Fatigue</subject><subject>Histamine</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Laboratories</subject><subject>Male</subject><subject>Males</subject><subject>Middle Aged</subject><subject>Multiple regression analysis</subject><subject>Polysomnography - methods</subject><subject>Prospective Studies</subject><subject>Regression analysis</subject><subject>Restless legs syndrome</subject><subject>Sleep</subject><subject>Sleep and wakefulness</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - 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blood</topic><topic>Disorders of Excessive Somnolence - pathology</topic><topic>Fatigue</topic><topic>Histamine</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Laboratories</topic><topic>Male</topic><topic>Males</topic><topic>Middle Aged</topic><topic>Multiple regression analysis</topic><topic>Polysomnography - methods</topic><topic>Prospective Studies</topic><topic>Regression analysis</topic><topic>Restless legs syndrome</topic><topic>Sleep</topic><topic>Sleep and wakefulness</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - blood</topic><topic>Sleep Apnea, Obstructive - pathology</topic><topic>Sleep deprivation</topic><topic>Sleep disorders</topic><topic>Testosterone</topic><topic>Testosterone - blood</topic><topic>United Kingdom - epidemiology</topic><topic>Variables</topic><topic>Vitamin D</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - pathology</topic><topic>Vitamin deficiency</topic><topic>Vitamins - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Šiarnik, P</creatorcontrib><creatorcontrib>Jurík, M</creatorcontrib><creatorcontrib>Hardoňová, M</creatorcontrib><creatorcontrib>Klobučníková, K</creatorcontrib><creatorcontrib>Veverka, J</creatorcontrib><creatorcontrib>Šurda, P</creatorcontrib><creatorcontrib>Turčáni, P</creatorcontrib><creatorcontrib>Kollár, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Physiological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Šiarnik, P</au><au>Jurík, M</au><au>Hardoňová, M</au><au>Klobučníková, K</au><au>Veverka, J</au><au>Šurda, P</au><au>Turčáni, P</au><au>Kollár, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Excessive daytime sleepiness in sleep apnea: any role of testosterone or vitamin D?</atitle><jtitle>Physiological research</jtitle><addtitle>Physiol Res</addtitle><date>2020-11-16</date><risdate>2020</risdate><volume>69</volume><issue>5</issue><spage>907</spage><epage>917</epage><pages>907-917</pages><issn>0862-8408</issn><eissn>1802-9973</eissn><abstract>Recent studies reported association of sleep-disordered breathing (SDB) with testosterone and vitamin D deficiency. Low testosterone and vitamin D levels have been linked to fatigue and excessive daytime sleepiness (EDS). However, the impact of testosterone and vitamin D deficiency on EDS in subjects with SDB remains unknown. The aim of this study was to explore the predictors of EDS in habitual snorers. Role of testosterone, and vitamin D was studied in detail. We also looked for associations between testosterone, vitamin D, and sleep-related indices. We prospectively enrolled 291 consecutive male patients with habitual snoring. Baseline clinical characteristics were recorded on admission. Standard overnight polysomnography was performed to detect SDB, and Epworth Sleepiness Scale (ESS) was used to assess EDS. Blood samples were obtained in a fasting condition in the morning after polysomnography to determine levels of testosterone and vitamin D. Respiratory disturbance index (RDI) (95 % CI: 1.004-1.024, p=0.005) and the use of antihistamines (95 % CI: 1.083-11.901, p=0.037) were the only independent variables significantly associated with EDS in binary logistic regression analysis. In linear multiple regression analysis, body mass index (BMI) (Beta=-0.282, p<0.001) and oxygen desaturation index (Beta=-0.150, p=0.043) were the only independent variables significantly associated with testosterone levels, and BMI (Beta=-0.142, p=0.016) was the only independent variable significantly associated with vitamin D. We failed to find any independent association of testosterone and vitamin D with subjectively rated EDS among habitual snorers. Our results suggest an independent association between the magnitude of nocturnal desaturation and testosterone levels.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>32901503</pmid><doi>10.33549/physiolres.934507</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antihistamines Apnea Body Mass Index Cardiovascular disease Comorbidity Daytime Disorders of Excessive Somnolence - blood Disorders of Excessive Somnolence - pathology Fatigue Histamine Humans Immunoassay Laboratories Male Males Middle Aged Multiple regression analysis Polysomnography - methods Prospective Studies Regression analysis Restless legs syndrome Sleep Sleep and wakefulness Sleep apnea Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - pathology Sleep deprivation Sleep disorders Testosterone Testosterone - blood United Kingdom - epidemiology Variables Vitamin D Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - pathology Vitamin deficiency Vitamins - blood |
| title | Excessive daytime sleepiness in sleep apnea: any role of testosterone or vitamin D? |
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