Role of cytochrome c oxidase nuclear-encoded subunits in health and disease

Cytochrome c oxidase (COX), the terminal enzyme of mitochondrial electron transport chain, couples electron transport to oxygen with generation of proton gradient indispensable for the production of vast majority of ATP molecules in mammalian cells. The review summarizes current knowledge of COX str...

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Veröffentlicht in:	Physiological research 2020-11, Vol.69 (6), p.947-965
Hauptverfasser:	Čunátová, K, Reguera, D P, Houštěk, J, Mráček, T, Pecina, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Biosynthesis Cell Nucleus - enzymology Cell Nucleus - genetics Cytochrome Cytochrome-c oxidase Electron transport chain Electron Transport Complex IV - genetics Electron Transport Complex IV - metabolism Enzymatic activity Enzymes Genome Humans Isoforms Mammalian cells Mammals Mitochondria Mitochondria - enzymology Mitochondria - genetics Mitochondrial Diseases - enzymology Mitochondrial Diseases - pathology Mutation Organ Specificity Protein Subunits Proteins Review Signal Transduction Structure-function relationships
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