Botanical Drug Puerarin Ameliorates Liposaccharide-Induced Depressive Behaviors in Mice via Inhibiting RagA/mTOR/p70S6K Pathways

Background. The depressive symptom hallmarks the progression of the neurodegenerative diseases, especially Alzheimer’s disease. Bacterial infection is related to inflammation and depression. The present project thereby examined whether botanical drug puerarin could attenuate liposaccharide- (LPS-) i...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.7716201-7716201
Hauptverfasser:	Zhao, Jia, Jia, Yizhen, Zhao, Wei, Chen, Huixin, Zhang, Xiuying, Ngo, Fung Yin, Luo, Dan, Song, Youqiang, Lao, Lixing, Rong, Jianhui
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Antibodies Antidepressive Agents - pharmacology Autophagy Behavior Behavior, Animal - drug effects Brain - drug effects Brain - enzymology Brain - physiopathology Cytokines Cytokines - metabolism Depression - chemically induced Depression - enzymology Depression - physiopathology Depression - prevention & control Disease Models, Animal Epidermal growth factor Genes Inflammation Mediators - metabolism Isoflavones - pharmacology Kinases Lipopolysaccharides Male Mechanistic Target of Rapamycin Complex 1 - metabolism Mice Mice, Inbred C57BL Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism Neural Stem Cells - drug effects Neural Stem Cells - enzymology Neurons - drug effects Neurons - enzymology PC12 Cells Proteins Rats Ribosomal Protein S6 Kinases, 70-kDa - metabolism Signal Transduction Stem cells TOR Serine-Threonine Kinases - metabolism
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