Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice

Calorie restriction (CR) promotes healthy ageing in diverse species. Recently, it has been shown that fasting for a portion of each day has metabolic benefits and promotes lifespan. These findings complicate the interpretation of rodent CR studies, in which animals typically eat only once per day an...

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Veröffentlicht in:	Nature metabolism 2021-10, Vol.3 (10), p.1327-1341
Hauptverfasser:	Pak, Heidi H., Haws, Spencer A., Green, Cara L., Koller, Mikaela, Lavarias, Mitchell T., Richardson, Nicole E., Yang, Shany E., Dumas, Sabrina N., Sonsalla, Michelle, Bray, Lindsey, Johnson, Michelle, Barnes, Stephen, Darley-Usmar, Victor, Zhang, Jianhua, Yen, Chi-Liang Eric, Denu, John M., Lamming, Dudley W.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 45 45/91 631/443/319/1642 631/443/7 64 64/60 Aging - metabolism Animals Biomedical and Life Sciences Caloric Restriction Life Sciences Longevity - physiology Mice
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