Computational study of effective matrix metalloproteinase 9 (MMP9) targeting natural inhibitors

The present study screened ideal lead natural compounds that could target and inhibit matrix metalloproteinase 9 (MMP9) protein from the ZINC database to develop drugs for clear cell renal cell carcinoma (CCRCC)-targeted treatment. Discovery Studio 4.5 was used to compare and screen the ligands with...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2021-10, Vol.13 (19), p.22867-22882
Hauptverfasser:	Liu, Naimeng, Wang, Xinhui, Wu, Hao, Lv, Xiaye, Xie, Haoqun, Guo, Zhen, Wang, Jing, Dou, Gaojing, Zhang, Chenxi, Sun, Mindan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Biological Products - adverse effects Biological Products - chemistry Biological Products - pharmacology Cell Line, Tumor Drug Delivery Systems Humans Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors - chemistry Matrix Metalloproteinase Inhibitors - pharmacology Models, Molecular Molecular Dynamics Simulation Molecular Structure Protein Conformation Research Paper Structure-Activity Relationship
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