In-vivo evidence of systemic endothelial vascular dysfunction in COVID-19
Endothelial dysfunction is one of the underlying mechanisms to vascular and cardiac complications in patients with COVID-19. We sought to investigate the systemic vascular endothelial function and its temporal changes in COVID-19 patients from a non-invasive approach with reactive hyperemia peripher...
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| Veröffentlicht in: | International journal of cardiology 2021-12, Vol.345, p.153-155 |
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| creator | Mejia-Renteria, Hernan Travieso, Alejandro Sagir, Adam Martínez-Gómez, Eduardo Carrascosa-Granada, Angela Toya, Takumi Núñez-Gil, Iván J. Estrada, Vicente Lerman, Amir Escaned, Javier |
| description | Endothelial dysfunction is one of the underlying mechanisms to vascular and cardiac complications in patients with COVID-19. We sought to investigate the systemic vascular endothelial function and its temporal changes in COVID-19 patients from a non-invasive approach with reactive hyperemia peripheral arterial tonometry (PAT).
This is a prospective, observational, case-control and blinded study. The population was comprised by 3 groups: patients investigated during acute COVID-19 (group 1), patients investigated during past COVID-19 (group 2), and controls 1:1 matched to COVID-19 patients by demographics and cardiovascular risk factors (group 3). The natural logarithmic scaled reactive hyperemia index (LnRHI), a measure of endothelium-mediated dilation of peripheral arteries, was obtained in all the participants and compared between study groups.
144 participants were enrolled (72 COVID-19 patients and 72 matched controls). Median time from COVID-19 symptoms to PAT assessment was 9.5 and 101.5 days in groups 1 and 2, respectively. LnRHI was significantly lower in group 2 compared to both group 1 and controls (0.53 ± 0.23 group 2 vs. 0.72 ± 0.26 group 1, p = 0.0043; and 0.79 ± 0.23 in group 3, p |
| doi_str_mv | 10.1016/j.ijcard.2021.10.140 |
| format | Article |
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This is a prospective, observational, case-control and blinded study. The population was comprised by 3 groups: patients investigated during acute COVID-19 (group 1), patients investigated during past COVID-19 (group 2), and controls 1:1 matched to COVID-19 patients by demographics and cardiovascular risk factors (group 3). The natural logarithmic scaled reactive hyperemia index (LnRHI), a measure of endothelium-mediated dilation of peripheral arteries, was obtained in all the participants and compared between study groups.
144 participants were enrolled (72 COVID-19 patients and 72 matched controls). Median time from COVID-19 symptoms to PAT assessment was 9.5 and 101.5 days in groups 1 and 2, respectively. LnRHI was significantly lower in group 2 compared to both group 1 and controls (0.53 ± 0.23 group 2 vs. 0.72 ± 0.26 group 1, p = 0.0043; and 0.79 ± 0.23 in group 3, p < 0.0001). In addition, within group 1, it was observed a markedly decrease in LnRHI from acute COVID-19 to post infection stage (0.73 ± 0.23 vs. 0.42 ± 0.26, p = 0.0042).
This study suggests a deleterious effect of SARS-CoV-2 infection on systemic vascular endothelial function. These findings open new venues to investigate the clinical implication and prognostic role of vascular endothelial dysfunction in COVID-19 patients and post-COVID syndrome using non-invasive techniques.
•Endothelium-mediated vasodilator function is markedly reduced in COVID-19 post-infection stage compared to active infection and controls.•These findings suggest that endothelial vascular dysfunction may be a chronic complication of the SARS-CoV-2 infection.•This study opens new venues to investigate the clinical implication of vascular endothelial dysfunction in post-COVID syndrome using non-invasive techniques.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2021.10.140</identifier><identifier>PMID: 34706286</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>COVID-19 ; Endothelium, Vascular ; Humans ; Hyperemia ; Manometry ; Prospective Studies ; SARS-CoV-2 ; Short Communication ; Systemic vascular endothelial function ; Vascular Diseases</subject><ispartof>International journal of cardiology, 2021-12, Vol.345, p.153-155</ispartof><rights>2021 Elsevier B.V.</rights><rights>Copyright © 2021 Elsevier B.V. All rights reserved.</rights><rights>2021 Elsevier B.V. All rights reserved. 2021 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-45f2f46709b1cc6d62ce168e0faf0279ca83931c4db364e50749888732e08b7c3</citedby><cites>FETCH-LOGICAL-c463t-45f2f46709b1cc6d62ce168e0faf0279ca83931c4db364e50749888732e08b7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijcard.2021.10.140$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3538,27906,27907,45977</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34706286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mejia-Renteria, Hernan</creatorcontrib><creatorcontrib>Travieso, Alejandro</creatorcontrib><creatorcontrib>Sagir, Adam</creatorcontrib><creatorcontrib>Martínez-Gómez, Eduardo</creatorcontrib><creatorcontrib>Carrascosa-Granada, Angela</creatorcontrib><creatorcontrib>Toya, Takumi</creatorcontrib><creatorcontrib>Núñez-Gil, Iván J.</creatorcontrib><creatorcontrib>Estrada, Vicente</creatorcontrib><creatorcontrib>Lerman, Amir</creatorcontrib><creatorcontrib>Escaned, Javier</creatorcontrib><title>In-vivo evidence of systemic endothelial vascular dysfunction in COVID-19</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Endothelial dysfunction is one of the underlying mechanisms to vascular and cardiac complications in patients with COVID-19. We sought to investigate the systemic vascular endothelial function and its temporal changes in COVID-19 patients from a non-invasive approach with reactive hyperemia peripheral arterial tonometry (PAT).
This is a prospective, observational, case-control and blinded study. The population was comprised by 3 groups: patients investigated during acute COVID-19 (group 1), patients investigated during past COVID-19 (group 2), and controls 1:1 matched to COVID-19 patients by demographics and cardiovascular risk factors (group 3). The natural logarithmic scaled reactive hyperemia index (LnRHI), a measure of endothelium-mediated dilation of peripheral arteries, was obtained in all the participants and compared between study groups.
144 participants were enrolled (72 COVID-19 patients and 72 matched controls). Median time from COVID-19 symptoms to PAT assessment was 9.5 and 101.5 days in groups 1 and 2, respectively. LnRHI was significantly lower in group 2 compared to both group 1 and controls (0.53 ± 0.23 group 2 vs. 0.72 ± 0.26 group 1, p = 0.0043; and 0.79 ± 0.23 in group 3, p < 0.0001). In addition, within group 1, it was observed a markedly decrease in LnRHI from acute COVID-19 to post infection stage (0.73 ± 0.23 vs. 0.42 ± 0.26, p = 0.0042).
This study suggests a deleterious effect of SARS-CoV-2 infection on systemic vascular endothelial function. These findings open new venues to investigate the clinical implication and prognostic role of vascular endothelial dysfunction in COVID-19 patients and post-COVID syndrome using non-invasive techniques.
•Endothelium-mediated vasodilator function is markedly reduced in COVID-19 post-infection stage compared to active infection and controls.•These findings suggest that endothelial vascular dysfunction may be a chronic complication of the SARS-CoV-2 infection.•This study opens new venues to investigate the clinical implication of vascular endothelial dysfunction in post-COVID syndrome using non-invasive techniques.</description><subject>COVID-19</subject><subject>Endothelium, Vascular</subject><subject>Humans</subject><subject>Hyperemia</subject><subject>Manometry</subject><subject>Prospective Studies</subject><subject>SARS-CoV-2</subject><subject>Short Communication</subject><subject>Systemic vascular endothelial function</subject><subject>Vascular Diseases</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UU1v1DAQtRCIbgv_oEI5csnWX7GdCxLaQrtSpV6Aq-UdT6hXWbvYSaT9982ypR8XTiO9efNm5j1CzhldMsrUxXYZtuCyX3LK2fKASvqGLJjRsma6kW_JYqbpuuFanJDTUraUUtm25j05EVJTxY1akPU61lOYUoVT8BgBq9RVZV8G3AWoMPo03GEfXF9NrsDYu1z5fenGCENIsQqxWt3-Wl_WrP1A3nWuL_jxsZ6Rn9-__Vhd1ze3V-vV15sapBJDLZuOd1Jp2m4YgPKKAzJlkHauo1y34IxoBQPpN0JJbKiWrTFGC47UbDSIM_LlqHs_bnboAeOQXW_vc9i5vLfJBfu6E8Od_Z0maxrJRatngc-PAjn9GbEMdhcKYN-7iGksljdG60aJhs9UeaRCTqVk7J7WMGoPKditPaZgDyn8RSWdxz69PPFp6J_tzz_gbNQUMNsC4eC-DxlhsD6F_294ACZemo0</recordid><startdate>20211215</startdate><enddate>20211215</enddate><creator>Mejia-Renteria, Hernan</creator><creator>Travieso, Alejandro</creator><creator>Sagir, Adam</creator><creator>Martínez-Gómez, Eduardo</creator><creator>Carrascosa-Granada, Angela</creator><creator>Toya, Takumi</creator><creator>Núñez-Gil, Iván J.</creator><creator>Estrada, Vicente</creator><creator>Lerman, Amir</creator><creator>Escaned, Javier</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20211215</creationdate><title>In-vivo evidence of systemic endothelial vascular dysfunction in COVID-19</title><author>Mejia-Renteria, Hernan ; Travieso, Alejandro ; Sagir, Adam ; Martínez-Gómez, Eduardo ; Carrascosa-Granada, Angela ; Toya, Takumi ; Núñez-Gil, Iván J. ; Estrada, Vicente ; Lerman, Amir ; Escaned, Javier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-45f2f46709b1cc6d62ce168e0faf0279ca83931c4db364e50749888732e08b7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>COVID-19</topic><topic>Endothelium, Vascular</topic><topic>Humans</topic><topic>Hyperemia</topic><topic>Manometry</topic><topic>Prospective Studies</topic><topic>SARS-CoV-2</topic><topic>Short Communication</topic><topic>Systemic vascular endothelial function</topic><topic>Vascular Diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mejia-Renteria, Hernan</creatorcontrib><creatorcontrib>Travieso, Alejandro</creatorcontrib><creatorcontrib>Sagir, Adam</creatorcontrib><creatorcontrib>Martínez-Gómez, Eduardo</creatorcontrib><creatorcontrib>Carrascosa-Granada, Angela</creatorcontrib><creatorcontrib>Toya, Takumi</creatorcontrib><creatorcontrib>Núñez-Gil, Iván J.</creatorcontrib><creatorcontrib>Estrada, Vicente</creatorcontrib><creatorcontrib>Lerman, Amir</creatorcontrib><creatorcontrib>Escaned, Javier</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mejia-Renteria, Hernan</au><au>Travieso, Alejandro</au><au>Sagir, Adam</au><au>Martínez-Gómez, Eduardo</au><au>Carrascosa-Granada, Angela</au><au>Toya, Takumi</au><au>Núñez-Gil, Iván J.</au><au>Estrada, Vicente</au><au>Lerman, Amir</au><au>Escaned, Javier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In-vivo evidence of systemic endothelial vascular dysfunction in COVID-19</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2021-12-15</date><risdate>2021</risdate><volume>345</volume><spage>153</spage><epage>155</epage><pages>153-155</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><abstract>Endothelial dysfunction is one of the underlying mechanisms to vascular and cardiac complications in patients with COVID-19. We sought to investigate the systemic vascular endothelial function and its temporal changes in COVID-19 patients from a non-invasive approach with reactive hyperemia peripheral arterial tonometry (PAT).
This is a prospective, observational, case-control and blinded study. The population was comprised by 3 groups: patients investigated during acute COVID-19 (group 1), patients investigated during past COVID-19 (group 2), and controls 1:1 matched to COVID-19 patients by demographics and cardiovascular risk factors (group 3). The natural logarithmic scaled reactive hyperemia index (LnRHI), a measure of endothelium-mediated dilation of peripheral arteries, was obtained in all the participants and compared between study groups.
144 participants were enrolled (72 COVID-19 patients and 72 matched controls). Median time from COVID-19 symptoms to PAT assessment was 9.5 and 101.5 days in groups 1 and 2, respectively. LnRHI was significantly lower in group 2 compared to both group 1 and controls (0.53 ± 0.23 group 2 vs. 0.72 ± 0.26 group 1, p = 0.0043; and 0.79 ± 0.23 in group 3, p < 0.0001). In addition, within group 1, it was observed a markedly decrease in LnRHI from acute COVID-19 to post infection stage (0.73 ± 0.23 vs. 0.42 ± 0.26, p = 0.0042).
This study suggests a deleterious effect of SARS-CoV-2 infection on systemic vascular endothelial function. These findings open new venues to investigate the clinical implication and prognostic role of vascular endothelial dysfunction in COVID-19 patients and post-COVID syndrome using non-invasive techniques.
•Endothelium-mediated vasodilator function is markedly reduced in COVID-19 post-infection stage compared to active infection and controls.•These findings suggest that endothelial vascular dysfunction may be a chronic complication of the SARS-CoV-2 infection.•This study opens new venues to investigate the clinical implication of vascular endothelial dysfunction in post-COVID syndrome using non-invasive techniques.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>34706286</pmid><doi>10.1016/j.ijcard.2021.10.140</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | COVID-19 Endothelium, Vascular Humans Hyperemia Manometry Prospective Studies SARS-CoV-2 Short Communication Systemic vascular endothelial function Vascular Diseases |
| title | In-vivo evidence of systemic endothelial vascular dysfunction in COVID-19 |
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