Antimicrobial Natural Products Produced by Soil-Derived Fungus Penicillium cremeogriseum W1-1
Ten compounds ( 1 – 10 ) were obtained from soil-derived Penicillium cremeogriseum W1-1 with the antimicrobial guided isolation procedure. Among them, 4 presented broad-spectrum antimicrobial activities and its preliminary mechanisms were evaluated. Compound 4 showed growth inhibition on drug-resist...
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| Veröffentlicht in: | Indian journal of microbiology 2021-12, Vol.61 (4), p.519-523 |
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| container_title | Indian journal of microbiology |
| container_volume | 61 |
| creator | Sang, Xu-Yan Wang, Zhao-Jie Yang, Ya-Bin Wang, Yong-Liang Xiang, Mei-Ling Zhu, Dou-Ying Zhou, Ying Luo, Xiao-Dong Zhao, Li-Xing |
| description | Ten compounds (
1
–
10
) were obtained from soil-derived
Penicillium cremeogriseum
W1-1 with the antimicrobial guided isolation procedure. Among them,
4
presented broad-spectrum antimicrobial activities and its preliminary mechanisms were evaluated. Compound
4
showed growth inhibition on drug-resistant pathogenic strains
Escherichia coli
and
Candida albicans
with post-contact effect (PCE), changed the morphology and membrane structure, killed cells with leakage, inhibited the growth of
C. albicans
by eradicating biofilms. Interestingly, the fraction containing
4
presented in vivo anti-pathogenic activities in mice, indicating this indole diterpenoid alkaloid could been used as potential antimicrobial agent. |
| doi_str_mv | 10.1007/s12088-021-00957-z |
| format | Article |
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1
–
10
) were obtained from soil-derived
Penicillium cremeogriseum
W1-1 with the antimicrobial guided isolation procedure. Among them,
4
presented broad-spectrum antimicrobial activities and its preliminary mechanisms were evaluated. Compound
4
showed growth inhibition on drug-resistant pathogenic strains
Escherichia coli
and
Candida albicans
with post-contact effect (PCE), changed the morphology and membrane structure, killed cells with leakage, inhibited the growth of
C. albicans
by eradicating biofilms. Interestingly, the fraction containing
4
presented in vivo anti-pathogenic activities in mice, indicating this indole diterpenoid alkaloid could been used as potential antimicrobial agent.</description><identifier>ISSN: 0046-8991</identifier><identifier>EISSN: 0973-7715</identifier><identifier>DOI: 10.1007/s12088-021-00957-z</identifier><identifier>PMID: 34744207</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Antiinfectives and antibacterials ; Antimicrobial agents ; Biofilms ; Biomedical and Life Sciences ; Cytology ; Diterpenes ; Drug resistance ; E coli ; Fungi ; Life Sciences ; Medical Microbiology ; Membrane structure ; Membrane structures ; Microbiology ; Morphology ; Natural products ; Penicillium ; Short Communications ; Soil microorganisms ; Soils</subject><ispartof>Indian journal of microbiology, 2021-12, Vol.61 (4), p.519-523</ispartof><rights>Association of Microbiologists of India 2021</rights><rights>Association of Microbiologists of India 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c402t-424a3d3d90b2baf6d883c6ef7a05b872daa39e3f74f1521b84118e78d67a8a0e3</cites><orcidid>0000-0002-1353-3717</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542016/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8542016/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids></links><search><creatorcontrib>Sang, Xu-Yan</creatorcontrib><creatorcontrib>Wang, Zhao-Jie</creatorcontrib><creatorcontrib>Yang, Ya-Bin</creatorcontrib><creatorcontrib>Wang, Yong-Liang</creatorcontrib><creatorcontrib>Xiang, Mei-Ling</creatorcontrib><creatorcontrib>Zhu, Dou-Ying</creatorcontrib><creatorcontrib>Zhou, Ying</creatorcontrib><creatorcontrib>Luo, Xiao-Dong</creatorcontrib><creatorcontrib>Zhao, Li-Xing</creatorcontrib><title>Antimicrobial Natural Products Produced by Soil-Derived Fungus Penicillium cremeogriseum W1-1</title><title>Indian journal of microbiology</title><addtitle>Indian J Microbiol</addtitle><description>Ten compounds (
1
–
10
) were obtained from soil-derived
Penicillium cremeogriseum
W1-1 with the antimicrobial guided isolation procedure. Among them,
4
presented broad-spectrum antimicrobial activities and its preliminary mechanisms were evaluated. Compound
4
showed growth inhibition on drug-resistant pathogenic strains
Escherichia coli
and
Candida albicans
with post-contact effect (PCE), changed the morphology and membrane structure, killed cells with leakage, inhibited the growth of
C. albicans
by eradicating biofilms. Interestingly, the fraction containing
4
presented in vivo anti-pathogenic activities in mice, indicating this indole diterpenoid alkaloid could been used as potential antimicrobial agent.</description><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Biofilms</subject><subject>Biomedical and Life Sciences</subject><subject>Cytology</subject><subject>Diterpenes</subject><subject>Drug resistance</subject><subject>E coli</subject><subject>Fungi</subject><subject>Life Sciences</subject><subject>Medical Microbiology</subject><subject>Membrane structure</subject><subject>Membrane structures</subject><subject>Microbiology</subject><subject>Morphology</subject><subject>Natural products</subject><subject>Penicillium</subject><subject>Short Communications</subject><subject>Soil microorganisms</subject><subject>Soils</subject><issn>0046-8991</issn><issn>0973-7715</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kU9PFjEQxhsjEQS_gKc38eKlOv23bS8mBEVNiJAo4USa7u7sa8nuFtstCXx6Cu8biB48zUzmN09m5iHkLYMPDEB_zIyDMRQ4owBWaXr3guyB1YJqzdTLmoNsqLGW7ZLXOV8BqMY26hXZFVJLyUHvkcvDeQlT6FJsgx9XP_xSUo1nKfalW_I2wX7V3q5-xjDSz5jCTa2Py7wutY9z6MI4hjKtuoQTxnUKGWt1wSg7IDuDHzO-2cZ9cn785dfRN3py-vX70eEJ7STwhUouvehFb6HlrR-a3hjRNThoD6o1mvfeC4ti0HJgirPWSMYMatM32hsPKPbJp43udWkn7Ducl3qFu05h8unWRR_c3505_HbreOOMqm9gTRV4vxVI8U_BvLgp5A7H0c8YS3ZcWcXAgjUVffcPehVLmut5lTIKlBWMVYpvqPrZnBMOT8swcA_uuY17rrrnHt1zd3VIbIZyhec1pmfp_0zdA8JpnUA</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Sang, Xu-Yan</creator><creator>Wang, Zhao-Jie</creator><creator>Yang, Ya-Bin</creator><creator>Wang, Yong-Liang</creator><creator>Xiang, Mei-Ling</creator><creator>Zhu, Dou-Ying</creator><creator>Zhou, Ying</creator><creator>Luo, Xiao-Dong</creator><creator>Zhao, Li-Xing</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1353-3717</orcidid></search><sort><creationdate>20211201</creationdate><title>Antimicrobial Natural Products Produced by Soil-Derived Fungus Penicillium cremeogriseum W1-1</title><author>Sang, Xu-Yan ; Wang, Zhao-Jie ; Yang, Ya-Bin ; Wang, Yong-Liang ; Xiang, Mei-Ling ; Zhu, Dou-Ying ; Zhou, Ying ; Luo, Xiao-Dong ; Zhao, Li-Xing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-424a3d3d90b2baf6d883c6ef7a05b872daa39e3f74f1521b84118e78d67a8a0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial agents</topic><topic>Biofilms</topic><topic>Biomedical and Life Sciences</topic><topic>Cytology</topic><topic>Diterpenes</topic><topic>Drug resistance</topic><topic>E coli</topic><topic>Fungi</topic><topic>Life Sciences</topic><topic>Medical Microbiology</topic><topic>Membrane structure</topic><topic>Membrane structures</topic><topic>Microbiology</topic><topic>Morphology</topic><topic>Natural products</topic><topic>Penicillium</topic><topic>Short Communications</topic><topic>Soil microorganisms</topic><topic>Soils</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sang, Xu-Yan</creatorcontrib><creatorcontrib>Wang, Zhao-Jie</creatorcontrib><creatorcontrib>Yang, Ya-Bin</creatorcontrib><creatorcontrib>Wang, Yong-Liang</creatorcontrib><creatorcontrib>Xiang, Mei-Ling</creatorcontrib><creatorcontrib>Zhu, Dou-Ying</creatorcontrib><creatorcontrib>Zhou, Ying</creatorcontrib><creatorcontrib>Luo, Xiao-Dong</creatorcontrib><creatorcontrib>Zhao, Li-Xing</creatorcontrib><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sang, Xu-Yan</au><au>Wang, Zhao-Jie</au><au>Yang, Ya-Bin</au><au>Wang, Yong-Liang</au><au>Xiang, Mei-Ling</au><au>Zhu, Dou-Ying</au><au>Zhou, Ying</au><au>Luo, Xiao-Dong</au><au>Zhao, Li-Xing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial Natural Products Produced by Soil-Derived Fungus Penicillium cremeogriseum W1-1</atitle><jtitle>Indian journal of microbiology</jtitle><stitle>Indian J Microbiol</stitle><date>2021-12-01</date><risdate>2021</risdate><volume>61</volume><issue>4</issue><spage>519</spage><epage>523</epage><pages>519-523</pages><issn>0046-8991</issn><eissn>0973-7715</eissn><abstract>Ten compounds (
1
–
10
) were obtained from soil-derived
Penicillium cremeogriseum
W1-1 with the antimicrobial guided isolation procedure. Among them,
4
presented broad-spectrum antimicrobial activities and its preliminary mechanisms were evaluated. Compound
4
showed growth inhibition on drug-resistant pathogenic strains
Escherichia coli
and
Candida albicans
with post-contact effect (PCE), changed the morphology and membrane structure, killed cells with leakage, inhibited the growth of
C. albicans
by eradicating biofilms. Interestingly, the fraction containing
4
presented in vivo anti-pathogenic activities in mice, indicating this indole diterpenoid alkaloid could been used as potential antimicrobial agent.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>34744207</pmid><doi>10.1007/s12088-021-00957-z</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-1353-3717</orcidid><oa>free_for_read</oa></addata></record> |
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| source | SpringerLink Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Antiinfectives and antibacterials Antimicrobial agents Biofilms Biomedical and Life Sciences Cytology Diterpenes Drug resistance E coli Fungi Life Sciences Medical Microbiology Membrane structure Membrane structures Microbiology Morphology Natural products Penicillium Short Communications Soil microorganisms Soils |
| title | Antimicrobial Natural Products Produced by Soil-Derived Fungus Penicillium cremeogriseum W1-1 |
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