Impact of Maturation on Myocardial Response to Ischemia and the Effectiveness of Remote Preconditioning in Male Rats

Aging attenuates cardiac tolerance to ischemia/reperfusion (I/R) associated with defects in protective cell signaling, however, the onset of this phenotype has not been completely investigated. This study aimed to compare changes in response to I/R and the effects of remote ischemic preconditioning...

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Veröffentlicht in:	International journal of molecular sciences 2021-10, Vol.22 (20), p.11009
Hauptverfasser:	Kindernay, Lucia, Farkasova, Veronika, Neckar, Jan, Hrdlicka, Jaroslav, Ytrehus, Kirsti, Ravingerova, Tanya
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging AKT protein Animals Apoptosis Biometrics Cell signaling Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 beta - genetics Glycogen Synthase Kinase 3 beta - metabolism Glycogens Heart Heart function Hemodynamics Ischemia Ischemic Preconditioning, Myocardial Kinases Male Maturation Muscle contraction Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardium - metabolism Nitric oxide Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Nitric-oxide synthase Phenotypes Phosphorylation Preconditioning Protein kinase C Protein Kinase C-epsilon - genetics Protein Kinase C-epsilon - metabolism Proteins Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Wistar Reperfusion Survival Ventricle
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