Inhibitory Effect of Tangeretin and Cardamonin on Human Intestinal SGLT1 Activity In Vitro and Blood Glucose Levels in Mice In Vivo

Rapid postprandial blood glucose elevation can cause lifestyle-related diseases, such as type II diabetes. The absorption of food-derived glucose is primarily mediated by sodium/glucose cotransporter 1 (SGLT1). Moderate SGLT1 inhibition can help attenuate postprandial blood glucose elevation and pre...

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Veröffentlicht in:	Nutrients 2021-09, Vol.13 (10), p.3382
Hauptverfasser:	Satsu, Hideo, Shibata, Ryosuke, Suzuki, Hiroto, Kimura, Shimon, Shimizu, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Amino Acids - metabolism Animals Blood Blood Glucose - metabolism Caco-2 Cells Chalcones - chemistry Chalcones - pharmacology CHO Cells Cloning Cricetulus Diabetes Diabetes mellitus Flavones - chemistry Flavones - pharmacology Food Fructose - metabolism Gene expression Glucose Glucose tolerance Glutamic acid Humans Hyperglycemia In vivo methods and tests Insulin Intestines - physiology Kinetics Leucine Meals Mice Mice, Inbred ICR Monosaccharides Phytochemicals Phytochemicals - pharmacology Sarcosine Sarcosine - metabolism Sodium Sodium - metabolism Sodium-Glucose Transporter 1 - antagonists & inhibitors Sodium-Glucose Transporter 1 - metabolism Tangeretin
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