Host Defense Peptides: Dual Antimicrobial and Immunomodulatory Action
The rapid rise of multidrug-resistant (MDR) bacteria has once again caused bacterial infections to become a global health concern. Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), offer a viable solution to these pathogens due to their diverse mechanisms of actions, which i...
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| Veröffentlicht in: | International journal of molecular sciences 2021-10, Vol.22 (20), p.11172 |
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| creator | Drayton, Matthew Deisinger, Julia P Ludwig, Kevin C Raheem, Nigare Müller, Anna Schneider, Tanja Straus, Suzana K |
| description | The rapid rise of multidrug-resistant (MDR) bacteria has once again caused bacterial infections to become a global health concern. Antimicrobial peptides (AMPs), also known as host defense peptides (HDPs), offer a viable solution to these pathogens due to their diverse mechanisms of actions, which include direct killing as well as immunomodulatory properties (e.g., anti-inflammatory activity). HDPs may hence provide a more robust treatment of bacterial infections. In this review, the advent of and the mechanisms that lead to antibiotic resistance will be described. HDP mechanisms of antibacterial and immunomodulatory action will be presented, with specific examples of how the HDP aurein 2.2 and a few of its derivatives, namely peptide 73 and cG4L73, function. Finally, resistance that may arise from a broader use of HDPs in a clinical setting and methods to improve biocompatibility will be briefly discussed. |
| doi_str_mv | 10.3390/ijms222011172 |
| format | Article |
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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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| subjects | Acids Anti-Infective Agents - pharmacology Anti-inflammatory agents Antibiotic resistance Antibiotics Antiinfectives and antibacterials Antimicrobial agents Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - immunology Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptides Bacteria Bacteria - drug effects Bacteria - immunology Bacterial Infections - drug therapy Bacterial Infections - immunology Bacterial Infections - microbiology Biocompatibility COVID-19 Drug resistance Drug Resistance, Bacterial Host Microbial Interactions Humans Immunomodulating Agents - pharmacology Immunomodulation Immunomodulators Inflammation Multidrug resistance Penicillin Peptides Public health Review |
| title | Host Defense Peptides: Dual Antimicrobial and Immunomodulatory Action |
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