Elucidating Carfilzomib's Induced Cardiotoxicity in an In Vivo Model of Aging: Prophylactic Potential of Metformin

Carfilzomib is a first-line proteasome inhibitor indicated for relapsed/refractory multiple myeloma (MM), with its clinical use being hampered by cardiotoxic phenomena. We have previously established a translational model of carfilzomib cardiotoxicity in young adult mice, in which metformin emerged...

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Veröffentlicht in:	International journal of molecular sciences 2021-10, Vol.22 (20), p.10956
Hauptverfasser:	Efentakis, Panagiotis, Psarakou, Garyfalia, Varela, Aimilia, Papanagnou, Eleni Dimitra, Chatzistefanou, Michail, Nikolaou, Panagiota-Efstathia, Davos, Costantinos H, Gavriatopoulou, Maria, Trougakos, Ioannis P, Dimopoulos, Meletios Athanasios, Andreadou, Ioanna, Terpos, Evangelos
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging AMP-Activated Protein Kinases - metabolism Animals Antidiabetics Autophagy Autophagy - drug effects Cardiomyopathy Cardiotoxicity Disease Echocardiography Endoplasmic reticulum Geriatrics Heart Heart - drug effects Hypertension In vivo methods and tests Kinases Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Male Medical prognosis Metformin Metformin - pharmacology Mice Mice, Inbred C57BL Microtubule-Associated Proteins - metabolism Multiple myeloma Myocardium Myocardium - cytology Myocardium - metabolism Nitric Oxide Synthase Type III - metabolism Oligopeptides - pharmacology Oxidative stress Oxidative Stress - drug effects Phagocytosis Phosphorylation Phosphorylation - drug effects Proteasome Endopeptidase Complex - metabolism Proteasome inhibitors Proteasomes Protein Phosphatase 2 - metabolism Proteins Risk analysis Risk factors Targeted cancer therapy Translation Up-Regulation - drug effects Young adults
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