HDAC1-Dependent Repression of Markers of Hepatocytes and P21 Is Involved in Development of Pediatric Liver Cancer

Epigenetic regulation of gene expression plays a critical role in the development of liver cancer; however, the molecular mechanisms of epigenetic-driven liver cancers are not well understood. The aims of this study were to examine molecular mechanisms that cause the dedifferentiation of hepatocytes...

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Veröffentlicht in:	Cellular and molecular gastroenterology and hepatology 2021-01, Vol.12 (5), p.1669-1682
Hauptverfasser:	Rivas, Maria, Johnston, Michael E., Gulati, Ruhi, Kumbaji, Meenasri, Margues Aguiar, Talita Ferreira, Timchenko, Lubov, Krepischi, Ana, Shin, Soona, Bondoc, Alexander, Tiao, Gregory, Geller, James, Timchenko, Nikolai
Format:	Artikel
Sprache:	eng
Schlagworte:	C/EBPα CCAAT-Enhancer-Binding Protein-alpha - genetics CCAAT-Enhancer-Binding Protein-alpha - metabolism Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Epigenesis, Genetic Epigenetic Gene Expression Regulation, Neoplastic HDAC1 Hepatoblastoma Hepatocytes - metabolism Hepatocytes - pathology Histone Deacetylase 1 - genetics Histone Deacetylase 1 - metabolism Humans Liver Cancer Liver Neoplasms - etiology Liver Neoplasms - metabolism Liver Neoplasms - pathology Models, Biological Multiprotein Complexes - metabolism Original Research p21-Activated Kinases - genetics p21-Activated Kinases - metabolism Promoter Regions, Genetic Protein Binding Signal Transduction Sp5
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