Urinary Proteomics of Simulated Firefighting Tasks and Its Relation to Fitness Parameters
Firefighting rescues are high-hazard activities accompanied by uncertainty, urgency, and complexity. Knowledge of the metabolic characteristics during firefighting rescues is of great value. The purpose of this study was to explore the firefighting-induced physiological responses in greater depth. T...
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| Veröffentlicht in: | International journal of environmental research and public health 2021-10, Vol.18 (20), p.10618 |
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| creator | Zhu, Ting Hu, Yuxiang Hwang, Jooyeon Zhao, Dan Huang, Libin Qiao, Liang Wei, Ankui Xu, Xin |
| description | Firefighting rescues are high-hazard activities accompanied by uncertainty, urgency, and complexity. Knowledge of the metabolic characteristics during firefighting rescues is of great value. The purpose of this study was to explore the firefighting-induced physiological responses in greater depth. The urine samples of ten firefighters were collected before and after the simulated firefighting, and the proteins in urine samples were identified by the liquid chromatography-mass spectroscopy. Blood lactate and heart rate were measured. There were 360 proteins up-regulated and 265 proteins downregulated after this simulated firefighting. Changes in protein expression were significantly related to acute inflammatory responses, immune responses, complement activation, and oxidative stress. Beta-2-microglobulin (r = 0.76,
< 0.05) and von Willebrand factors (r = 0.81,
< 0.01) were positively correlated with heart rate during simulated firefighting, and carbonic anhydrase 1 (r = 0.67,
< 0.05) were positively correlated with blood lactate after simulated firefighting. These results illustrated that Beta-2-microglobulin, von Willebrand, and carbonic anhydrase 1 could be regarded as important indicators to evaluate exercise intensity for firefighters. |
| doi_str_mv | 10.3390/ijerph182010618 |
| format | Article |
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< 0.05) and von Willebrand factors (r = 0.81,
< 0.01) were positively correlated with heart rate during simulated firefighting, and carbonic anhydrase 1 (r = 0.67,
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< 0.05) and von Willebrand factors (r = 0.81,
< 0.01) were positively correlated with heart rate during simulated firefighting, and carbonic anhydrase 1 (r = 0.67,
< 0.05) were positively correlated with blood lactate after simulated firefighting. These results illustrated that Beta-2-microglobulin, von Willebrand, and carbonic anhydrase 1 could be regarded as important indicators to evaluate exercise intensity for firefighters.</description><subject>Ability tests</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Carbonic anhydrase</subject><subject>Complement activation</subject><subject>Evacuations & rescues</subject><subject>Exercise</subject><subject>Firefighters</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Immune response</subject><subject>Inflammation</subject><subject>Lactic acid</subject><subject>Liquid chromatography</subject><subject>Mass spectroscopy</subject><subject>Metabolism</subject><subject>Oxidative stress</subject><subject>Physical Exertion</subject><subject>Physical fitness</subject><subject>Physiological responses</subject><subject>Physiology</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>Simulation</subject><subject>Urine</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkUlLBDEUhIMo7mdvEvDiZTRbp9MXQQY3EBSXg6eQTr-ZydidjEla8N_b44Z6euHlS1GVQmiPkiPOK3Ls5hAXM6oYoURStYI2qZRkJCShq7_OG2grpTkhXAlZraMNLqRiXIpN9PQYnTfxDd_GkCF0ziYcJvjedX1rMjT43EWYuOksOz_FDyY9J2x8g69ywncwIC54nMOAZQ8p4VsTTQcZYtpBaxPTJtj9mtvo8fzsYXw5ur65uBqfXo8sL4s8KqmqOAPKjeAcasKaigpT18udAKgaVZeTRpWEUNswVllmSqsayyQUghWcb6OTT91FX3fQWPA5mlYvouuGXDoYp__eeDfT0_CqVcElIWwQOPwSiOGlh5R155KFtjUeQp80K5RQhJRKDujBP3Qe-uiHeB8UV7Qol46OPykbQ0rD9_2YoUQva9P_ahte7P_O8MN_98TfAdiFlSc</recordid><startdate>20211011</startdate><enddate>20211011</enddate><creator>Zhu, Ting</creator><creator>Hu, Yuxiang</creator><creator>Hwang, Jooyeon</creator><creator>Zhao, Dan</creator><creator>Huang, Libin</creator><creator>Qiao, Liang</creator><creator>Wei, Ankui</creator><creator>Xu, Xin</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3463-0839</orcidid><orcidid>https://orcid.org/0000-0002-2416-1138</orcidid><orcidid>https://orcid.org/0000-0002-6233-8459</orcidid></search><sort><creationdate>20211011</creationdate><title>Urinary Proteomics of Simulated Firefighting Tasks and Its Relation to Fitness Parameters</title><author>Zhu, Ting ; 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Knowledge of the metabolic characteristics during firefighting rescues is of great value. The purpose of this study was to explore the firefighting-induced physiological responses in greater depth. The urine samples of ten firefighters were collected before and after the simulated firefighting, and the proteins in urine samples were identified by the liquid chromatography-mass spectroscopy. Blood lactate and heart rate were measured. There were 360 proteins up-regulated and 265 proteins downregulated after this simulated firefighting. Changes in protein expression were significantly related to acute inflammatory responses, immune responses, complement activation, and oxidative stress. Beta-2-microglobulin (r = 0.76,
< 0.05) and von Willebrand factors (r = 0.81,
< 0.01) were positively correlated with heart rate during simulated firefighting, and carbonic anhydrase 1 (r = 0.67,
< 0.05) were positively correlated with blood lactate after simulated firefighting. These results illustrated that Beta-2-microglobulin, von Willebrand, and carbonic anhydrase 1 could be regarded as important indicators to evaluate exercise intensity for firefighters.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>34682364</pmid><doi>10.3390/ijerph182010618</doi><orcidid>https://orcid.org/0000-0003-3463-0839</orcidid><orcidid>https://orcid.org/0000-0002-2416-1138</orcidid><orcidid>https://orcid.org/0000-0002-6233-8459</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Ability tests Biomarkers Blood Carbonic anhydrase Complement activation Evacuations & rescues Exercise Firefighters Heart Rate Humans Immune response Inflammation Lactic acid Liquid chromatography Mass spectroscopy Metabolism Oxidative stress Physical Exertion Physical fitness Physiological responses Physiology Proteins Proteomics Simulation Urine |
| title | Urinary Proteomics of Simulated Firefighting Tasks and Its Relation to Fitness Parameters |
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