Improved SNV Discovery in Barcode-Stratified scRNA-seq Alignments

Currently, the detection of single nucleotide variants (SNVs) from 10 x Genomics single-cell RNA sequencing data (scRNA-seq) is typically performed on the pooled sequencing reads across all cells in a sample. Here, we assess the gaining of information regarding SNV assessments from individual cell s...

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Veröffentlicht in:	Genes 2021-09, Vol.12 (10), p.1558
Hauptverfasser:	N M, Prashant, Liu, Hongyu, Dillard, Christian, Ibeawuchi, Helen, Alsaeedy, Turkey, Chan, Hang, Horvath, Anelia Dafinova
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell cycle Datasets Gene expression Gene loci Genomes Genomics Genotype & phenotype Humans MCF-7 Cells Mutation Phenotypes Polymorphism, Single Nucleotide RNA-Seq - methods Sequence Alignment - methods Single-Cell Analysis - methods Software
Online-Zugang:	Volltext
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