Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review)
The metabolic processes of endo- and exogenous compounds play an important role in diagnosing and treating patients since many metabolites are laboratory biomarkers and/or targets for therapeutic agents. Cardiac troponins are one of the most critical biomarkers to diagnose cardiovascular diseases, i...
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| Veröffentlicht in: | International journal of molecular sciences 2021-10, Vol.22 (20), p.10928 |
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| description | The metabolic processes of endo- and exogenous compounds play an important role in diagnosing and treating patients since many metabolites are laboratory biomarkers and/or targets for therapeutic agents. Cardiac troponins are one of the most critical biomarkers to diagnose cardiovascular diseases, including acute myocardial infarction. The study of troponin metabolism is of great interest as it opens up new possibilities for optimizing laboratory diagnostics. This article discusses in detail the key stages of the cardiac troponins metabolism, in particular the mechanisms of release from a healthy myocardium, mechanisms of circulation in the bloodstream, possible mechanisms of troponin penetration into other biological fluids (oral fluid, cerebrospinal fluid, pericardial and amniotic fluids), mechanisms of elimination of cardiac troponins from the blood, and daily changes in the levels of troponins in the blood. Considering these aspects of cardiac troponin metabolism, attention is focused on the potential value for clinical practice. |
| doi_str_mv | 10.3390/ijms222010928 |
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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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blood</topic><topic>Blood</topic><topic>Calcium-binding protein</topic><topic>Cardiomyocytes</topic><topic>Cardiovascular diseases</topic><topic>Cerebrospinal fluid</topic><topic>Chemical compounds</topic><topic>Clinical medicine</topic><topic>Enzymes</topic><topic>Fluids</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Ischemia</topic><topic>Laboratories</topic><topic>Literature reviews</topic><topic>Medical research</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Microscopy</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardium</topic><topic>Myocardium - metabolism</topic><topic>Myocytes, Cardiac - cytology</topic><topic>Myocytes, Cardiac - metabolism</topic><topic>Oral fluids</topic><topic>Patients</topic><topic>Pharmacology</topic><topic>Proteins</topic><topic>Radioisotopes</topic><topic>Review</topic><topic>Stem cells</topic><topic>Troponin</topic><topic>Troponin I - 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| subjects | Algorithms Amino acids Apoptosis Biomarkers Biomarkers - blood Blood Calcium-binding protein Cardiomyocytes Cardiovascular diseases Cerebrospinal fluid Chemical compounds Clinical medicine Enzymes Fluids Heart Heart attacks Humans Immunoassay Ischemia Laboratories Literature reviews Medical research Metabolism Metabolites Microscopy Myocardial infarction Myocardial Infarction - diagnosis Myocardium Myocardium - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Oral fluids Patients Pharmacology Proteins Radioisotopes Review Stem cells Troponin Troponin I - blood Troponin I - metabolism Troponin T - blood Troponin T - metabolism |
| title | Cardiac Troponins Metabolism: From Biochemical Mechanisms to Clinical Practice (Literature Review) |
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