The Importance of Extended Analysis Using Current Molecular Genetic Methods Based on the Example of a Cohort of 228 Patients with Hereditary Breast and Ovarian Cancer Syndrome

In about 20-30% of all women with breast cancer, an increased number of cases of breast cancer can be observed in their family history. However, currently, only 5-10% of all breast cancer cases can be attributed to a pathogenic gene alteration. Molecular genetic diagnostics underwent enormous develo...

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Veröffentlicht in:	Genes 2021-09, Vol.12 (10), p.1483
Hauptverfasser:	Resch, Luise D, Hotz, Alrun, Zimmer, Andreas D, Komlosi, Katalin, Singh, Nina, Tzschach, Andreas, Windfuhr-Blum, Marisa, Juhasz-Boess, Ingolf, Erbes, Thalia, Fischer, Judith, Alter, Svenja
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA1 protein BRCA1 Protein - genetics BRCA2 protein BRCA2 Protein - genetics Breast cancer Communication Female Genetic analysis Genetic Predisposition to Disease Genetic Testing Germ-Line Mutation - genetics Hereditary Breast and Ovarian Cancer Syndrome - diagnosis Hereditary Breast and Ovarian Cancer Syndrome - epidemiology Hereditary Breast and Ovarian Cancer Syndrome - genetics High-Throughput Nucleotide Sequencing Humans Middle Aged Mutation Neoplasm Proteins - genetics Next-generation sequencing Ovarian cancer Pathology, Molecular Risk Factors Risk groups Womens health
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