Molecular Targets for Gastric Cancer Treatment and Future Perspectives from a Clinical and Translational Point of View
Gastric cancer is a leading cause of cancer death worldwide. Systemic treatment comprising chemotherapy and targeted therapy is the standard of care in advanced/metastatic gastric cancer. Comprehensive molecular characterization of gastric adenocarcinomas by the TCGA Consortium and ACRG has resulted...
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| Veröffentlicht in: | Cancers 2021-10, Vol.13 (20), p.5216 |
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| creator | Körfer, Justus Lordick, Florian Hacker, Ulrich T. |
| description | Gastric cancer is a leading cause of cancer death worldwide. Systemic treatment comprising chemotherapy and targeted therapy is the standard of care in advanced/metastatic gastric cancer. Comprehensive molecular characterization of gastric adenocarcinomas by the TCGA Consortium and ACRG has resulted in the definition of distinct molecular subtypes. These efforts have in parallel built a basis for the development of novel molecularly stratified treatment approaches. Based on this molecular characterization, an increasing number of specific genomic alterations can potentially serve as treatment targets. Consequently, the development of promising compounds is ongoing. In this review, key molecular alterations in gastric and gastroesophageal junction cancers will be addressed. Finally, the current status of the translation of targeted therapy towards clinical applications will be reviewed. |
| doi_str_mv | 10.3390/cancers13205216 |
| format | Article |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Antibodies Cancer therapies Cell cycle Chemotherapy Clinical trials Datasets DNA methylation Epidermal growth factor Gastric cancer Gene amplification Gene expression Genomes Kinases Medical prognosis Metastases Metastasis Patients Proteins Review Translation Tumors |
| title | Molecular Targets for Gastric Cancer Treatment and Future Perspectives from a Clinical and Translational Point of View |
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