The Possible Role of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease
Background. As every organ within the body, the brain is also extremely susceptible to a plethora of noxious agents that change its chemistry. One component frequently found in current products against harmful species to crops is rotenone whose effect under prolonged exposure has been demonstrated t...
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| creator | Ilie, Ovidiu-Dumitru Paduraru, Emanuela Robea, Madalina-Andreea Balmus, Ioana-Miruna Jijie, Roxana Nicoara, Mircea Ciobica, Alin Nita, Ilinca-Bianca Dobrin, Romeo Doroftei, Bogdan |
| description | Background. As every organ within the body, the brain is also extremely susceptible to a plethora of noxious agents that change its chemistry. One component frequently found in current products against harmful species to crops is rotenone whose effect under prolonged exposure has been demonstrated to cause neurodegenerative disorders such as Parkinson’s disease. The latest reports have indeed revealed that rotenone promotes Parkinson’s in humans, but studies aiming to show congruent effects in zebrafish (Danio rerio) are lacking. Material and Methods. In this context, the aim of the present study was to demonstrate how chronic administration of rotenone for 3 weeks impairs the locomotor activity and sociability and induces oxidative stress in zebrafish. Results. There were no statistically significant differences following the analysis of their social interaction and locomotor tests (p>0.05). However, several exceptions have been noted in the control, rotenone, and probiotics groups when we compared their locomotor activity during the pretreatment and treatment interval (p0.05), relevant changes have been observed between the analyzed groups (p |
| doi_str_mv | 10.1155/2021/9629102 |
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As every organ within the body, the brain is also extremely susceptible to a plethora of noxious agents that change its chemistry. One component frequently found in current products against harmful species to crops is rotenone whose effect under prolonged exposure has been demonstrated to cause neurodegenerative disorders such as Parkinson’s disease. The latest reports have indeed revealed that rotenone promotes Parkinson’s in humans, but studies aiming to show congruent effects in zebrafish (Danio rerio) are lacking. Material and Methods. In this context, the aim of the present study was to demonstrate how chronic administration of rotenone for 3 weeks impairs the locomotor activity and sociability and induces oxidative stress in zebrafish. Results. There were no statistically significant differences following the analysis of their social interaction and locomotor tests (p>0.05). However, several exceptions have been noted in the control, rotenone, and probiotics groups when we compared their locomotor activity during the pretreatment and treatment interval (p<0.05). We further assessed the role of rotenone in disturbing the detoxifying system as represented by three enzymes known as superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA). Despite the fact that there were no statistically significant changes within SOD and GPx levels between the control group and rotenone, probiotics, and rotenone+probiotics (p>0.05), relevant changes have been observed between the analyzed groups (p<0.05 and p<0.005, respectively). On the other hand, significant differences (p<0.05) have been observed for MDA when we analyzed the data between the control group and the other three groups. Conclusions. Our results suggest that rotenone can be successfully used to trigger Parkinson’s disease-related symptomatology in zebrafish.</description><identifier>ISSN: 1942-0900</identifier><identifier>ISSN: 1942-0994</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2021/9629102</identifier><identifier>PMID: 34691361</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Alzheimer's disease ; Animals ; Behavior ; Bifidobacterium longum - metabolism ; Dementia ; Disease Models, Animal ; Gene expression ; Humans ; Lacticaseibacillus rhamnosus - metabolism ; Locomotion - drug effects ; Oxidative stress ; Oxidative Stress - physiology ; Parkinson Disease - etiology ; Parkinson Disease - microbiology ; Parkinson's disease ; Pesticides ; Physiology ; Probiotics ; Rotenone - adverse effects ; Social interaction ; Zebrafish</subject><ispartof>Oxidative medicine and cellular longevity, 2021, Vol.2021 (1), p.9629102</ispartof><rights>Copyright © 2021 Ovidiu-Dumitru Ilie et al.</rights><rights>Copyright © 2021 Ovidiu-Dumitru Ilie et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Ovidiu-Dumitru Ilie et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-125faa3cb4980cf6054ee04e82c1bcfeb0dff5142692572ee85f3cf6f9769fbb3</citedby><cites>FETCH-LOGICAL-c448t-125faa3cb4980cf6054ee04e82c1bcfeb0dff5142692572ee85f3cf6f9769fbb3</cites><orcidid>0000-0002-4023-1765 ; 0000-0003-3023-0205 ; 0000-0001-7293-859X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531778/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34691361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Czuczejko, Jolanta</contributor><creatorcontrib>Ilie, Ovidiu-Dumitru</creatorcontrib><creatorcontrib>Paduraru, Emanuela</creatorcontrib><creatorcontrib>Robea, Madalina-Andreea</creatorcontrib><creatorcontrib>Balmus, Ioana-Miruna</creatorcontrib><creatorcontrib>Jijie, Roxana</creatorcontrib><creatorcontrib>Nicoara, Mircea</creatorcontrib><creatorcontrib>Ciobica, Alin</creatorcontrib><creatorcontrib>Nita, Ilinca-Bianca</creatorcontrib><creatorcontrib>Dobrin, Romeo</creatorcontrib><creatorcontrib>Doroftei, Bogdan</creatorcontrib><title>The Possible Role of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Background. As every organ within the body, the brain is also extremely susceptible to a plethora of noxious agents that change its chemistry. One component frequently found in current products against harmful species to crops is rotenone whose effect under prolonged exposure has been demonstrated to cause neurodegenerative disorders such as Parkinson’s disease. The latest reports have indeed revealed that rotenone promotes Parkinson’s in humans, but studies aiming to show congruent effects in zebrafish (Danio rerio) are lacking. Material and Methods. In this context, the aim of the present study was to demonstrate how chronic administration of rotenone for 3 weeks impairs the locomotor activity and sociability and induces oxidative stress in zebrafish. Results. There were no statistically significant differences following the analysis of their social interaction and locomotor tests (p>0.05). However, several exceptions have been noted in the control, rotenone, and probiotics groups when we compared their locomotor activity during the pretreatment and treatment interval (p<0.05). We further assessed the role of rotenone in disturbing the detoxifying system as represented by three enzymes known as superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA). Despite the fact that there were no statistically significant changes within SOD and GPx levels between the control group and rotenone, probiotics, and rotenone+probiotics (p>0.05), relevant changes have been observed between the analyzed groups (p<0.05 and p<0.005, respectively). On the other hand, significant differences (p<0.05) have been observed for MDA when we analyzed the data between the control group and the other three groups. Conclusions. Our results suggest that rotenone can be successfully used to trigger Parkinson’s disease-related symptomatology in zebrafish.</description><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Behavior</subject><subject>Bifidobacterium longum - metabolism</subject><subject>Dementia</subject><subject>Disease Models, Animal</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Lacticaseibacillus rhamnosus - metabolism</subject><subject>Locomotion - drug effects</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Parkinson Disease - etiology</subject><subject>Parkinson Disease - microbiology</subject><subject>Parkinson's disease</subject><subject>Pesticides</subject><subject>Physiology</subject><subject>Probiotics</subject><subject>Rotenone - adverse effects</subject><subject>Social interaction</subject><subject>Zebrafish</subject><issn>1942-0900</issn><issn>1942-0994</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9ks9u1DAQxiMEoqVw44wscUGCUP_NxpdK3RZopYVWUC5cLMcZd10Su9hJS2-8Bg_Dy_AkON1lBRy4eMaan7-Zkb-ieEzwS0KE2KWYkl1ZUUkwvVNsE8lpiaXkdzc5xlvFg5QuMK4Y5eR-scV4JQmryHbx42wJ6DSk5JoO0PuQj2DR3FnXhkabAaIbe9QFf57DfC5YhbRv0SKXprrrujGhuNS9DylnR-8wJih4tAgm9GEIEe2bwV254eb23clX1-p8B_RhiJASch7p3HYAHzyUx74dDbToEzRRW5eW6G1ooZtGOtXxs_Mp-J_fvid06BLoBA-Le1Z3CR6t407x8fWrs4OjcnHy5vhgf1EazuuhJFRYrZlpuKyxsRUWHABzqKkhjbHQ4NZaQTitJBUzClALyzJn5ayStmnYTrG30r0cmx5aA36IulOX0fU63qignfq74t1SnYcrVQtGZrM6CzxbC8TwZYQ0qN4lA12nPYQxKSpqISnHbEKf_oNehDH6vN4tRYmoMMvUixVlYv68CHYzDMFq8oWafKHWvsj4kz8X2MC_jZCB5ytg6Xyrr93_5X4BcOLDxg</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Ilie, Ovidiu-Dumitru</creator><creator>Paduraru, Emanuela</creator><creator>Robea, Madalina-Andreea</creator><creator>Balmus, Ioana-Miruna</creator><creator>Jijie, Roxana</creator><creator>Nicoara, Mircea</creator><creator>Ciobica, Alin</creator><creator>Nita, Ilinca-Bianca</creator><creator>Dobrin, Romeo</creator><creator>Doroftei, Bogdan</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4023-1765</orcidid><orcidid>https://orcid.org/0000-0003-3023-0205</orcidid><orcidid>https://orcid.org/0000-0001-7293-859X</orcidid></search><sort><creationdate>2021</creationdate><title>The Possible Role of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease</title><author>Ilie, Ovidiu-Dumitru ; Paduraru, Emanuela ; Robea, Madalina-Andreea ; Balmus, Ioana-Miruna ; Jijie, Roxana ; Nicoara, Mircea ; Ciobica, Alin ; Nita, Ilinca-Bianca ; Dobrin, Romeo ; Doroftei, Bogdan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-125faa3cb4980cf6054ee04e82c1bcfeb0dff5142692572ee85f3cf6f9769fbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Behavior</topic><topic>Bifidobacterium longum - metabolism</topic><topic>Dementia</topic><topic>Disease Models, Animal</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Lacticaseibacillus rhamnosus - metabolism</topic><topic>Locomotion - drug effects</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Parkinson Disease - etiology</topic><topic>Parkinson Disease - microbiology</topic><topic>Parkinson's disease</topic><topic>Pesticides</topic><topic>Physiology</topic><topic>Probiotics</topic><topic>Rotenone - adverse effects</topic><topic>Social interaction</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ilie, Ovidiu-Dumitru</creatorcontrib><creatorcontrib>Paduraru, Emanuela</creatorcontrib><creatorcontrib>Robea, Madalina-Andreea</creatorcontrib><creatorcontrib>Balmus, Ioana-Miruna</creatorcontrib><creatorcontrib>Jijie, Roxana</creatorcontrib><creatorcontrib>Nicoara, Mircea</creatorcontrib><creatorcontrib>Ciobica, Alin</creatorcontrib><creatorcontrib>Nita, Ilinca-Bianca</creatorcontrib><creatorcontrib>Dobrin, Romeo</creatorcontrib><creatorcontrib>Doroftei, Bogdan</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ilie, Ovidiu-Dumitru</au><au>Paduraru, Emanuela</au><au>Robea, Madalina-Andreea</au><au>Balmus, Ioana-Miruna</au><au>Jijie, Roxana</au><au>Nicoara, Mircea</au><au>Ciobica, Alin</au><au>Nita, Ilinca-Bianca</au><au>Dobrin, Romeo</au><au>Doroftei, Bogdan</au><au>Czuczejko, Jolanta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Possible Role of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><issue>1</issue><spage>9629102</spage><pages>9629102-</pages><issn>1942-0900</issn><issn>1942-0994</issn><eissn>1942-0994</eissn><abstract>Background. As every organ within the body, the brain is also extremely susceptible to a plethora of noxious agents that change its chemistry. One component frequently found in current products against harmful species to crops is rotenone whose effect under prolonged exposure has been demonstrated to cause neurodegenerative disorders such as Parkinson’s disease. The latest reports have indeed revealed that rotenone promotes Parkinson’s in humans, but studies aiming to show congruent effects in zebrafish (Danio rerio) are lacking. Material and Methods. In this context, the aim of the present study was to demonstrate how chronic administration of rotenone for 3 weeks impairs the locomotor activity and sociability and induces oxidative stress in zebrafish. Results. There were no statistically significant differences following the analysis of their social interaction and locomotor tests (p>0.05). However, several exceptions have been noted in the control, rotenone, and probiotics groups when we compared their locomotor activity during the pretreatment and treatment interval (p<0.05). We further assessed the role of rotenone in disturbing the detoxifying system as represented by three enzymes known as superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA). Despite the fact that there were no statistically significant changes within SOD and GPx levels between the control group and rotenone, probiotics, and rotenone+probiotics (p>0.05), relevant changes have been observed between the analyzed groups (p<0.05 and p<0.005, respectively). On the other hand, significant differences (p<0.05) have been observed for MDA when we analyzed the data between the control group and the other three groups. Conclusions. Our results suggest that rotenone can be successfully used to trigger Parkinson’s disease-related symptomatology in zebrafish.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34691361</pmid><doi>10.1155/2021/9629102</doi><orcidid>https://orcid.org/0000-0002-4023-1765</orcidid><orcidid>https://orcid.org/0000-0003-3023-0205</orcidid><orcidid>https://orcid.org/0000-0001-7293-859X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Oxidative medicine and cellular longevity, 2021, Vol.2021 (1), p.9629102 |
| issn | 1942-0900 1942-0994 1942-0994 |
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| source | MEDLINE; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Alzheimer's disease Animals Behavior Bifidobacterium longum - metabolism Dementia Disease Models, Animal Gene expression Humans Lacticaseibacillus rhamnosus - metabolism Locomotion - drug effects Oxidative stress Oxidative Stress - physiology Parkinson Disease - etiology Parkinson Disease - microbiology Parkinson's disease Pesticides Physiology Probiotics Rotenone - adverse effects Social interaction Zebrafish |
| title | The Possible Role of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001 on Locomotor Activity and Oxidative Stress in a Rotenone-Induced Zebrafish Model of Parkinson’s Disease |
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