Non-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae

Objective The risks of excess sugar intake in addition to high-fat diet consumption on immunopathogenesis of obesity-associated metabolic diseases are poorly defined. Interleukin-4 (IL-4) and IL-13 signaling via IL-4Rα regulates adipose tissue lipolysis, insulin sensitivity, and liver fibrosis in ob...

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Veröffentlicht in:	International Journal of Obesity 2021-11, Vol.45 (11), p.2377-2387
Hauptverfasser:	Damen, Michelle S. M. A., Stankiewicz, Traci E., Park, Se-Hyung, Helsley, Robert N., Chan, Calvin C., Moreno-Fernandez, Maria E., Doll, Jessica R., Szabo, Sara, Herbert, De’Broski R., Softic, Samir, Divanovic, Senad
Format:	Artikel
Sprache:	eng
Schlagworte:	13/21 38/39 38/77 38/90 631/250/249/2510 64/60 692/699/249/2510 96/31 Adipose tissue Animals Body fat Body weight Body weight gain Carbohydrates Complications Damage Diet Disease Models, Animal Energy expenditure Energy metabolism Energy Metabolism - physiology Epidemiology Fatty acids Fatty liver Fibrosis Fructose Fructose - adverse effects Gene expression Glucose Glucose metabolism Health Promotion and Disease Prevention High carbohydrate diet High fat diet Immunopathogenesis Inflammation Insulin Insulin Resistance - physiology Interleukin 13 Interleukin 4 Interleukin-4 - analysis Interleukin-4 - metabolism Internal Medicine Ketohexokinase Lipolysis Locomotor activity Low fat diet Medicine Medicine & Public Health Metabolic Diseases Metabolic disorders Metabolism Mice Obesity Obesity - immunology Obesity - metabolism Oxidation Public Health Signal transduction Signaling Sugar Synthesis
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