Plasmin Cascade Mediates Thrombotic Events in SARS-CoV-2 Infection via Complement and Platelet-Activating Systems

Objective: Recently emerged beta-coronavirus SARS-CoV-2, has resulted in the current pandemic designated COVID-19. COVID-19 manifests as severe illness exhibiting systemic inflammatory response syndrome, acute respiratory distress syndrome (ARDS), thrombotic events, and shock, exacerbated further by...

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Veröffentlicht in:	IEEE open journal of engineering in medicine and biology 2020-01, Vol.1, p.220-227
Hauptverfasser:	Mukund, Kavitha, Mathee, Kalai, Subramaniam, Shankar
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical engineering Blood platelets Coagulation complement system Coronaviruses COVID-19 Epithelial cells Epithelium Fibrin Immune system In vivo methods and tests Infections Inflammation Inflammatory response Lung Lungs neutrophil extracellular traps (NETs) Pandemics Plasmin plasminogen activators Platelets Proteins Respiratory distress syndrome Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Systemic inflammatory response syndrome Thromboembolism Thrombosis Viral diseases
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