Magnetic resonance elastography to quantify liver disease severity in autosomal recessive polycystic kidney disease
Objectives To evaluate whether liver and spleen magnetic resonance elastography (MRE) can measure the severity of congenital hepatic fibrosis (CHF) and portal hypertension (pHTN) in individuals with autosomal recessive polycystic kidney disease (ARPKD), and to examine correlations between liver MRE...
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| Veröffentlicht in: | Abdominal imaging 2021-02, Vol.46 (2), p.570-580 |
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| creator | Hartung, Erum A. Calle-Toro, Juan S. Lopera, Carolina Maya Wen, Jessica Carson, Robert H. Dutt, Mohini Howarth, Kathryn Furth, Susan L. Darge, Kassa Serai, Suraj D. |
| description | Objectives
To evaluate whether liver and spleen magnetic resonance elastography (MRE) can measure the severity of congenital hepatic fibrosis (CHF) and portal hypertension (pHTN) in individuals with autosomal recessive polycystic kidney disease (ARPKD), and to examine correlations between liver MRE and ultrasound (US) elastography.
Methods
Cross-sectional study of nine individuals with ARPKD and 14 healthy controls. MRE was performed to measure mean liver and spleen stiffness (kPa); US elastography was performed to measure point shear wave speed (SWS) in both liver lobes. We compared: (1) MRE liver and spleen stiffness between controls vs. ARPKD; and (2) MRE liver stiffness between participants with ARPKD without vs. with pHTN, and examined correlations between MRE liver stiffness, spleen length, platelet counts, and US elastography SWS. Receiver operating characteristic (ROC) analysis was performed to examine diagnostic accuracy of liver MRE.
Results
Participants with ARPKD (median age 16.8 [IQR 13.3, 18.9] years) had higher median MRE liver stiffness than controls (median age 14.7 [IQR 9.7, 16.7 years) (2.55 vs. 1.92 kPa,
p
= 0.008), but MRE spleen stiffness did not differ. ARPKD participants with pHTN had higher median MRE liver stiffness than those without (3.60 kPa vs 2.49 kPa,
p
= 0.05). Liver MRE and US elastography measurements were strongly correlated. To distinguish ARPKD vs. control groups, liver MRE had 78% sensitivity and 93% specificity at a proposed cut-off of 2.48 kPa [ROC area 0.83 (95% CI 0.63–1.00)].
Conclusion
Liver MRE may be a useful quantitative method to measure the severity of CHF and pHTN in individuals with ARPKD. |
| doi_str_mv | 10.1007/s00261-020-02694-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8527769</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2430978384</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-11d6cb9cace7111b7e8032de6a0be48eb9cf2c20a935dd64831af267b5d7ca793</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhSMEolXpH2CBLLFhE7i2EzvZIKGqPKQiNiCxsxznZuqSsae-TqX8ezxMOzwWLCzbOt859tWpquccXnMA_YYAhOI1CChL9U3NH1WnQipVA7Td4-O5-X5SnRPdAABXLeeifVqdSKFbDZqfVvTZbgJm71hCisEGhwxnSzlukt1dryxHdrvYkP20stnfYWKjJ7SEjLDcfF6ZD8wuOVLc2rnEOCQqINvFeXUr7bN_-DHg-uB8Vj2Z7Ex4fr-fVd_eX369-Fhfffnw6eLdVe0a3eSa81G5oXfWoeacDxo7kGJEZWHApsMiTcIJsL1sx1E1neR2EkoP7aid1b08q94ecnfLsMXRYcjJzmaX_Nam1UTrzd9K8NdmE-9M1wqt1T7g1X1AircLUjZbTw7n2QaMCxnRSOh1J7umoC__QW_ikkIZr1A9V7IF3hVKHCiXIlHC6fgZDmZfqznUakqt5lethhfTiz_HOFoeSiyAPABUpLDB9Pvt_8T-BGvisYU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2491635018</pqid></control><display><type>article</type><title>Magnetic resonance elastography to quantify liver disease severity in autosomal recessive polycystic kidney disease</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Hartung, Erum A. ; Calle-Toro, Juan S. ; Lopera, Carolina Maya ; Wen, Jessica ; Carson, Robert H. ; Dutt, Mohini ; Howarth, Kathryn ; Furth, Susan L. ; Darge, Kassa ; Serai, Suraj D.</creator><creatorcontrib>Hartung, Erum A. ; Calle-Toro, Juan S. ; Lopera, Carolina Maya ; Wen, Jessica ; Carson, Robert H. ; Dutt, Mohini ; Howarth, Kathryn ; Furth, Susan L. ; Darge, Kassa ; Serai, Suraj D.</creatorcontrib><description>Objectives
To evaluate whether liver and spleen magnetic resonance elastography (MRE) can measure the severity of congenital hepatic fibrosis (CHF) and portal hypertension (pHTN) in individuals with autosomal recessive polycystic kidney disease (ARPKD), and to examine correlations between liver MRE and ultrasound (US) elastography.
Methods
Cross-sectional study of nine individuals with ARPKD and 14 healthy controls. MRE was performed to measure mean liver and spleen stiffness (kPa); US elastography was performed to measure point shear wave speed (SWS) in both liver lobes. We compared: (1) MRE liver and spleen stiffness between controls vs. ARPKD; and (2) MRE liver stiffness between participants with ARPKD without vs. with pHTN, and examined correlations between MRE liver stiffness, spleen length, platelet counts, and US elastography SWS. Receiver operating characteristic (ROC) analysis was performed to examine diagnostic accuracy of liver MRE.
Results
Participants with ARPKD (median age 16.8 [IQR 13.3, 18.9] years) had higher median MRE liver stiffness than controls (median age 14.7 [IQR 9.7, 16.7 years) (2.55 vs. 1.92 kPa,
p
= 0.008), but MRE spleen stiffness did not differ. ARPKD participants with pHTN had higher median MRE liver stiffness than those without (3.60 kPa vs 2.49 kPa,
p
= 0.05). Liver MRE and US elastography measurements were strongly correlated. To distinguish ARPKD vs. control groups, liver MRE had 78% sensitivity and 93% specificity at a proposed cut-off of 2.48 kPa [ROC area 0.83 (95% CI 0.63–1.00)].
Conclusion
Liver MRE may be a useful quantitative method to measure the severity of CHF and pHTN in individuals with ARPKD.</description><identifier>ISSN: 2366-004X</identifier><identifier>EISSN: 2366-0058</identifier><identifier>DOI: 10.1007/s00261-020-02694-1</identifier><identifier>PMID: 32757071</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adolescent ; Correlation analysis ; Cross-Sectional Studies ; Elasticity Imaging Techniques ; Fibrosis ; Gastroenterology ; Hepatobiliary ; Hepatology ; Humans ; Hypertension ; Imaging ; Kidney diseases ; Kidneys ; Liver ; Liver - diagnostic imaging ; Liver - pathology ; Liver Cirrhosis - diagnostic imaging ; Liver Cirrhosis - pathology ; Liver diseases ; Magnetic resonance ; Magnetic Resonance Imaging ; Medicine ; Medicine & Public Health ; Polycystic kidney ; Polycystic Kidney, Autosomal Recessive - diagnostic imaging ; Radiology ; Resonance ; Severity of Illness Index ; Spleen ; Stiffness ; Ultrasonic testing ; Ultrasound</subject><ispartof>Abdominal imaging, 2021-02, Vol.46 (2), p.570-580</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-11d6cb9cace7111b7e8032de6a0be48eb9cf2c20a935dd64831af267b5d7ca793</citedby><cites>FETCH-LOGICAL-c474t-11d6cb9cace7111b7e8032de6a0be48eb9cf2c20a935dd64831af267b5d7ca793</cites><orcidid>0000-0001-5617-6505 ; 0000-0002-6944-7471</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00261-020-02694-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00261-020-02694-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32757071$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hartung, Erum A.</creatorcontrib><creatorcontrib>Calle-Toro, Juan S.</creatorcontrib><creatorcontrib>Lopera, Carolina Maya</creatorcontrib><creatorcontrib>Wen, Jessica</creatorcontrib><creatorcontrib>Carson, Robert H.</creatorcontrib><creatorcontrib>Dutt, Mohini</creatorcontrib><creatorcontrib>Howarth, Kathryn</creatorcontrib><creatorcontrib>Furth, Susan L.</creatorcontrib><creatorcontrib>Darge, Kassa</creatorcontrib><creatorcontrib>Serai, Suraj D.</creatorcontrib><title>Magnetic resonance elastography to quantify liver disease severity in autosomal recessive polycystic kidney disease</title><title>Abdominal imaging</title><addtitle>Abdom Radiol</addtitle><addtitle>Abdom Radiol (NY)</addtitle><description>Objectives
To evaluate whether liver and spleen magnetic resonance elastography (MRE) can measure the severity of congenital hepatic fibrosis (CHF) and portal hypertension (pHTN) in individuals with autosomal recessive polycystic kidney disease (ARPKD), and to examine correlations between liver MRE and ultrasound (US) elastography.
Methods
Cross-sectional study of nine individuals with ARPKD and 14 healthy controls. MRE was performed to measure mean liver and spleen stiffness (kPa); US elastography was performed to measure point shear wave speed (SWS) in both liver lobes. We compared: (1) MRE liver and spleen stiffness between controls vs. ARPKD; and (2) MRE liver stiffness between participants with ARPKD without vs. with pHTN, and examined correlations between MRE liver stiffness, spleen length, platelet counts, and US elastography SWS. Receiver operating characteristic (ROC) analysis was performed to examine diagnostic accuracy of liver MRE.
Results
Participants with ARPKD (median age 16.8 [IQR 13.3, 18.9] years) had higher median MRE liver stiffness than controls (median age 14.7 [IQR 9.7, 16.7 years) (2.55 vs. 1.92 kPa,
p
= 0.008), but MRE spleen stiffness did not differ. ARPKD participants with pHTN had higher median MRE liver stiffness than those without (3.60 kPa vs 2.49 kPa,
p
= 0.05). Liver MRE and US elastography measurements were strongly correlated. To distinguish ARPKD vs. control groups, liver MRE had 78% sensitivity and 93% specificity at a proposed cut-off of 2.48 kPa [ROC area 0.83 (95% CI 0.63–1.00)].
Conclusion
Liver MRE may be a useful quantitative method to measure the severity of CHF and pHTN in individuals with ARPKD.</description><subject>Adolescent</subject><subject>Correlation analysis</subject><subject>Cross-Sectional Studies</subject><subject>Elasticity Imaging Techniques</subject><subject>Fibrosis</subject><subject>Gastroenterology</subject><subject>Hepatobiliary</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Imaging</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Liver</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis - diagnostic imaging</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver diseases</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Polycystic kidney</subject><subject>Polycystic Kidney, Autosomal Recessive - diagnostic imaging</subject><subject>Radiology</subject><subject>Resonance</subject><subject>Severity of Illness Index</subject><subject>Spleen</subject><subject>Stiffness</subject><subject>Ultrasonic testing</subject><subject>Ultrasound</subject><issn>2366-004X</issn><issn>2366-0058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUtv1DAUhSMEolXpH2CBLLFhE7i2EzvZIKGqPKQiNiCxsxznZuqSsae-TqX8ezxMOzwWLCzbOt859tWpquccXnMA_YYAhOI1CChL9U3NH1WnQipVA7Td4-O5-X5SnRPdAABXLeeifVqdSKFbDZqfVvTZbgJm71hCisEGhwxnSzlukt1dryxHdrvYkP20stnfYWKjJ7SEjLDcfF6ZD8wuOVLc2rnEOCQqINvFeXUr7bN_-DHg-uB8Vj2Z7Ex4fr-fVd_eX369-Fhfffnw6eLdVe0a3eSa81G5oXfWoeacDxo7kGJEZWHApsMiTcIJsL1sx1E1neR2EkoP7aid1b08q94ecnfLsMXRYcjJzmaX_Nam1UTrzd9K8NdmE-9M1wqt1T7g1X1AircLUjZbTw7n2QaMCxnRSOh1J7umoC__QW_ikkIZr1A9V7IF3hVKHCiXIlHC6fgZDmZfqznUakqt5lethhfTiz_HOFoeSiyAPABUpLDB9Pvt_8T-BGvisYU</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Hartung, Erum A.</creator><creator>Calle-Toro, Juan S.</creator><creator>Lopera, Carolina Maya</creator><creator>Wen, Jessica</creator><creator>Carson, Robert H.</creator><creator>Dutt, Mohini</creator><creator>Howarth, Kathryn</creator><creator>Furth, Susan L.</creator><creator>Darge, Kassa</creator><creator>Serai, Suraj D.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5617-6505</orcidid><orcidid>https://orcid.org/0000-0002-6944-7471</orcidid></search><sort><creationdate>20210201</creationdate><title>Magnetic resonance elastography to quantify liver disease severity in autosomal recessive polycystic kidney disease</title><author>Hartung, Erum A. ; Calle-Toro, Juan S. ; Lopera, Carolina Maya ; Wen, Jessica ; Carson, Robert H. ; Dutt, Mohini ; Howarth, Kathryn ; Furth, Susan L. ; Darge, Kassa ; Serai, Suraj D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-11d6cb9cace7111b7e8032de6a0be48eb9cf2c20a935dd64831af267b5d7ca793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Correlation analysis</topic><topic>Cross-Sectional Studies</topic><topic>Elasticity Imaging Techniques</topic><topic>Fibrosis</topic><topic>Gastroenterology</topic><topic>Hepatobiliary</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Imaging</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Liver</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - pathology</topic><topic>Liver Cirrhosis - diagnostic imaging</topic><topic>Liver Cirrhosis - pathology</topic><topic>Liver diseases</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Polycystic kidney</topic><topic>Polycystic Kidney, Autosomal Recessive - diagnostic imaging</topic><topic>Radiology</topic><topic>Resonance</topic><topic>Severity of Illness Index</topic><topic>Spleen</topic><topic>Stiffness</topic><topic>Ultrasonic testing</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hartung, Erum A.</creatorcontrib><creatorcontrib>Calle-Toro, Juan S.</creatorcontrib><creatorcontrib>Lopera, Carolina Maya</creatorcontrib><creatorcontrib>Wen, Jessica</creatorcontrib><creatorcontrib>Carson, Robert H.</creatorcontrib><creatorcontrib>Dutt, Mohini</creatorcontrib><creatorcontrib>Howarth, Kathryn</creatorcontrib><creatorcontrib>Furth, Susan L.</creatorcontrib><creatorcontrib>Darge, Kassa</creatorcontrib><creatorcontrib>Serai, Suraj D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Abdominal imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hartung, Erum A.</au><au>Calle-Toro, Juan S.</au><au>Lopera, Carolina Maya</au><au>Wen, Jessica</au><au>Carson, Robert H.</au><au>Dutt, Mohini</au><au>Howarth, Kathryn</au><au>Furth, Susan L.</au><au>Darge, Kassa</au><au>Serai, Suraj D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance elastography to quantify liver disease severity in autosomal recessive polycystic kidney disease</atitle><jtitle>Abdominal imaging</jtitle><stitle>Abdom Radiol</stitle><addtitle>Abdom Radiol (NY)</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>46</volume><issue>2</issue><spage>570</spage><epage>580</epage><pages>570-580</pages><issn>2366-004X</issn><eissn>2366-0058</eissn><abstract>Objectives
To evaluate whether liver and spleen magnetic resonance elastography (MRE) can measure the severity of congenital hepatic fibrosis (CHF) and portal hypertension (pHTN) in individuals with autosomal recessive polycystic kidney disease (ARPKD), and to examine correlations between liver MRE and ultrasound (US) elastography.
Methods
Cross-sectional study of nine individuals with ARPKD and 14 healthy controls. MRE was performed to measure mean liver and spleen stiffness (kPa); US elastography was performed to measure point shear wave speed (SWS) in both liver lobes. We compared: (1) MRE liver and spleen stiffness between controls vs. ARPKD; and (2) MRE liver stiffness between participants with ARPKD without vs. with pHTN, and examined correlations between MRE liver stiffness, spleen length, platelet counts, and US elastography SWS. Receiver operating characteristic (ROC) analysis was performed to examine diagnostic accuracy of liver MRE.
Results
Participants with ARPKD (median age 16.8 [IQR 13.3, 18.9] years) had higher median MRE liver stiffness than controls (median age 14.7 [IQR 9.7, 16.7 years) (2.55 vs. 1.92 kPa,
p
= 0.008), but MRE spleen stiffness did not differ. ARPKD participants with pHTN had higher median MRE liver stiffness than those without (3.60 kPa vs 2.49 kPa,
p
= 0.05). Liver MRE and US elastography measurements were strongly correlated. To distinguish ARPKD vs. control groups, liver MRE had 78% sensitivity and 93% specificity at a proposed cut-off of 2.48 kPa [ROC area 0.83 (95% CI 0.63–1.00)].
Conclusion
Liver MRE may be a useful quantitative method to measure the severity of CHF and pHTN in individuals with ARPKD.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32757071</pmid><doi>10.1007/s00261-020-02694-1</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-5617-6505</orcidid><orcidid>https://orcid.org/0000-0002-6944-7471</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Abdominal imaging, 2021-02, Vol.46 (2), p.570-580 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Correlation analysis Cross-Sectional Studies Elasticity Imaging Techniques Fibrosis Gastroenterology Hepatobiliary Hepatology Humans Hypertension Imaging Kidney diseases Kidneys Liver Liver - diagnostic imaging Liver - pathology Liver Cirrhosis - diagnostic imaging Liver Cirrhosis - pathology Liver diseases Magnetic resonance Magnetic Resonance Imaging Medicine Medicine & Public Health Polycystic kidney Polycystic Kidney, Autosomal Recessive - diagnostic imaging Radiology Resonance Severity of Illness Index Spleen Stiffness Ultrasonic testing Ultrasound |
| title | Magnetic resonance elastography to quantify liver disease severity in autosomal recessive polycystic kidney disease |
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