Repositioning Ivermectin for Covid-19 treatment: Molecular mechanisms of action against SARS-CoV-2 replication

Ivermectin (IVM) is an FDA approved macrocyclic lactone compound traditionally used to treat parasitic infestations and has shown to have antiviral potential from previous in-vitro studies. Currently, IVM is commercially available as a veterinary drug but have also been applied in humans to treat on...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2022-02, Vol.1868 (2), p.166294-166294, Article 166294
Hauptverfasser:	Low, Zheng Yao, Yip, Ashley Jia Wen, Lal, Sunil K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiparasitic Agents - pharmacology Antiparasitic Agents - therapeutic use Antiviral Antiviral Agents - pharmacology Antiviral Agents - therapeutic use COVID-19 - metabolism COVID-19 Drug Treatment Cytokine Release Syndrome - drug therapy Cytokine Release Syndrome - metabolism Cytokine storm Drug Repositioning Drug repurposing Humans Importin heterodimer complex Inhibition Ivermectin - pharmacology Ivermectin - therapeutic use Karyopherins - metabolism SARS-CoV-2 - drug effects SARS-CoV-2 - physiology STAT3 Streptomyces avermitilis Treatment Viral 3CLpro Virus Replication - drug effects
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