Tanshinone IIA and Astragaloside IV Inhibit miR-223/JAK2/STAT1 Signalling Pathway to Alleviate Lipopolysaccharide-Induced Damage in Nucleus Pulposus Cells

Astragaloside IV (AS IV) and tanshinone (TS IIA) are the main natural components of Salvia miltiorrhiza and Radix Astragali, respectively. The amalgam of TS IIA and AS IV has potential therapeutic value in many inflammation-related diseases. However, the aftereffect of TS IIA and AS IV for lumbar di...

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Veröffentlicht in:	Disease markers 2021, Vol.2021, p.6554480-12
Hauptverfasser:	Du, Xiaoxun, Wang, Xiaoying, Cui, Kaiying, Chen, Yungang, Zhang, Chao, Yao, Kang, Hao, Yanke, Chen, Yuanzhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Abietanes - pharmacology Antibodies Apoptosis Apoptosis - drug effects Apoptosis - physiology Caspase-1 Caspase-3 Cell injury Cell survival Cells, Cultured Degenerative disc disease Down-Regulation - drug effects Enzyme-linked immunosorbent assay Flow cytometry Gelatinase B Gene Expression Regulation - drug effects Humans Inflammation Inflammatory response Interleukin 6 Intervertebral Disc Degeneration - pathology Intervertebral discs Janus kinase 2 Janus Kinase 2 - genetics Janus Kinase 2 - metabolism Lipopolysaccharides MicroRNAs - metabolism Nuclei (cytology) Nucleus pulposus Nucleus Pulposus - drug effects Nucleus Pulposus - metabolism Nucleus Pulposus - pathology Polymerase chain reaction Proteins RNA-directed DNA polymerase Saponins - pharmacology Signal transduction Signal Transduction - drug effects Stat1 protein STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism Survival Tanshinones Transfection Triterpenes - pharmacology Tumor necrosis factor-α Viruses Western blotting
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