Comparison of three left atrial appendage occlusion devices for stroke prevention in patients with non-valvular atrial fibrillation: a single-centre seven-year experience with WATCHMAN, AMPLATZER Cardiac Plug/Amulet, LAmbre: Comparison of three LAAO devices for stroke prevention
We aimed to compare long-term "real-world" outcomes of three left atrial appendage occlusion (LAAO) devices for stroke prevention in a Chinese population with non-valvular atrial fibrillation (NVAF). Consecutive patients who underwent LAAO from June 2009 to October 2016 at a university-aff...
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| creator | Cheung, Gary Sh So, Kent Cy Chan, Christy Ky Chan, Anna Ky Lee, Alex Pui-Wai Lam, Yat-Yin Yan, Bryan P |
| description | We aimed to compare long-term "real-world" outcomes of three left atrial appendage occlusion (LAAO) devices for stroke prevention in a Chinese population with non-valvular atrial fibrillation (NVAF).
Consecutive patients who underwent LAAO from June 2009 to October 2016 at a university-affiliated hospital were retrospectively analysed. In-hospital and major adverse events (MAE) including mortality, stroke and major bleeding rates were compared by LAAO device. One hundred and sixty-one (161) patients (mean age 71.4±8.2 years; 67.7% male) with mean CHA
DS
-VASc score of 4.1±1.6 and HAS-BLED score of 2.9±1.1 underwent 162 LAAO procedures, of which 47.5% (n=77), 41.4% (n=67) and 11.1% (n=18) were AMPLATZER Cardiac Plug (ACP)/Amulet, WATCHMAN and LAmbre, respectively. The procedural success rate was 97.5% (158/162). The in-hospital adverse event rate was 7.4% (12/162) and comparable among devices (p=NS). Mean follow-up duration was 28.3±24.4 months (373 patient-years). There were no significant differences in long-term MAE rates among devices (p=NS). Observed annual ischaemic stroke (1.1% vs. 5.1%, p |
| doi_str_mv | 10.4244/AIJ-D-18-00013 |
| format | Article |
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Consecutive patients who underwent LAAO from June 2009 to October 2016 at a university-affiliated hospital were retrospectively analysed. In-hospital and major adverse events (MAE) including mortality, stroke and major bleeding rates were compared by LAAO device. One hundred and sixty-one (161) patients (mean age 71.4±8.2 years; 67.7% male) with mean CHA
DS
-VASc score of 4.1±1.6 and HAS-BLED score of 2.9±1.1 underwent 162 LAAO procedures, of which 47.5% (n=77), 41.4% (n=67) and 11.1% (n=18) were AMPLATZER Cardiac Plug (ACP)/Amulet, WATCHMAN and LAmbre, respectively. The procedural success rate was 97.5% (158/162). The in-hospital adverse event rate was 7.4% (12/162) and comparable among devices (p=NS). Mean follow-up duration was 28.3±24.4 months (373 patient-years). There were no significant differences in long-term MAE rates among devices (p=NS). Observed annual ischaemic stroke (1.1% vs. 5.1%, p<0.001) and major bleeding rates (2.7% vs. 4.5%, p=NS) were lower compared with the predicted rates, respectively.
The WATCHMAN, ACP/Amulet and LAmbre LAAO devices demonstrated similar long-term safety and efficacy in prevention of ischaemic stroke and major bleeding in patients with NVAF.</description><identifier>ISSN: 2426-3958</identifier><identifier>EISSN: 2491-0929</identifier><identifier>DOI: 10.4244/AIJ-D-18-00013</identifier><identifier>PMID: 34912974</identifier><language>eng</language><publisher>France: Europa Edition</publisher><subject>Atrial Fibrillation ; Bleeding ; Clinical Research ; Death ; Specific Closure Device/Technique ; Stroke</subject><ispartof>AsiaIntervention, 2019-02, Vol.5 (1), p.57-63</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525730/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525730/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34912974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheung, Gary Sh</creatorcontrib><creatorcontrib>So, Kent Cy</creatorcontrib><creatorcontrib>Chan, Christy Ky</creatorcontrib><creatorcontrib>Chan, Anna Ky</creatorcontrib><creatorcontrib>Lee, Alex Pui-Wai</creatorcontrib><creatorcontrib>Lam, Yat-Yin</creatorcontrib><creatorcontrib>Yan, Bryan P</creatorcontrib><title>Comparison of three left atrial appendage occlusion devices for stroke prevention in patients with non-valvular atrial fibrillation: a single-centre seven-year experience with WATCHMAN, AMPLATZER Cardiac Plug/Amulet, LAmbre: Comparison of three LAAO devices for stroke prevention</title><title>AsiaIntervention</title><addtitle>AsiaIntervention</addtitle><description>We aimed to compare long-term "real-world" outcomes of three left atrial appendage occlusion (LAAO) devices for stroke prevention in a Chinese population with non-valvular atrial fibrillation (NVAF).
Consecutive patients who underwent LAAO from June 2009 to October 2016 at a university-affiliated hospital were retrospectively analysed. In-hospital and major adverse events (MAE) including mortality, stroke and major bleeding rates were compared by LAAO device. One hundred and sixty-one (161) patients (mean age 71.4±8.2 years; 67.7% male) with mean CHA
DS
-VASc score of 4.1±1.6 and HAS-BLED score of 2.9±1.1 underwent 162 LAAO procedures, of which 47.5% (n=77), 41.4% (n=67) and 11.1% (n=18) were AMPLATZER Cardiac Plug (ACP)/Amulet, WATCHMAN and LAmbre, respectively. The procedural success rate was 97.5% (158/162). The in-hospital adverse event rate was 7.4% (12/162) and comparable among devices (p=NS). Mean follow-up duration was 28.3±24.4 months (373 patient-years). There were no significant differences in long-term MAE rates among devices (p=NS). Observed annual ischaemic stroke (1.1% vs. 5.1%, p<0.001) and major bleeding rates (2.7% vs. 4.5%, p=NS) were lower compared with the predicted rates, respectively.
The WATCHMAN, ACP/Amulet and LAmbre LAAO devices demonstrated similar long-term safety and efficacy in prevention of ischaemic stroke and major bleeding in patients with NVAF.</description><subject>Atrial Fibrillation</subject><subject>Bleeding</subject><subject>Clinical Research</subject><subject>Death</subject><subject>Specific Closure Device/Technique</subject><subject>Stroke</subject><issn>2426-3958</issn><issn>2491-0929</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kktv1TAQhQMC0ap0CzvkJYua-pGXu0CyLgWKUlqhIiQ2keNM7jU4cbCTQP89Dm0RSIjV2Joz39EZO0meUPIiZWl6LM_e4VeYlpgQQvn9ZJ-lgmIimHiwnlmOucjKveQwhC9RwgTjNEsfJXs86pgo0v17TzeuH5U3wQ3IdWjaeQBkoZuQmrxRFqlxhKFVW0BOazsHE4UtLEZDQJ3zKEzefQU0elhgmNauGdCoJhNvAX030w4NbsCLsstslb_Ddqbxxlq1TpwghYIZthawjlMeUFhh-BqiHn6M4CNMww3sk7zavD2X74-QPL-s5NXn0w9oo3xrlEaXdt4ey362MB2hSvaNhxP0r4CVlBf_T_E4edgpG-Dwth4kH1-fRmdcXbw528gKj5RSgnlLWpICzbNGtZQzpbOG0oZnqhRUF3lTdpSUoqClhli7tGhE3jWQQlZwTRU_SF7ecMe56aH9lV_ZevSmV_66dsrUf3cGs6u3bqnLjEUEiYDntwDvvs0Qpro3QUNc7QBuDjXLKYmPXYpV-uxPr98md7-B_wQDgL2k</recordid><startdate>201902</startdate><enddate>201902</enddate><creator>Cheung, Gary Sh</creator><creator>So, Kent Cy</creator><creator>Chan, Christy Ky</creator><creator>Chan, Anna Ky</creator><creator>Lee, Alex Pui-Wai</creator><creator>Lam, Yat-Yin</creator><creator>Yan, Bryan P</creator><general>Europa Edition</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201902</creationdate><title>Comparison of three left atrial appendage occlusion devices for stroke prevention in patients with non-valvular atrial fibrillation: a single-centre seven-year experience with WATCHMAN, AMPLATZER Cardiac Plug/Amulet, LAmbre: Comparison of three LAAO devices for stroke prevention</title><author>Cheung, Gary Sh ; So, Kent Cy ; Chan, Christy Ky ; Chan, Anna Ky ; Lee, Alex Pui-Wai ; Lam, Yat-Yin ; Yan, Bryan P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1110-3d0d04e165bad132ac5b11b35a891c76b8f1089718ce089f47b96fbe4e573c1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Atrial Fibrillation</topic><topic>Bleeding</topic><topic>Clinical Research</topic><topic>Death</topic><topic>Specific Closure Device/Technique</topic><topic>Stroke</topic><toplevel>online_resources</toplevel><creatorcontrib>Cheung, Gary Sh</creatorcontrib><creatorcontrib>So, Kent Cy</creatorcontrib><creatorcontrib>Chan, Christy Ky</creatorcontrib><creatorcontrib>Chan, Anna Ky</creatorcontrib><creatorcontrib>Lee, Alex Pui-Wai</creatorcontrib><creatorcontrib>Lam, Yat-Yin</creatorcontrib><creatorcontrib>Yan, Bryan P</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>AsiaIntervention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheung, Gary Sh</au><au>So, Kent Cy</au><au>Chan, Christy Ky</au><au>Chan, Anna Ky</au><au>Lee, Alex Pui-Wai</au><au>Lam, Yat-Yin</au><au>Yan, Bryan P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of three left atrial appendage occlusion devices for stroke prevention in patients with non-valvular atrial fibrillation: a single-centre seven-year experience with WATCHMAN, AMPLATZER Cardiac Plug/Amulet, LAmbre: Comparison of three LAAO devices for stroke prevention</atitle><jtitle>AsiaIntervention</jtitle><addtitle>AsiaIntervention</addtitle><date>2019-02</date><risdate>2019</risdate><volume>5</volume><issue>1</issue><spage>57</spage><epage>63</epage><pages>57-63</pages><issn>2426-3958</issn><eissn>2491-0929</eissn><abstract>We aimed to compare long-term "real-world" outcomes of three left atrial appendage occlusion (LAAO) devices for stroke prevention in a Chinese population with non-valvular atrial fibrillation (NVAF).
Consecutive patients who underwent LAAO from June 2009 to October 2016 at a university-affiliated hospital were retrospectively analysed. In-hospital and major adverse events (MAE) including mortality, stroke and major bleeding rates were compared by LAAO device. One hundred and sixty-one (161) patients (mean age 71.4±8.2 years; 67.7% male) with mean CHA
DS
-VASc score of 4.1±1.6 and HAS-BLED score of 2.9±1.1 underwent 162 LAAO procedures, of which 47.5% (n=77), 41.4% (n=67) and 11.1% (n=18) were AMPLATZER Cardiac Plug (ACP)/Amulet, WATCHMAN and LAmbre, respectively. The procedural success rate was 97.5% (158/162). The in-hospital adverse event rate was 7.4% (12/162) and comparable among devices (p=NS). Mean follow-up duration was 28.3±24.4 months (373 patient-years). There were no significant differences in long-term MAE rates among devices (p=NS). Observed annual ischaemic stroke (1.1% vs. 5.1%, p<0.001) and major bleeding rates (2.7% vs. 4.5%, p=NS) were lower compared with the predicted rates, respectively.
The WATCHMAN, ACP/Amulet and LAmbre LAAO devices demonstrated similar long-term safety and efficacy in prevention of ischaemic stroke and major bleeding in patients with NVAF.</abstract><cop>France</cop><pub>Europa Edition</pub><pmid>34912974</pmid><doi>10.4244/AIJ-D-18-00013</doi><tpages>7</tpages></addata></record> |
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| source | EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Atrial Fibrillation Bleeding Clinical Research Death Specific Closure Device/Technique Stroke |
| title | Comparison of three left atrial appendage occlusion devices for stroke prevention in patients with non-valvular atrial fibrillation: a single-centre seven-year experience with WATCHMAN, AMPLATZER Cardiac Plug/Amulet, LAmbre: Comparison of three LAAO devices for stroke prevention |
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