The transcription factor CREB1 is a mechanistic driver of immunogenicity and reduced HIV-1 acquisition following ALVAC vaccination

Development of effective human immunodeficiency virus 1 (HIV-1) vaccines requires synergy between innate and adaptive immune cells. Here we show that induction of the transcription factor CREB1 and its target genes by the recombinant canarypox vector ALVAC + Alum augments immunogenicity in non-human...

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Veröffentlicht in:	Nature immunology 2021-10, Vol.22 (10), p.1294-1305
Hauptverfasser:	Tomalka, Jeffrey Alan, Pelletier, Adam Nicolas, Fourati, Slim, Latif, Muhammad Bilal, Sharma, Ashish, Furr, Kathryn, Carlson, Kevin, Lifton, Michelle, Gonzalez, Ana, Wilkinson, Peter, Franchini, Genoveffa, Parks, Robert, Letvin, Norman, Yates, Nicole, Seaton, Kelly, Tomaras, Georgia, Tartaglia, Jim, Robb, Merlin L., Michael, Nelson L., Koup, Richard, Haynes, Barton, Santra, Sampa, Sekaly, Rafick Pierre
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250 631/250/1619 631/250/262 631/250/590 631/250/98 Adaptive immunity Adjuvants Adjuvants, Immunologic - pharmacology AIDS vaccines AIDS Vaccines - immunology Animals Antigen presentation B-Lymphocytes - immunology Biomedical and Life Sciences Biomedicine CD4 antigen CD4-Positive T-Lymphocytes - immunology Chemokines Cyclic AMP Response Element-Binding Protein - immunology Cytokines Gene expression Gene Expression - immunology Genetic Vectors - immunology Health aspects HIV HIV Antibodies - immunology HIV infection HIV Infections - immunology HIV Infections - virology HIV-1 - immunology Human immunodeficiency virus Humans Immune system Immunization Immunization - methods Immunogenicity Immunogenicity, Vaccine - immunology Immunology Infectious Diseases Lymphocytes B Lymphocytes T Prevention Primates - immunology Primates - virology Risk factors Testing Transcription activation Transcription factors Vaccination - methods Vaccine efficacy Vaccines Viral Vaccines - immunology
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