KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2

Epigenetic abnormalities are frequently involved in the initiation and progression of cancers, including acute myeloid leukemia (AML). A subtype of AML, acute promyelocytic leukemia (APL), is mainly driven by a specific oncogenic fusion event of promyelocytic leukemia–RA receptor fusion oncoprotein...

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Veröffentlicht in:	Blood advances 2021-09, Vol.5 (17), p.3241-3253
Hauptverfasser:	Xu, Siyuan, Wang, Siqing, Xing, Shenghui, Yu, Dingdang, Rong, Bowen, Gao, Hai, Sheng, Mengyao, Tan, Yun, Zhang, Yifan, Sun, Xiaojian, Wang, Kankan, Xue, Kai, Shi, Zhennan, Lan, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Differentiation Gene Expression Humans Leukemia, Promyelocytic, Acute - genetics Myeloid Neoplasia Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Retinoblastoma-Binding Protein 2
Online-Zugang:	Volltext
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