Structure–Function Analysis of Resistance to Bamlanivimab by SARS-CoV‑2 Variants Kappa, Delta, and Lambda

The newly emerging Kappa, Delta, and Lambda SARS-CoV-2 variants are worrisome, characterized with the double mutations E484Q/L452R, T478K/L452R, and F490S/L452Q, respectively, in their receptor binding domains (RBDs) of the spike proteins. As revealed in crystal structures, most of these residues (e...

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Veröffentlicht in:	Journal of chemical information and modeling 2021-10, Vol.61 (10), p.5133-5140
Hauptverfasser:	Liu, Shufeng, Huynh, Tien, Stauft, Charles B, Wang, Tony T, Luan, Binquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Binding Computational Chemistry Crystal structure Function analysis Molecular dynamics Mutation Neutralizing Residues Severe acute respiratory syndrome coronavirus 2 Viral diseases
Online-Zugang:	Volltext
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