Recent advances in the detection of interferon-gamma as a TB biomarker
Tuberculosis (TB) is one of the main infectious diseases worldwide and accounts for many deaths. It is caused by Mycobacterium tuberculosis usually affecting the lungs of patients. Early diagnosis and treatment are essential to control the TB epidemic. Interferon-gamma (IFN-γ) is a cytokine that pla...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2022-01, Vol.414 (2), p.907-921 |
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| creator | Januarie, Kaylin Cleo Uhuo, Onyinyechi V. Iwuoha, Emmanuel Feleni, Usisipho |
| description | Tuberculosis (TB) is one of the main infectious diseases worldwide and accounts for many deaths. It is caused by
Mycobacterium tuberculosis
usually affecting the lungs of patients. Early diagnosis and treatment are essential to control the TB epidemic. Interferon-gamma (IFN-γ) is a cytokine that plays a part in the body’s immune response when fighting infection. Current conventional antibody-based TB sensing techniques which are commonly used include enzyme-linked immunosorbent assay (ELISA) and interferon-gamma release assays (IGRAs). However, these methods have major drawbacks, such as being time-consuming, low sensitivity, and inability to distinguish between the different stages of the TB disease. Several electrochemical biosensor systems have been reported for the detection of interferon-gamma with high sensitivity and selectivity. Microfluidic techniques coupled with multiplex analysis in regular format and as lab-on-chip platforms have also been reported for the detection of IFN-γ. This article is a review of the techniques for detection of interferon-gamma as a TB disease biomarker. The objective is to provide a concise assessment of the available IFN-γ detection techniques (including conventional assays, biosensors, microfluidics, and multiplex analysis) and their ability to distinguish the different stages of the TB disease. |
| doi_str_mv | 10.1007/s00216-021-03702-z |
| format | Article |
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Mycobacterium tuberculosis
usually affecting the lungs of patients. Early diagnosis and treatment are essential to control the TB epidemic. Interferon-gamma (IFN-γ) is a cytokine that plays a part in the body’s immune response when fighting infection. Current conventional antibody-based TB sensing techniques which are commonly used include enzyme-linked immunosorbent assay (ELISA) and interferon-gamma release assays (IGRAs). However, these methods have major drawbacks, such as being time-consuming, low sensitivity, and inability to distinguish between the different stages of the TB disease. Several electrochemical biosensor systems have been reported for the detection of interferon-gamma with high sensitivity and selectivity. Microfluidic techniques coupled with multiplex analysis in regular format and as lab-on-chip platforms have also been reported for the detection of IFN-γ. This article is a review of the techniques for detection of interferon-gamma as a TB disease biomarker. The objective is to provide a concise assessment of the available IFN-γ detection techniques (including conventional assays, biosensors, microfluidics, and multiplex analysis) and their ability to distinguish the different stages of the TB disease.</description><identifier>ISSN: 1618-2642</identifier><identifier>EISSN: 1618-2650</identifier><identifier>DOI: 10.1007/s00216-021-03702-z</identifier><identifier>PMID: 34665279</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Analytical Chemistry ; Antibodies ; Assaying ; Biochemistry ; Biomarkers ; Biomarkers - metabolism ; Biosensors ; Characterization and Evaluation of Materials ; Chemistry ; Chemistry and Materials Science ; Cytokines ; Detectors ; Diagnosis ; Disease ; Disease control ; Early Diagnosis ; Electrochemistry ; Enzyme-linked immunosorbent assay ; Food Science ; Humans ; Immune response ; Immune system ; Infectious diseases ; Interferon ; Interferon gamma ; Interferon-gamma - metabolism ; Lab-on-a-chip ; Laboratory Medicine ; Methods ; Microfluidics ; Monitoring/Environmental Analysis ; Multiplexing ; Reproducibility of Results ; Review ; Selectivity ; Sensitivity and Specificity ; Tuberculosis ; Tuberculosis - diagnosis ; Tuberculosis - metabolism ; γ-Interferon</subject><ispartof>Analytical and bioanalytical chemistry, 2022-01, Vol.414 (2), p.907-921</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-ba3c94844e031fd992f30e528298cd4523a7596b2e360356147762b1b0c0bf6f3</citedby><cites>FETCH-LOGICAL-c541t-ba3c94844e031fd992f30e528298cd4523a7596b2e360356147762b1b0c0bf6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00216-021-03702-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00216-021-03702-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34665279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Januarie, Kaylin Cleo</creatorcontrib><creatorcontrib>Uhuo, Onyinyechi V.</creatorcontrib><creatorcontrib>Iwuoha, Emmanuel</creatorcontrib><creatorcontrib>Feleni, Usisipho</creatorcontrib><title>Recent advances in the detection of interferon-gamma as a TB biomarker</title><title>Analytical and bioanalytical chemistry</title><addtitle>Anal Bioanal Chem</addtitle><addtitle>Anal Bioanal Chem</addtitle><description>Tuberculosis (TB) is one of the main infectious diseases worldwide and accounts for many deaths. It is caused by
Mycobacterium tuberculosis
usually affecting the lungs of patients. Early diagnosis and treatment are essential to control the TB epidemic. Interferon-gamma (IFN-γ) is a cytokine that plays a part in the body’s immune response when fighting infection. Current conventional antibody-based TB sensing techniques which are commonly used include enzyme-linked immunosorbent assay (ELISA) and interferon-gamma release assays (IGRAs). However, these methods have major drawbacks, such as being time-consuming, low sensitivity, and inability to distinguish between the different stages of the TB disease. Several electrochemical biosensor systems have been reported for the detection of interferon-gamma with high sensitivity and selectivity. Microfluidic techniques coupled with multiplex analysis in regular format and as lab-on-chip platforms have also been reported for the detection of IFN-γ. This article is a review of the techniques for detection of interferon-gamma as a TB disease biomarker. The objective is to provide a concise assessment of the available IFN-γ detection techniques (including conventional assays, biosensors, microfluidics, and multiplex analysis) and their ability to distinguish the different stages of the TB disease.</description><subject>Analysis</subject><subject>Analytical Chemistry</subject><subject>Antibodies</subject><subject>Assaying</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Biosensors</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cytokines</subject><subject>Detectors</subject><subject>Diagnosis</subject><subject>Disease</subject><subject>Disease control</subject><subject>Early Diagnosis</subject><subject>Electrochemistry</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Food Science</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Infectious diseases</subject><subject>Interferon</subject><subject>Interferon gamma</subject><subject>Interferon-gamma - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Analytical and bioanalytical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Januarie, Kaylin Cleo</au><au>Uhuo, Onyinyechi V.</au><au>Iwuoha, Emmanuel</au><au>Feleni, Usisipho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent advances in the detection of interferon-gamma as a TB biomarker</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><stitle>Anal Bioanal Chem</stitle><addtitle>Anal Bioanal Chem</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>414</volume><issue>2</issue><spage>907</spage><epage>921</epage><pages>907-921</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>Tuberculosis (TB) is one of the main infectious diseases worldwide and accounts for many deaths. It is caused by
Mycobacterium tuberculosis
usually affecting the lungs of patients. Early diagnosis and treatment are essential to control the TB epidemic. Interferon-gamma (IFN-γ) is a cytokine that plays a part in the body’s immune response when fighting infection. Current conventional antibody-based TB sensing techniques which are commonly used include enzyme-linked immunosorbent assay (ELISA) and interferon-gamma release assays (IGRAs). However, these methods have major drawbacks, such as being time-consuming, low sensitivity, and inability to distinguish between the different stages of the TB disease. Several electrochemical biosensor systems have been reported for the detection of interferon-gamma with high sensitivity and selectivity. Microfluidic techniques coupled with multiplex analysis in regular format and as lab-on-chip platforms have also been reported for the detection of IFN-γ. This article is a review of the techniques for detection of interferon-gamma as a TB disease biomarker. The objective is to provide a concise assessment of the available IFN-γ detection techniques (including conventional assays, biosensors, microfluidics, and multiplex analysis) and their ability to distinguish the different stages of the TB disease.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34665279</pmid><doi>10.1007/s00216-021-03702-z</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Analytical Chemistry Antibodies Assaying Biochemistry Biomarkers Biomarkers - metabolism Biosensors Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Cytokines Detectors Diagnosis Disease Disease control Early Diagnosis Electrochemistry Enzyme-linked immunosorbent assay Food Science Humans Immune response Immune system Infectious diseases Interferon Interferon gamma Interferon-gamma - metabolism Lab-on-a-chip Laboratory Medicine Methods Microfluidics Monitoring/Environmental Analysis Multiplexing Reproducibility of Results Review Selectivity Sensitivity and Specificity Tuberculosis Tuberculosis - diagnosis Tuberculosis - metabolism γ-Interferon |
| title | Recent advances in the detection of interferon-gamma as a TB biomarker |
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