The Effect of Oral Vitamin E on Semen Parameters and IVF Outcome: A Double-Blinded Randomized Placebo-Controlled Clinical Trial
Background. Male infertility is a main clinical problem that affects about 7% of all men worldwide. Many patients with male infertility are caused by a reduced antioxidant capacity of semen. Several antioxidant supplements, especially vitamin E, are proposed to help male infertility treatment. This...
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| description | Background. Male infertility is a main clinical problem that affects about 7% of all men worldwide. Many patients with male infertility are caused by a reduced antioxidant capacity of semen. Several antioxidant supplements, especially vitamin E, are proposed to help male infertility treatment. This project was goaled to study the effects of oral synthetic vitamin E (400 IU/day) for eight weeks on betterment of semen parameters and pregnancy rate. Methods. After dropping the cases, 124 infertile couples with a male factor who were admitted to the IVF program were included. The male patients with idiopathic abnormal motility and/or morphology were randomized into two groups: 61 receiving vitamin E and 63 as the control group receiving placebo for eight weeks. The pretreatment semen parameters of both groups were compared with those of posttreatment. The pregnancy outcomes were considered between the two groups. Results. There were no significant differences statistically between before and after treatment in the term of sperm volume, count, motility, and morphology. Furthermore, the IVF outcomes of the two groups were not different significantly, either. Interestingly, the percent of normal sperm in the placebo group was significantly decreased after eight weeks. Conclusion. Vitamin E supplementation might neutralize free radical activity to keep sperm from more oxidative damages. Further studies regarding the influence of higher acceptable doses of vitamin E on semen characteristics and fertility rates are needed. This study was registered as a two-arm, blinded, randomized, placebo-controlled clinical trial (IRCTID: IRCT2014020616506N1, 2014-03-18). |
| doi_str_mv | 10.1155/2021/5588275 |
| format | Article |
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Male infertility is a main clinical problem that affects about 7% of all men worldwide. Many patients with male infertility are caused by a reduced antioxidant capacity of semen. Several antioxidant supplements, especially vitamin E, are proposed to help male infertility treatment. This project was goaled to study the effects of oral synthetic vitamin E (400 IU/day) for eight weeks on betterment of semen parameters and pregnancy rate. Methods. After dropping the cases, 124 infertile couples with a male factor who were admitted to the IVF program were included. The male patients with idiopathic abnormal motility and/or morphology were randomized into two groups: 61 receiving vitamin E and 63 as the control group receiving placebo for eight weeks. The pretreatment semen parameters of both groups were compared with those of posttreatment. The pregnancy outcomes were considered between the two groups. Results. There were no significant differences statistically between before and after treatment in the term of sperm volume, count, motility, and morphology. Furthermore, the IVF outcomes of the two groups were not different significantly, either. Interestingly, the percent of normal sperm in the placebo group was significantly decreased after eight weeks. Conclusion. Vitamin E supplementation might neutralize free radical activity to keep sperm from more oxidative damages. Further studies regarding the influence of higher acceptable doses of vitamin E on semen characteristics and fertility rates are needed. This study was registered as a two-arm, blinded, randomized, placebo-controlled clinical trial (IRCTID: IRCT2014020616506N1, 2014-03-18).</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2021/5588275</identifier><identifier>PMID: 34671676</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Abortion ; Administration, Oral ; Adult ; Age ; Analysis ; Antioxidants ; Antioxidants - administration & dosage ; Birth Rate ; Care and treatment ; Clinical trials ; Dietary supplements ; Dosage and administration ; Double-Blind Method ; Female ; Fertility ; Fertilization in vitro ; Fertilization in Vitro - methods ; Free radicals ; Health aspects ; Humans ; In vitro fertilization ; Infertility ; Infertility, Male ; Infertility, Male - drug therapy ; Infertility, Male - physiopathology ; Lipid peroxidation ; Male ; Medical treatment ; Morphology ; Motility ; Oxidative stress ; Parameters ; Patient outcomes ; Patients ; Physiological aspects ; Placebos ; Pregnancy ; Pregnancy Rate ; Properties ; Reproductive technologies ; Semen ; Semen - drug effects ; Semen - metabolism ; Sperm ; Sperm Count - methods ; Statistical analysis ; Testing ; Tocopherol ; Vitamin C ; Vitamin E ; Vitamin E - administration & dosage</subject><ispartof>BioMed research international, 2021, Vol.2021, p.5588275-6</ispartof><rights>Copyright © 2021 Soudabeh Sabetian et al.</rights><rights>COPYRIGHT 2021 John Wiley & Sons, Inc.</rights><rights>Copyright © 2021 Soudabeh Sabetian et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Soudabeh Sabetian et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-83c5b3ce5d445a033d160c1e360f8b6d1ab56dc6f5b882c449c27c04435c9b6f3</citedby><cites>FETCH-LOGICAL-c504t-83c5b3ce5d445a033d160c1e360f8b6d1ab56dc6f5b882c449c27c04435c9b6f3</cites><orcidid>0000-0002-4215-9680 ; 0000-0002-7839-9627 ; 0000-0002-4071-9031 ; 0000-0002-5472-8350 ; 0000-0002-5652-7579</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523239/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523239/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34671676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Taysi, Seyithan</contributor><contributor>Seyithan Taysi</contributor><creatorcontrib>Sabetian, Soudabeh</creatorcontrib><creatorcontrib>Jahromi, Bahia Namavar</creatorcontrib><creatorcontrib>Vakili, Sina</creatorcontrib><creatorcontrib>Forouhari, Sedighe</creatorcontrib><creatorcontrib>Alipour, Shohreh</creatorcontrib><title>The Effect of Oral Vitamin E on Semen Parameters and IVF Outcome: A Double-Blinded Randomized Placebo-Controlled Clinical Trial</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background. Male infertility is a main clinical problem that affects about 7% of all men worldwide. Many patients with male infertility are caused by a reduced antioxidant capacity of semen. Several antioxidant supplements, especially vitamin E, are proposed to help male infertility treatment. This project was goaled to study the effects of oral synthetic vitamin E (400 IU/day) for eight weeks on betterment of semen parameters and pregnancy rate. Methods. After dropping the cases, 124 infertile couples with a male factor who were admitted to the IVF program were included. The male patients with idiopathic abnormal motility and/or morphology were randomized into two groups: 61 receiving vitamin E and 63 as the control group receiving placebo for eight weeks. The pretreatment semen parameters of both groups were compared with those of posttreatment. The pregnancy outcomes were considered between the two groups. Results. There were no significant differences statistically between before and after treatment in the term of sperm volume, count, motility, and morphology. Furthermore, the IVF outcomes of the two groups were not different significantly, either. Interestingly, the percent of normal sperm in the placebo group was significantly decreased after eight weeks. Conclusion. Vitamin E supplementation might neutralize free radical activity to keep sperm from more oxidative damages. Further studies regarding the influence of higher acceptable doses of vitamin E on semen characteristics and fertility rates are needed. This study was registered as a two-arm, blinded, randomized, placebo-controlled clinical trial (IRCTID: IRCT2014020616506N1, 2014-03-18).</description><subject>Abortion</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>Age</subject><subject>Analysis</subject><subject>Antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>Birth Rate</subject><subject>Care and treatment</subject><subject>Clinical trials</subject><subject>Dietary supplements</subject><subject>Dosage and administration</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Fertility</subject><subject>Fertilization in vitro</subject><subject>Fertilization in Vitro - methods</subject><subject>Free radicals</subject><subject>Health aspects</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Infertility</subject><subject>Infertility, Male</subject><subject>Infertility, Male - drug therapy</subject><subject>Infertility, Male - 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administration & dosage</topic><topic>Birth Rate</topic><topic>Care and treatment</topic><topic>Clinical trials</topic><topic>Dietary supplements</topic><topic>Dosage and administration</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Fertility</topic><topic>Fertilization in vitro</topic><topic>Fertilization in Vitro - methods</topic><topic>Free radicals</topic><topic>Health aspects</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Infertility</topic><topic>Infertility, Male</topic><topic>Infertility, Male - drug therapy</topic><topic>Infertility, Male - physiopathology</topic><topic>Lipid peroxidation</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Morphology</topic><topic>Motility</topic><topic>Oxidative stress</topic><topic>Parameters</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Physiological aspects</topic><topic>Placebos</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Properties</topic><topic>Reproductive technologies</topic><topic>Semen</topic><topic>Semen - drug effects</topic><topic>Semen - metabolism</topic><topic>Sperm</topic><topic>Sperm Count - methods</topic><topic>Statistical analysis</topic><topic>Testing</topic><topic>Tocopherol</topic><topic>Vitamin C</topic><topic>Vitamin E</topic><topic>Vitamin E - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabetian, Soudabeh</creatorcontrib><creatorcontrib>Jahromi, Bahia Namavar</creatorcontrib><creatorcontrib>Vakili, Sina</creatorcontrib><creatorcontrib>Forouhari, Sedighe</creatorcontrib><creatorcontrib>Alipour, Shohreh</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabetian, Soudabeh</au><au>Jahromi, Bahia Namavar</au><au>Vakili, Sina</au><au>Forouhari, Sedighe</au><au>Alipour, Shohreh</au><au>Taysi, Seyithan</au><au>Seyithan Taysi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Oral Vitamin E on Semen Parameters and IVF Outcome: A Double-Blinded Randomized Placebo-Controlled Clinical Trial</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><spage>5588275</spage><epage>6</epage><pages>5588275-6</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background. Male infertility is a main clinical problem that affects about 7% of all men worldwide. Many patients with male infertility are caused by a reduced antioxidant capacity of semen. Several antioxidant supplements, especially vitamin E, are proposed to help male infertility treatment. This project was goaled to study the effects of oral synthetic vitamin E (400 IU/day) for eight weeks on betterment of semen parameters and pregnancy rate. Methods. After dropping the cases, 124 infertile couples with a male factor who were admitted to the IVF program were included. The male patients with idiopathic abnormal motility and/or morphology were randomized into two groups: 61 receiving vitamin E and 63 as the control group receiving placebo for eight weeks. The pretreatment semen parameters of both groups were compared with those of posttreatment. The pregnancy outcomes were considered between the two groups. Results. There were no significant differences statistically between before and after treatment in the term of sperm volume, count, motility, and morphology. Furthermore, the IVF outcomes of the two groups were not different significantly, either. Interestingly, the percent of normal sperm in the placebo group was significantly decreased after eight weeks. Conclusion. Vitamin E supplementation might neutralize free radical activity to keep sperm from more oxidative damages. Further studies regarding the influence of higher acceptable doses of vitamin E on semen characteristics and fertility rates are needed. This study was registered as a two-arm, blinded, randomized, placebo-controlled clinical trial (IRCTID: IRCT2014020616506N1, 2014-03-18).</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>34671676</pmid><doi>10.1155/2021/5588275</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-4215-9680</orcidid><orcidid>https://orcid.org/0000-0002-7839-9627</orcidid><orcidid>https://orcid.org/0000-0002-4071-9031</orcidid><orcidid>https://orcid.org/0000-0002-5472-8350</orcidid><orcidid>https://orcid.org/0000-0002-5652-7579</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abortion Administration, Oral Adult Age Analysis Antioxidants Antioxidants - administration & dosage Birth Rate Care and treatment Clinical trials Dietary supplements Dosage and administration Double-Blind Method Female Fertility Fertilization in vitro Fertilization in Vitro - methods Free radicals Health aspects Humans In vitro fertilization Infertility Infertility, Male Infertility, Male - drug therapy Infertility, Male - physiopathology Lipid peroxidation Male Medical treatment Morphology Motility Oxidative stress Parameters Patient outcomes Patients Physiological aspects Placebos Pregnancy Pregnancy Rate Properties Reproductive technologies Semen Semen - drug effects Semen - metabolism Sperm Sperm Count - methods Statistical analysis Testing Tocopherol Vitamin C Vitamin E Vitamin E - administration & dosage |
| title | The Effect of Oral Vitamin E on Semen Parameters and IVF Outcome: A Double-Blinded Randomized Placebo-Controlled Clinical Trial |
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