SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export block

The transcriptional induction of interferon ( IFN ) genes is a key feature of the mammalian antiviral response that limits viral replication and dissemination. A hallmark of severe COVID-19 disease caused by SARS-CoV-2 is the low presence of IFN proteins in patient serum despite elevated levels of I...

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Veröffentlicht in:	RNA (Cambridge) 2021-11, Vol.27 (11), p.1318-1329
Hauptverfasser:	Burke, James M., St Clair, Laura A., Perera, Rushika, Parker, Roy
Format:	Artikel
Sprache:	eng
Schlagworte:	COVID-19 Cytoplasm Immune response Infections Interferon Interferon regulatory factor Interferon regulatory factor 3 Localization mRNA turnover NSP1 protein Post-transcription Replication Ribonuclease L Severe acute respiratory syndrome coronavirus 2
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